Author: Michael George PollackPublisher:
ISBN:
Category : Microelectromechanical systems
Languages : en
Pages : 306
Book Description
Electrowetting-based Microactuation of Droplets for Digital Microfluidics
Author: Michael George PollackPublisher:
ISBN:
Category : Microelectromechanical systems
Languages : en
Pages : 306
Book Description
Microfluidics Based Microsystems
Author: S. KakaçPublisher: Springer Science & Business Media
ISBN: 9048190312
Category : Science
Languages : en
Pages : 622
Book Description
This volume contains an archival record of the NATO Advanced Study Institute on Microfluidics Based Microsystems – Fundamentals and App- cations held in Çe ?me-Izmir, Turkey, August 23–September 4, 2009. ASIs are intended to be high-level teaching activity in scientific and technical areas of current concern. In this volume, the reader may find interesting chapters and various microsystems fundamentals and applications. As the world becomes increasingly concerned with terrorism, early - spot detection of terrorist’s weapons, particularly bio-weapons agents such as bacteria and viruses are extremely important. NATO Public Diplomacy division, Science for Peace and Security section support research, Advanced Study Institutes and workshops related to security. Keeping this policy of NATO in mind, we made such a proposal on Microsystems for security. We are very happy that leading experts agreed to come and lecture in this important NATO ASI. We will see many examples that will show us Microfluidics usefulness for rapid diagnostics following a bioterrorism attack. For the applications in national security and anti-terrorism, microfluidic system technology must meet the challenges. To develop microsystems for security and to provide a comprehensive state-of-the-art assessment of the existing research and applications by treating the subject in considerable depth through lectures from eminent professionals in the field, through discussions and panel sessions are very beneficial for young scientists in the field.
Micro-Drops and Digital Microfluidics
Author: Jean BerthierPublisher: William Andrew
ISBN: 1455728004
Category : Technology & Engineering
Languages : en
Pages : 560
Book Description
In this 2nd edition of Micro-Drops and Digital Microfluidics, Jean Berthier explores the fundamentals and applications of digital microfluidics, enabling engineers and scientists to design this important enabling technology into devices and harness the considerable potential of digital microfluidics in testing and data collection. This book describes the most recent developments in digital microfluidics, with a specific focus on the computational, theoretical and experimental study of microdrops. Unique in its emphasis on digital microfluidics and with diverse applications ranging from drug delivery to point-of-care diagnostic chips, organic synthesis to microreactors, Micro-Drops and Digital Microfluidics meets the needs of audiences across the fields of bioengineering and biotechnology, and electrical and chemical engineering. Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops." A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow) A fresh perspective on the future of microfluidics
Droplet Actuation on Various Electrode Shapes in Electrowetting-based Microfluidics
Author: Negar RajabiPublisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Electrowetting has been widely used in digital microfluidics as a reliable actuation method due to its considerable advantages such as the absence of heat generation, rapid switching response, flexibility, and low power consumption. Research on the improvement of this method has turned into one of the attractive fields in the design of fluid handling micro devices. This work presents a combined numerical and experimental study to investigate the effect of electrode shape in electrowetting-based microsystems. A new crescent-shaped electrode is proposed which provides a uniform actuation force at the contact line as well as overlap between the adjacent electrodes. The onset of actuation and droplet mobility on electrode arrays have been investigated. The numerical method is based on the Volume of Fluid technique to track the 3-D interface along with the Laplace equation solver to calculate the electric field in the domain. Furthermore, the dynamic behaviour of tri-phase contact line is modeled using the molecular-kinetic theory. Validation experiments were carried out to characterize the droplet actuation on various electrode shapes. The superior performance of the new electrode shape is demonstrated by comparing the droplet velocity and deformation, as well as contact angle distribution with those of a simple flat electrode. Using crescent electrode, the droplet actuation occurs with less deformation and higher velocities. The velocities obtained by using the crescent electrode are up to 4 times at the onset of the actuation and 2 times at the steady state motion of those on the flat electrode. The novel crescent shape can even actuate the droplets which are not placed on the electrode.
Electrowetting
Author: Frieder MugelePublisher: John Wiley & Sons
ISBN: 3527412298
Category : Science
Languages : en
Pages : 323
Book Description
Starting from the basic principles of wetting, electrowetting and fluid dynamics all the way up to those engineering aspects relevant for the development of specific devices, this is a comprehensive introduction and overview of the theoretical and practical aspects. Written by two of the most knowledgeable experts in the field, the text covers both current as well as possible future applications, providing basic working principles of lab-on-a-chip devices and such optofluidic devices as adaptive lenses and optical switches. Furthermore, novel e-paper display technology, energy harvesting and supercapacitors as well as electrowetting in the nano-world are discussed. Finally, the book contains a series of exercises and questions for use in courses on microfluidics or electrowetting. With its all-encompassing scope, this book will equally serve the growing community of students and academic and industrial researchers as both an introduction and a standard reference.
Microdroplet Technology
Author: Philip DayPublisher: Springer Science & Business Media
ISBN: 1461432650
Category : Science
Languages : en
Pages : 249
Book Description
Microdroplet technology has recently emerged to provide new and diverse applications via microfluidic functionality, especially in various areas of biology and chemistry. This book, then, gives an overview of the principle components and wide-ranging applications for state-of-the-art of droplet-based microfluidics. Chapter authors are internationally-leading researchers from chemistry, biology, physics and engineering that present various key aspects of micrdroplet technology -- fundamental flow physics, methodology and components for flow control, applications in biology and chemistry, and a discussion of future perspectives. This book acts as a reference for academics, post-graduate students, and researcher wishing to deepen their understand of microfluidics and introduce optimal design and operation of new droplet-based microfluidic devices for more comprehensive analyte assessments.
Droplet and Digital Microfluidics
Author: Sanket GoelPublisher: Elsevier
ISBN: 0443154171
Category : Technology & Engineering
Languages : en
Pages : 276
Book Description
Droplet and Digital Microfluidics: Ideation to Implementation is a detailed introduction to the dynamics of droplet and digital microfluidics, also featuring coverage of new methods and applications. The explosion of applications of microelectromechanical systems (MEMS) in recent years has driven demand for expertise and innovation in fluid flow in the microchannels they contain. In this book, detailed descriptions of methods for biological and chemical applications of microfluidics are provided, along with supporting foundational knowledge. In addition, the principles of droplet and digital microfluidics are explained, along with their different applications and governing physics. New additions to the technological knowledgebase that enable advances in droplet and digital microfluidics include machine learning and exciting future avenues for research. Provides step-by-step fabrication, testing, and characterization instructions in each chapter to support implementation Includes explanations of applications and methods in biological and chemical settings Describes the path to automation of digital and droplet microfluidic platforms
Finger-powered Digital Microfluidics for Micro Droplet Manipulation
Author: Cheng PengPublisher:
ISBN:
Category :
Languages : en
Pages : 201
Book Description
Microfluidic devices that do not require bulky peripheral hardware, such as pumps and external battery/power supplies, are a suitable technology for portable applications in resource-constrained settings, such as point-of-care (POC) diagnosis in developed countries, environmental monitoring, and on-site forensic analysis, etc. The existing portable microfluidic devices are mostly based on microchannel structures, in which the pre-defined channels limit their functional flexibility, rendering them difficult to scale up. Digital microfluidics, on the other hand, can tackle this problem since they deal with discrete droplets individually and can therefore provide more on-demand flexibility and versatility. Most digital microfluidic devices, however, require external electric power sources. We first propose finger-powered digital microfluidic (F-DMF) based on electrowetting on dielectric (EWOD). Instead of requiring an external power supply, our F-DMF uses piezoelectric elements to convert the mechanical energy produced by human fingers into electric voltage pulses for droplet manipulation. The voltage outputs of piezoelectric element mounted in cantilever beam configuration are studied theoretically and experimentally. Using this energy conversion scheme, the basic modes of droplet operations, such as droplet transport, splitting, and merging on EWOD devices are confirmed. The key assay steps involved in glucose detection and immunoassay are also successfully performed using F-DMF-EWOD. Exploiting the same energy conversion scheme, F-DMF based on the electrophoretic transport of discrete droplets (EPD), which has the potential to overcome pinning and surface contamination often encountered in EWOD, is then presented. Successful EPD actuation, however, requires the piezoelectric elements to provide both sufficient charge and voltage pulse duration. These requirements are quantified using numerical models to predict the electrical charges induced on the droplets and the subsequent electrophoretic forces. The transport and merging of aqueous droplets as well as direct manipulation of body fluids is experimentally demonstrated using F-EPD-DMF. Further, a mechanical system and an efficient pin-assignment scheme are explored to facilitate the practical implementation of pre-programmed and functional actuation of droplets in the EPD-based system. For the second part of this thesis, one practical issue in digital microfluidics biochip (DMFB) design is discussed: the droplet routing problem, which largely decides the performance and correctness of the system. The problem is formulated to a multi-agent path finding problem (MAPF) and an approximate algorithm based on Independent Detection (ID) is applied to solve the problem. The modified ID algorithm shows promising performance on selected benchmark problems with medium number of droplets ( 12). Overall, it achieves better timing result (~15% reduction) and total routing length (~50% reduction) with no compromise in fault tolerance (indicated by the total number of used cells), when compared with the previous best known results.
Digital Microfluidic Biochips
Author: Krishnendu ChakrabartyPublisher: CRC Press
ISBN: 1420008307
Category : Technology & Engineering
Languages : en
Pages : 228
Book Description
Digital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips. The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increase the yield and dependability of digital microfluidic biochips. Expanding upon results from ongoing research on CAD for biochips at Duke University, this book presents new design methodologies that address some of the limitations in current full-custom design techniques. Digital Microfluidic Biochips is an essential resource for achieving the integration of microfluidic components in the next generation of system-on-chip and system-in-package designs.
Author: Daniel Brassard