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Author: E. Leong Way Publisher: Elsevier ISBN: 1483145263 Category : Medical Languages : en Pages : 593
Book Description
Endogenous and Exogenous Opiate Agonists and Antagonists documents the proceedings of the International Narcotic Research Club Conference, held in North Falmouth, Massachusetts, USA, on 11-15 June 1979. The volume begins with a discussion of the programs of the World Health Organization, with an emphasis on the components of its drug dependence program. The 139 papers discussed at the conference are then presented. These papers are organized into 10 parts. The papers in Part I examine structure-activity relationships. Part II contains studies on receptor binding while Part III deals with the localization and characterization of active sites. Part IV focuses on ligands and receptor isolation. Part 5 examines neurochemical interactions. Part VI presents papers on disposition and metabolism. Parts VII and VIII take up analgetic mechanisms and neuroendocrine relationships, respectively. Part IX focuses on behavioral effects while the studies in Part X cover tolerance and physical dependence.
Author: E. Leong Way Publisher: Elsevier ISBN: 1483145263 Category : Medical Languages : en Pages : 593
Book Description
Endogenous and Exogenous Opiate Agonists and Antagonists documents the proceedings of the International Narcotic Research Club Conference, held in North Falmouth, Massachusetts, USA, on 11-15 June 1979. The volume begins with a discussion of the programs of the World Health Organization, with an emphasis on the components of its drug dependence program. The 139 papers discussed at the conference are then presented. These papers are organized into 10 parts. The papers in Part I examine structure-activity relationships. Part II contains studies on receptor binding while Part III deals with the localization and characterization of active sites. Part IV focuses on ligands and receptor isolation. Part 5 examines neurochemical interactions. Part VI presents papers on disposition and metabolism. Parts VII and VIII take up analgetic mechanisms and neuroendocrine relationships, respectively. Part IX focuses on behavioral effects while the studies in Part X cover tolerance and physical dependence.
Author: Hiroshi Takagi Publisher: Elsevier ISBN: 1483161595 Category : Medical Languages : en Pages : 520
Book Description
Advances in Endogenous and Exogenous Opioids contains the proceedings of the International Narcotic Research Conference (Satellite Symposium of the 8th International Congress of Pharmacology) held in Kyoto, Japan on July 26-30, 1981. The conference provided a forum for discussing advances that have been made in the understanding of endogenous and exogenous opioids and tackled a wide array of topics ranging from novel opiate binding sites selective for benzomorphan drugs to the purification of opioid receptors and sequellae of receptor binding. Comprised of 156 chapters, this book begins with an analysis of the interaction of opioid peptides and alkaloid opiates with mu-, delta-, and kappa-binding sites. The reader is then systematically introduced to biochemical evidence for kappa and sigma opiate receptors; the action of morphine and oxymorphone as partial agonists on the field-stimulated rat vas deferens; mechanisms of supersensitivity in the enkephalinergic system; and properties of the solubilized opiate receptor from human placenta. Subsequent chapters explore the biosynthesis of opioid peptides as well as their localization, release, and degradation; physiological and pharmacological actions of opioids; and the use of analgesia in acupuncture. Results of behavioral and clinical studies of endogenous and exogenous opioids are also presented, and the structure-activity relationships of opioids are examined. This monograph will be of interest to students, practitioners, and researchers in the fields of psychiatry and pharmacology.
Author: Reginald Dean Publisher: Springer Science & Business Media ISBN: 1597451975 Category : Medical Languages : en Pages : 767
Book Description
Comprehensive and authoritative, Opioid Receptors and Antagonists: From Bench to Clinic offers neuroscientists, pharmacologists and interested clinicians a unique survey of the extensive and diverse research efforts currently employed with opioid antagonists to develop novel innovative drug therapies. Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes Highlights differences and similarities between the opioid pharmacology of animals and human Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications
Author: Enno Freye Publisher: ISBN: Category : Medical Languages : en Pages : 124
Book Description
The concept of this manuscript is to incorporate the basic knowledge which is necessary for the practical use of central analgesics and their antagonists in a concise and understandable form. With this concept in mind the enormous advances of the last decade with regard to the mode of action of opioids are covered. The manuscript is not intended to be a scientific textbook; rather, it is meant to be an introductory reference book about opioids and their antagonists, and about their pros and cons with regard to the various specialities where opioids are used for the alleviation of pain. Because of its brevity there is no question of its being complete. Where new information necessitates extended explanation, there is a detailed discussion. In other cases value has been placed on conciseness. The author is grateful for any advice, corrections and suggestions. The work of William A. Coleman, who prepared the translation, is greatly appre ciated. Dusseldorf, January 1987 EnnoFreye Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V The Use of Opioids During Anaesthesia and Their Importance in Clinical Application ................................... 1 Classical Potentiated Anaesthesia ............................ 3 Relaxation Anaesthesia .................................. 3 Neurolepsis .......................................... 4 Neuroleptanaesthesia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Sequential Anaesthesia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Synaptangalgesia ...................................... 8 Balanced Anaesthesia ................................... 9 Techniquefor Balanced Anaesthesia Using Narcotic Analgesics ......... 10 The Mode of Action of Opioids . . . . . . . . . . . . . . . . . . . . . . . 15 . . . . . . . Specific Binding Sites for Opioids in the CNS ..................... 15 The Three Main Characteristics of Pain . . . . . . . . . . . . . . . . . .. . . . 19 . . .
Author: Catherine F. Stannard Publisher: Oxford University Press ISBN: 0199678073 Category : Medical Languages : en Pages : 121
Book Description
This pocketbook summarizes the recent developments in this important and controversial aspect of pain management, looking at the benefits and adverse effects of opioids in non-cancer pain.
Author: Colin Pinnock Publisher: Cambridge University Press ISBN: 9780521690799 Category : Medical Languages : en Pages : 990
Book Description
The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.
Author: Howard L. Fields Publisher: Elsevier Publishing Company ISBN: 9780444809841 Category : Medical Languages : en Pages : 454
Book Description
This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.
Author: Gavril Pasternak Publisher: Springer Science & Business Media ISBN: 1607619903 Category : Medical Languages : en Pages : 502
Book Description
The growth of the opiate field over the past decade has been enor mous. Initial interest focused upon the strategic clinical impor tance of morphine and its analogs, but the discovery of the enkephalins and the other endogenous opioid peptides with their widespread actions within brain has expanded the field to investi gators in almost all areas of neuroscience as well as pharmacol ogy. Unfortunately, this field of research with its vast literature has become progressively more complex. The receptors are no longer limited to opiates, but include many subtypes selective for the opioid peptides. Indeed, they might be better termed opioid, rather than opiate, receptors. Many controversies have emerged and been settled; others remain. Early studies must now be inter preted on the basis of current information. Thousands of papers examining various aspects of opiates and the endogenous opioids present separate pieces of a large puzzle. The goal of this volume is to put the pieces together to give a coherent overview of opiate receptor pharmacology and to provide insights into both the mo lecular and classical pharmacology of opiates and the opioid pep tides. The issue of multiple classes of opiate and opioid peptide re ceptors and their importance in understanding mechanisms of ac tion provides the major focus of the book. The study of opiates and opioid peptides provides a unique research opportunity in the neuropharmacology of drug receptors.
Author: E. Leong Way
Author: E. Leong Way
Author: E. Leong Way
Author: Hiroshi Takagi
Author: Reginald Dean
Author: Enno Freye
Author: Catherine F. Stannard
Author: Colin Pinnock
Author: József Iván Székely
Author: Howard L. Fields
Author: Gavril Pasternak