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Author: Vladimir Kuklin Publisher: LAP Lambert Academic Publishing ISBN: 9783659317187 Category : Languages : en Pages : 104
Book Description
Acute lung injury (ALI) is a common complication of different conditions like sepsis, shock and trauma, which may emerge into full-blown acute respiratory distress syndrome (ARDS). During the last 15 years, participation of the endothelin-1 (ET-1) system in the pathogenesis of ALI/ARDS has been intensively studied. In sepsis-induced acute lung injury (ALI), endothelin-1 (ET-1) is suspected of increasing lung capillary pressure and probably permeability. In present study, we studied pulmonary hemodynamic, volumetric and permeability effects of the non-selective ET-1 receptor antagonist, tezosentan, in animals with endotoxin or sepsis-induced ALI. We also studied the activation of protein kinase C alpha and expression of mRNA for prepro-ET-1 and its receptors in animals lung tissue cells. Additionally, we investigated the relationship between the plasma concentration of ET-1 and extravascular lung water index (EVLWI) in septicemic patients.
Author: Vladimir Kuklin Publisher: LAP Lambert Academic Publishing ISBN: 9783659317187 Category : Languages : en Pages : 104
Book Description
Acute lung injury (ALI) is a common complication of different conditions like sepsis, shock and trauma, which may emerge into full-blown acute respiratory distress syndrome (ARDS). During the last 15 years, participation of the endothelin-1 (ET-1) system in the pathogenesis of ALI/ARDS has been intensively studied. In sepsis-induced acute lung injury (ALI), endothelin-1 (ET-1) is suspected of increasing lung capillary pressure and probably permeability. In present study, we studied pulmonary hemodynamic, volumetric and permeability effects of the non-selective ET-1 receptor antagonist, tezosentan, in animals with endotoxin or sepsis-induced ALI. We also studied the activation of protein kinase C alpha and expression of mRNA for prepro-ET-1 and its receptors in animals lung tissue cells. Additionally, we investigated the relationship between the plasma concentration of ET-1 and extravascular lung water index (EVLWI) in septicemic patients.
Author: Kenneth Brigham Publisher: CRC Press ISBN: 9781439805510 Category : Medical Languages : en Pages : 582
Book Description
This work sets out to provide the information necessary for understanding endotoxin and its effects on the lungs, and explicates the difficulties in determining how to manipulate endotoxin pathobiology. The rationale for, and efficacy of, current and experimental treatments for sepsis, adult respiratory distress syndrome and other endotoxin-induced lung injuries are discussed.
Author: J.J. Marini Publisher: Springer Science & Business Media ISBN: 3642607330 Category : Medical Languages : en Pages : 466
Book Description
To integrate current knowledge in terms of basic and clinical science and to highlight problems, thirty world-renowned experts in the field of acute lung injury describe the state of up to date knowledge regarding the epidemiology, pathophysiology, and clinical management of acute lung injury. Novel techniques for the clinical support of these difficult patients are discussed in full. Prospects for successful pharmacological intervention are also outlined. This book is aimed at those practising within the field of critical care and is likely to become an indispensable aid to all concerned with the investigation and management of patients with severe respiratory failure.
Author: Robert R. Ruffolo, Jr. Publisher: CRC Press ISBN: 9780849359385 Category : Science Languages : en Pages : 302
Book Description
Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans. This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.
Author: Hector R. Wong Publisher: Springer Science & Business Media ISBN: 9780792374343 Category : Medical Languages : en Pages : 348
Book Description
Acute lung injury (ALI) impacts patient care in every ICU in the world. Our collective understanding of this condition has grown immensely over the past decade but morbidity and mortality remain unacceptably high. To enhance the understanding of clinicians and researchers, this book addresses the pathophysiology of acute lung injury from a molecular and cellular standpoint; includes animal models of acute lung injury and points to potential therapeutic advances based on scientific findings. It is a concise compendium of the multiple pathways, mechanisms and molecules involved in the pathophysiology of acute lung injury and is intended to help caregivers understand the process and thus care for patients more effectively.
Author: C.E. Patterson Publisher: Elsevier ISBN: 0444518347 Category : Medical Languages : en Pages : 540
Book Description
Covers endothelial biology from the fundamentals of structure and lung fluid balance physiology to descriptions of the molecular mechanisms involved in the development of lung failure. This illustrated text provides the knowledge of endothelial function, vascular integrity, pulmonary function, and pathophysiology in respiratory failure.
Author: Timothy W. Evans Publisher: Springer ISBN: 1489934308 Category : Medical Languages : en Pages : 537
Book Description
Great progress has been made since the first description of the acute respiratory distress syndrome by the Denver group in 1967 (Lancet). Although we introduced the term 'adult respiratory distress syndrome' in our second and more detailed description of the syndrome (ehest, 1971), this was probably amistake for the simple reason that children also suffer the same syndrome fo11owing acute lung insults. Today, the syndrome of acute respiratory distress in adults (ARDS) is recognized as a worldwide problem, but the prevalence of disease varies in different parts of the world. A huge amount of research has focused on the mechanisms of acute lung injury and yet the exact sequence of events and media tors in inflammatory cascade, which result in acute respiratory failure from ARDS, is not known but many possibilities exist. The definition of ARDS has been gradua11y modified in recent years and investigators around the world are now co11aborating in order to establish more uniform concepts in identification, risk factors and mechanisms of lung injury, which someday will result in improved approaches to management. Already, at least some centers are showing improved outcomes in ARDS, achieving an approximate 60% survival rate. In the past, most large series documented only about a 40% survivability taking a11 causes of ARDS. This apparent progress is likely attributable to more meticulous and disciplined care than any specific pharmacologic attack on the basic mechanism resulting in ARDS.
Author: Wolfgang Krüger Publisher: Springer ISBN: 3642549713 Category : Medical Languages : en Pages : 428
Book Description
This book provides a detailed review of state of the art knowledge on critical care topics as well as the latest research findings. It covers the core aspects in excellent detail, but is not so comprehensive as to make its daily use unfeasible. For each condition considered, discussion of the pathophysiology is integrated with observations on diagnosis and treatment in order to allow a deeper understanding. The book is scientifically based, with extensive references to published research. This will allow readers to investigate their individual interests further and will enable physicians to justify measures by providing a coherent, evidence-based strategy and relevant citations where needed. Core Knowledge in Critical Care Medicine will appeal to experienced practitioners as an aide-mémoire, but will also be of great value to a wide range of more junior staff wishing to complement their background knowledge with important facts applicable to everyday practice.
Author: Vladimir Kuklin
Author: Vladimir Kuklin
Author: Kenneth Brigham
Author: J.J. Marini
Author: 
Author: Robert R. Ruffolo, Jr.
Author: Hector R. Wong
Author: C.E. Patterson
Author: Timothy W. Evans
Author: 
Author: Wolfgang Krüger