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Author: Elisa López-Dolado Publisher: Springer Nature ISBN: 3030814009 Category : Medical Languages : en Pages : 327
Book Description
This book describes past and present advances in engineering materials for neural applications, with special emphasis on their usefulness for traumatic brain and spinal cord injuries. The book presents major physio-pathological features of traumatic injuries at the brain and spinal cord as examples of diseases hampering the central nervous tissue. By incorporating knowledge from the perspective of experts with diverse backgrounds, this book gives insight into the understanding of these multifaceted pathologies and the materials science approaches that aim to cure them. The interdisciplinary nature of this book makes it a perfect candidate for the interest of a broad audience, from clinicians working on neural diseases to scientists whose work focuses on the nervous tissue (neuroscientists) and/or materials science. Undergraduate and PhD students can also benefit from the knowledge and discussion included in this book.
Author: Elisa López-Dolado Publisher: Springer Nature ISBN: 3030814009 Category : Medical Languages : en Pages : 327
Book Description
This book describes past and present advances in engineering materials for neural applications, with special emphasis on their usefulness for traumatic brain and spinal cord injuries. The book presents major physio-pathological features of traumatic injuries at the brain and spinal cord as examples of diseases hampering the central nervous tissue. By incorporating knowledge from the perspective of experts with diverse backgrounds, this book gives insight into the understanding of these multifaceted pathologies and the materials science approaches that aim to cure them. The interdisciplinary nature of this book makes it a perfect candidate for the interest of a broad audience, from clinicians working on neural diseases to scientists whose work focuses on the nervous tissue (neuroscientists) and/or materials science. Undergraduate and PhD students can also benefit from the knowledge and discussion included in this book.
Author: Elizabeth Nance Publisher: Springer Nature ISBN: 3031114094 Category : Medical Languages : en Pages : 354
Book Description
This contributed volume explores the ways in which researchers engineer new biomaterials for the challenging problems of the peripheral and central nervous systems. These biomaterials are uniquely positioned for use in creating in vitro models of injury and disease, testing therapeutic treatments, understanding neural development, and mapping the multi-scalar environment of the brain. This book informs readers from biology, chemistry, materials science, engineering, and neuroscience on cutting edge research in engineering technologies, from fundamental material development through pre-clinical studies. The book also highlights target applications in three areas of research: (1) engineering neural models and materials, (2) probing biological underpinnings of neurological function and disease, and (3) designing therapeutic and diagnostic treatments for neurological disease.
Author: Lijie Grace Zhang Publisher: Springer ISBN: 3319314335 Category : Technology & Engineering Languages : en Pages : 311
Book Description
This book covers the principles of advanced 3D fabrication techniques, stem cells and biomaterials for neural engineering. Renowned contributors cover topics such as neural tissue regeneration, peripheral and central nervous system repair, brain-machine interfaces and in vitro nervous system modeling. Within these areas, focus remains on exciting and emerging technologies such as highly developed neuroprostheses and the communication channels between the brain and prostheses, enabling technologies that are beneficial for development of therapeutic interventions, advanced fabrication techniques such as 3D bioprinting, photolithography, microfluidics, and subtractive fabrication, and the engineering of implantable neural grafts.There is a strong focus on stem cells and 3D bioprinting technologies throughout the book, including working with embryonic, fetal, neonatal, and adult stem cells and a variety of sophisticated 3D bioprinting methods for neural engineering applications. There is also a strong focus on biomaterials, including various conductive biomaterials and biomimetic nanomaterials such as carbon-based nanomaterials and engineered 3D nanofibrous scaffolds for neural tissue regeneration. Finally, two chapters on in vitro nervous system models are also included, which cover this topic in the context of studying physiology and pathology of the human nervous system, and for use in drug discovery research. This is an essential book for biomedical engineers, neuroscientists, neurophysiologists, and industry professionals.
Author: Oguzhan Gunduz Publisher: Elsevier ISBN: 0323906745 Category : Medical Languages : en Pages : 482
Book Description
Biomaterials for Neural Tissue Engineering covers a range of materials and technologies used for regenerating or repairing neural tissue. With a strong focus on biomaterials and scaffolds, the book examines the testing and evaluation pathway for in-vitro and in-vivo testing trials. This book introduces the reader to the fundamentals of the nervous system from a tissue engineering perspective and goes on to describe contemporary technologies used in the development of neural repair materials, as well as currently available biomaterials suitable for neural tissue repair and regeneration. This detailed reference is ideal for those who are new to using biomaterials in tissue engineering, particularly those interested in the nervous system, including academics and early career researchers in the fields of materials science, regenerative medicine, biomedical engineering and clinical sciences. Provides readers entering the field with a core introduction to neural tissue engineering processes and real-world applications Comprehensively examines a variety of biomaterial approaches Discusses the most current in-vitro and in-vivo testing and their importance in treating nervous system disorders Details a broad range of natural and synthetic biomaterials used to engineer neural tissue
Author: Stephanie Willerth Publisher: Academic Press ISBN: 0128113863 Category : Technology & Engineering Languages : en Pages : 226
Book Description
Engineering Neural Tissue from Stem Cells covers the basic knowledge needed to understand the nervous system and how existing cells can be used to create neural tissue. This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells. It begins with the anatomy and function of the central and peripheral nervous system, also covering stem cells, their relation to the nervous system and their function in recovery after injury or disease. In addition, the book explores the role of the extracellular matrix and vasculature/immune system and biomaterials, including their suitability for neural tissue engineering applications. Provides readers entering the field with a strong basis of neural tissue engineering processes and real-world applications Discusses the most current clinical trials and their importance of treating nervous system disorders Reviews the structure and immune response of the nervous system, including the brain, spinal cord and their present cells Offers a necessary overview of the natural and synthetic biomaterials used to engineer neural tissue
Author: Jason A. Burdick Publisher: Springer Science & Business Media ISBN: 3709103851 Category : Technology & Engineering Languages : en Pages : 562
Book Description
A concise overview of tissue engineering technologies and materials towards specific applications, both past and potential growth areas in this unique discipline is provided to the reader. The specific area of the biomaterial component used within the paradigm of tissue engineering is examined in detail. This is the first work to specifically covers topics of interest with regards to the biomaterial component. The book is divided into 2 sections: (i) general materials technology (e.g., fibrous tissue scaffolds) and (ii) applications in the engineering of specific tissues (e.g., materials for cartilage tissue engineering). Each chapter covers the fundamentals and reflects not only a review of the literature, but also addresses the future of the topic. The book is intended for an audience of researchers in both industry and academia that are interested in a concise overview regarding the biomaterials component of tissue engineering, a topic that is timely and only growing as a field.
Author: A. Wilkinson Publisher: Springer Nature ISBN: 3031025822 Category : Science Languages : en Pages : 112
Book Description
Combating neural degeneration from injury or disease is extremely difficult in the brain and spinal cord, i.e. central nervous system (CNS). Unlike the peripheral nerves, CNS neurons are bombarded by physical and chemical restrictions that prevent proper healing and restoration of function. The CNS is vital to bodily function, and loss of any part of it can severely and permanently alter a person's quality of life. Tissue engineering could offer much needed solutions to regenerate or replace damaged CNS tissue. This review will discuss current CNS tissue engineering approaches integrating scaffolds, cells and stimulation techniques. Hydrogels are commonly used CNS tissue engineering scaffolds to stimulate and enhance regeneration, but fiber meshes and other porous structures show specific utility depending on application. CNS relevant cell sources have focused on implantation of exogenous cells or stimulation of endogenous populations. Somatic cells of the CNS are rarely utilized for tissue engineering; however, glial cells of the peripheral nervous system (PNS) may be used to myelinate and protect spinal cord damage. Pluripotent and multipotent stem cells offer alternative cell sources due to continuing advancements in identification and differentiation of these cells. Finally, physical, chemical, and electrical guidance cues are extremely important to neural cells, serving important roles in development and adulthood. These guidance cues are being integrated into tissue engineering approaches. Of particular interest is the inclusion of cues to guide stem cells to differentiate into CNS cell types, as well to guide neuron targeting. This review should provide the reader with a broad understanding of CNS tissue engineering challenges and tactics, with the goal of fostering the future development of biologically inspired designs. Table of Contents: Introduction / Anatomy of the CNS and Progression of Neurological Damage / Biomaterials for Scaffold Preparation / Cell Sources for CNS TE / Stimulation and Guidance / Concluding Remarks
Author: Sujata K. Bhatia Publisher: Springer Science & Business Media ISBN: 1461410800 Category : Technology & Engineering Languages : en Pages : 350
Book Description
Regeneration of tissues and organs remains one of the great challenges of clinical medicine, and physicians are constantly seeking better methods for tissue repair and replacement. Tissue engineering and regenerative medicine have been investigated for virtually every organ system in the human body, and progress is made possible by advances in materials science, polymer chemistry, and molecular biology. This book reviews the current status of biomaterials for regenerative medicine, and highlights advances in both basic science and clinical practice. The latest methods for regulating the biological and chemical composition of biomaterials are described, together with techniques for modulating mechanical properties of engineered constructs. Contributors delineate methods for guiding the host response to implantable materials, and explain the use of biologically-inspired materials for optimal biological functionality and compatibility. The book culminates in a discussion of the clinical applications of regenerative medicine. By integrating engineering and clinical medicine, Engineering Biomaterials for Regenerative Medicine examines how tissue engineering and regenerative medicine can be translated into successful therapies to bridge the gap between laboratory and clinic. The book will aid materials scientists and engineers in identifying research priorities to fulfill clinical needs, and will also enable physicians to understand novel biomaterials that are emerging in the clinic. This integrated approach also gives engineering students a sense of the excitement and relevance of materials science in the development of novel therapeutic strategies.
Author: A. E. Wilkinson Publisher: Morgan & Claypool Publishers ISBN: 1608457877 Category : Technology & Engineering Languages : en Pages : 122
Book Description
Combating neural degeneration from injury or disease is extremely difficult in the brain and spinal cord, i.e. central nervous system (CNS). Unlike the peripheral nerves, CNS neurons are bombarded by physical and chemical restrictions that prevent proper healing and restoration of function. The CNS is vital to bodily function, and loss of any part of it can severely and permanently alter a person's quality of life. Tissue engineering could offer much needed solutions to regenerate or replace damaged CNS tissue. This review will discuss current CNS tissue engineering approaches integrating scaffolds, cells and stimulation techniques. Hydrogels are commonly used CNS tissue engineering scaffolds to stimulate and enhance regeneration, but fiber meshes and other porous structures show specific utility depending on application. CNS relevant cell sources have focused on implantation of exogenous cells or stimulation of endogenous populations. Somatic cells of the CNS are rarely utilized for tissue engineering; however, glial cells of the peripheral nervous system (PNS) may be used to myelinate and protect spinal cord damage. Pluripotent and multipotent stem cells offer alternative cell sources due to continuing advancements in identification and differentiation of these cells. Finally, physical, chemical, and electrical guidance cues are extremely important to neural cells, serving important roles in development and adulthood. These guidance cues are being integrated into tissue engineering approaches. Of particular interest is the inclusion of cues to guide stem cells to differentiate into CNS cell types, as well to guide neuron targeting. This review should provide the reader with a broad understanding of CNS tissue engineering challenges and tactics, with the goal of fostering the future development of biologically inspired designs. Table of Contents: Introduction / Anatomy of the CNS and Progression of Neurological Damage / Biomaterials for Scaffold Preparation / Cell Sources for CNS TE / Stimulation and Guidance / Concluding Remarks
Author: Lynne E. Bilston Publisher: Springer Science & Business Media ISBN: 364213890X Category : Technology & Engineering Languages : en Pages : 288
Book Description
Damage to the central nervous system resulting from pathological mechanical loading can occur as a result of trauma or disease. Such injuries lead to significant disability and mortality. The peripheral nervous system, while also subject to injury from trauma and disease, also transduces physiological loading to give rise to sensation, and mechanotransduction is also thought to play a role in neural development and growth. This book gives a complete and quantitative description of the fundamental mechanical properties of neural tissues, and their responses to both physiological and pathological loading. This book reviews the methods used to characterize the nonlinear viscoelastic properties of central and peripheral neural tissues, and the mathematical and sophisticated computational models used to describe this behaviour. Mechanisms and models of neural injury from both trauma and disease are reviewed from the molecular to macroscopic scale. The book provides a comprehensive picture of the mechanical and biological response of neural tissues to the full spectrum of mechanical loading to which they are exposed. This book provides a comprehensive reference for professionals involved in pre prevention of injury to the nervous system, whether this arises from trauma or disease.
Author: Elisa López-Dolado
Author: Elisa López-Dolado
Author: Elizabeth Nance
Author: Lijie Grace Zhang
Author: Oguzhan Gunduz
Author: Stephanie Willerth
Author: Jason A. Burdick
Author: A. Wilkinson
Author: Sujata K. Bhatia
Author: A. E. Wilkinson
Author: Lynne E. Bilston