Energetics of Triple Helix Formation by Oligonucleotides Containing Nonnatural Bases PDF Download

Author: Eldon Scott Priestley
Publisher:
ISBN:
Category :
Languages : en
Pages : 384

View

Book Description

Author: Claude Malvy
Publisher: Springer Science & Business Media
ISBN: 1461551773
Category : Science
Languages : en
Pages : 296

View

Book Description
Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.

Author: Stanley T. Crooke
Publisher: Springer Science & Business Media
ISBN: 3642587852
Category : Medical
Languages : en
Pages : 646

View

Book Description
Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.

Author: Ramon Eritja
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 311063953X
Category : Science
Languages : en
Pages : 380

View

Book Description
This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 6

View

Book Description
Triple Helix Design Principles. The first research priority of the program of Navy support was to refine our understanding of triple helix forming oligonucleotides (TFOs). Binding affinity and strand orientation of triplex forming oligonucleotides were measured as a function of base composition. Based upon that work, which was published in Biochemistry (ref. 3), we showed that triple helices containing GGC and TAT triplets were stable at physiological pH and prefer to bind with an antiparallel strand orientation. This study and the accompanying patent application provided the first evidence that TFOs can bind in a site selective fashion at physiological pH and the first explicit evidence for a new (antiparallel) class of triple helix. This work also served as the basis for the filing of a continuation in part to a patent application, filed 12/89. DNA Recognition, Triplet helix formation.

Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 784

View

Book Description

Author: Jurgen-Hinrich Fuhrhop
Publisher: CRC Press
ISBN: 9780824782016
Category : Science
Languages : en
Pages : 618

View

Book Description
An assessment of the known properties of natural products and their model compounds to determine their usefulness in biological and medical experimentation, as well as in synkinetics - the reversible synthesis of noncovalent compounds. It explores new techniques such as cryoelectron and scanning force microscopy and solid-state NMR spectroscopy of membrane systems. There are 500 figures and reaction schemes.

Author:
Publisher:
ISBN:
Category : Nucleic acids
Languages : en
Pages : 904

View

Book Description

Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1876

View

Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Author:
Publisher:
ISBN:
Category : Dissertation abstracts
Languages : en
Pages : 896

View

Book Description