Endotheliopathies: Current concepts and Importance in Clinical Practice PDF Download

Author: Eleni Gavriilaki
Publisher: Frontiers Media SA
ISBN: 2832519458
Category : Medical
Languages : en
Pages : 126

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Book Description

Author: A. Hargens
Publisher: Alpha Science Int'l Ltd.
ISBN: 9788173195716
Category : Medical
Languages : en
Pages : 366

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Book Description
Recognition of adaptive processes in biological systems as a discipline is still in its infancy. It is known that repeat exposure to low level stresses such as heat, cold, microgravity, hypoxia, exercise, etc. increases body-resistance to not only the particular stress but also to other conditions. Such a cross-protection can be utilized in a better patient care. This volume describes most current developments in the understanding of the molecular basis of adaptation as well as its application in biological systems including certain disease conditions in humans. The book is based on the presentations made by internationally known experts assembled in San Diego, USA for the 7th World Congress of the International Society for Adaptive Medicine and will be of great interest to experimental biologists as well as clinicians who deal with a wide variety of clinical conditions.

Author: Israel Vlodavsky
Publisher: Springer Nature
ISBN: 3030345211
Category : Medical
Languages : en
Pages : 871

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Book Description
Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Author: Hunter B. Moore
Publisher: Springer Nature
ISBN: 3030536068
Category : Medical
Languages : en
Pages : 802

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Book Description
The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.

Author: Mark F. Newman
Publisher: Elsevier Health Sciences
ISBN: 0323567207
Category : Medical
Languages : en
Pages : 723

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Book Description
Based on the most current evidence and best practices, Perioperative Medicine: Managing for Outcome, 2nd Edition, is an easy-to-follow, authoritative guide to achieving optimal outcomes in perioperative care. Written and edited by recognized authorities in anesthesiology and surgical critical care, this fully updated edition helps you think critically about complex, long-term issues surrounding the care of the surgical patient, providing decision trees that define strategies to enhance the medical outcome of care. - Focuses on what anesthesiologists, surgeons, and intensivists need to know in order to improve outcomes through evidence- and outcome-based approaches. - Provides practical guidance on potential risks to all major organ systems, the etiology of particular organ dysfunctions, preoperative and intraoperative risk factors, and perioperative protection strategies to minimize potential complications. - Features a consistent chapter format - with even more color-coded algorithms, summary tables, and boxes – that enables you to quickly explore and determine the best management approaches. - Includes six all-new chapters: Perioperative Fluid Management; Delirium and POCD; Role of Palliative Care/ICU; Value-Based Care: The UK Model; CFO Perspective on Value; Hospital to Home (Perioperative Transitions of Care) - Discusses timely topics such as quality improvement, pay-for-performance, preexisting disease and comorbid conditions in anesthesiology, and the team-based model of care. - Features two new editors, surgeon Clifford Ko, MD, and Perioperative Summit leader, Michael (Monty) Mythen, MD.

Author: Michael Brainin
Publisher: Cambridge University Press
ISBN: 1107047498
Category : Medical
Languages : en
Pages : 425

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Book Description
Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.

Author: Louis R. Caplan
Publisher: Academic Press
ISBN: 0080539513
Category : Science
Languages : en
Pages : 855

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Book Description
Primer on Cerebrovascular Diseases is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, and presents the information in a comprehensive and easily accessible manner. The book also contains valuable information on practical applications of basic research. - Presents topics in a comprehensive and accessible format - Written by international authorities on cerebral vasculature - Provides practical applications for researchers

Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1248

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Book Description

Author: Sudha Seshadri
Publisher: Oxford University Press
ISBN: 0199337055
Category : Medical
Languages : en
Pages : 489

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Book Description
Risk Factors for Cerebrovascular Disease and Stroke address the relationship of a wide variety of vascular risk factors in the spectrum of cerebrovascular diseases. An international group of professionals the forefront of research and education, provide their expertise about environmental and genetic determinants for cerebrovascular disease and stroke. The authors aim to provide information on developments of genetic, environmental and lifestyle-related risk factors of various subtypes of stroke, and MRI-markers of cerebrovascular disease. One in two men, and one in three women after the age of 40, will develop a stroke in their lifetime. The burden of cerebrovascular disease extends far beyond that of acute clinical events such as stroke, with "covert" vascular injury on brain MRI being highly prevalent in older community-dwelling persons. Therefore, improving our understanding of the risk factors for stroke and cerebrovascular disease is of paramount importance for improving prevention strategies. Secular trends in stroke epidemiology, risk factors, and intermediate markers (including carotid ultrasound, brain MRI and circulating biomarkers) are presented. Cutting edge information on genetic, environmental and lifestyle-related risk factors of various subtypes of stroke and MRI-markers of cerebrovascular diseases are displayed. This important book is an essential reference to physicians interested in more effective primary prevention of stroke.

Author: Robert G. Hahn
Publisher: Cambridge University Press
ISBN: 1107119553
Category : Medical
Languages : en
Pages : 309

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Book Description
The world's most renowned researchers in fluid management explain what you should know when providing infusion fluids to surgical patients.