Electrospun and Electrosprayed Formulations for Drug Delivery PDF Download

Author: Ian S. Blagbrough
Publisher: MDPI
ISBN: 3038979120
Category : Medical
Languages : en
Pages : 1

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Book Description
This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.

Author: Cornejo Bravo José
Publisher:
ISBN:
Category : Science
Languages : en
Pages :

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Book Description
Electrospinning is a very versatile techniqueused for many purposes, such as tissue engineering, textiles, air and water treatment filter, solar cells, and drug delivery systems, among others. This method is cheap, easy to handle, reproducible when ambient parameters are controlled, and can be used for many formulations. The objective of this review is to enlist and emphasize the advantages and disadvantages of different methods for incorporating therapeutic drugs in a drug delivery system with electrospinning. The importance of the research to create new and innovative drug carriers is high, because of their efficiency of transporting the bioactive agent to the target zone, avoiding secondary effects in the body. Nanofibers and nanoparticles have become an important strategy in pharmacology due to their physicochemical and biocompatible properties useful for this purpose. Among the techniques compared are blending coaxial, emulsion and surface modification electrospinning, followed by electrospray and coaxial electrospray. The present review concludes that every technique has advantages and disadvantages and, not all drugs can be loaded with any method, the strategy used will depend on the drug's physicochemical properties, target zone, polymeric characteristics, and required drug release rate. This chapter will serve as a starting point for when to choose one of the drug incorporation techniques mentioned.

Author: Sajjad Haider
Publisher: BoD – Books on Demand
ISBN: 1789847001
Category : Science
Languages : en
Pages : 122

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Book Description
This book focuses on the recent advancements in the process parameters, research, and applications of electrospinning and electrospraying. The first chapter introduces the techniques and the effect of the parameters on the morphology of the nanofiber and nanoparticles and then the subsequent chapters focus on the applications of these techniques in different areas. This book will attract a broad audience including postgraduate students and industrial and academic investigators in sciences and engineering who wish to enhance their understanding of the emerging technologies and use this book as reference.

Author: Sajjad Haider
Publisher: BoD – Books on Demand
ISBN: 9535128213
Category : Science
Languages : en
Pages : 168

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Book Description
This is a timely, an informative, an interesting, and a well-managed book. The book not only offers an in-depth review of the current status of the knowledge of electrospinning and its biomedical applications but also discusses the emerging ideas and features, both from the East and West, with a focus on the needless electrospinning for the production of uniform fibers. The book is equally helpful to the experts of this field, who wish to enhance their understanding of the emerging technologies, and to the new comers, who can use this book as a reference.

Author: Naresh Kasoju
Publisher: Woodhead Publishing
ISBN: 0128224908
Category : Medical
Languages : en
Pages : 484

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Book Description
Biomedical Applications of Electrospinning and Electrospraying describes the principles and laboratory set up for electrospinning and electrospraying, addressing a range of biomedical applications. Sections cover novel combinational approaches, such as electrospinning/spraying and 3D printing. Electrospinning has evolved from being a technique to prepare random networks of textile fibers to a technique to fabricate highly ordered patterns of biomedical materials of defined scale. The technological advancements in recent years with regard to the way the jet is facilitated, how the jet path is controlled, and how the fibers are collected have provided invaluable insights into controlled fabrication of a material of choice. Additionally, the electrospray technique has also evolved from being a technique to prepare food formulations to a technique to prepare cell encapsulated beads for transplantation in clinics. Several innovations in this line, such as those leading to core-shell materials have tremendously changed the way the technique is used. Thus, a combinational approach using electrospinning, electrospraying and 3D printing has emerged. Introduces electrospinning and electrospraying concepts and describes state-of-the-art methodologies Provides comprehensive coverage of electrospun/spray materials in drug delivery, tissue engineering and biosensor applications Presents details of instrumentation involved, along with novel devices for bench to bedside translation, Covers novel combinational approaches using electrospinning, electrospraying and 3D printingIntroduces electrospinning and electrospraying concepts and describes state-of-the-art methodologies Provides comprehensive coverage of electrospun/spray materials in drug delivery, tissue engineering and biosensor applications Presents details of instrumentation involved, along with novel devices for bench to bedside translation Covers novel combinational approaches using electrospinning, electrospraying and 3D printing

Author: Vivek Dave
Publisher: John Wiley & Sons
ISBN: 1119711681
Category : Computers
Languages : en
Pages : 467

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Book Description
The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.

Author: Gareth R. Williams
Publisher: UCL Press
ISBN: 1787350231
Category : Medical
Languages : en
Pages : 244

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Book Description
In recent years there has been an explosion of interest in the production of nanoscale fibres for drug delivery and tissue engineering. Nanofibres in Drug Delivery aims to outline to new researchers in the field the utility of nanofibres in drug delivery, and to explain to them how to prepare fibres in the laboratory. The book begins with a brief discussion of the main concepts in pharmaceutical science. The authors then introduce the key techniques that can be used for fibre production and explain briefly the theory behind them. They discuss the experimental implementation of fibre production, starting with the simplest possible set-up and then moving on to consider more complex arrangements. As they do so, they offer advice from their own experience of fibre production, and use examples from current literature to show how each particular type of fibre can be applied to drug delivery. They also consider how fibre production could be moved beyond the research laboratory into industry, discussing regulatory and scale-up aspects.

Author: Mehdi Afshari
Publisher: Woodhead Publishing
ISBN: 0081009119
Category : Technology & Engineering
Languages : en
Pages : 650

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Book Description
Electrospun Nanofibers covers advances in the electrospinning process including characterization, testing and modeling of electrospun nanofibers, and electrospinning for particular fiber types and applications. Electrospun Nanofibers offers systematic and comprehensive coverage for academic researchers, industry professionals, and postgraduate students working in the field of fiber science. Electrospinning is the most commercially successful process for the production of nanofibers and rising demand is driving research and development in this field. Rapid progress is being made both in terms of the electrospinning process and in the production of nanofibers with superior chemical and physical properties. Electrospinning is becoming more efficient and more specialized in order to produce particular fiber types such as bicomponent and composite fibers, patterned and 3D nanofibers, carbon nanofibers and nanotubes, and nanofibers derived from chitosan. Provides systematic and comprehensive coverage of the manufacture, properties, and applications of nanofibers Covers recent developments in nanofibers materials including electrospinning of bicomponent, chitosan, carbon, and conductive fibers Brings together expertise from academia and industry to provide comprehensive, up-to-date information on nanofiber research and development Offers systematic and comprehensive coverage for academic researchers, industry professionals, and postgraduate students working in the field of fiber science

Author: Dimitrios Lamprou
Publisher: CRC Press
ISBN: 100085714X
Category : Medical
Languages : en
Pages : 269

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Book Description
This book details the advances in drug discovery and delivery and the present need for emerging technologies. Throughout the text new micro and nanofabrication techniques are described, including methods such as electrohydrodynamic processes, additive manufacturing, and microfluidics, which have the potential to produce drug delivery systems that were not possible a few years ago. This book is of great use to both entry-level and experienced researchers in the field of emerging technologies for the manufacturing of drug delivery devices. Features: Describes technologies that are significantly enhancing the delivery of drugs and biologics Presents new data on mobile and wearable point-of-care testing systems Features hot topics such as electrospinning, 3D printing and micro-needles Focuses on additive manufacturing (AM) which can be used to provide customized treatment for patients Will appeal to experienced researchers and those considering entering the field of emerging technologies for the manufacturing of drug delivery devises

Author: Romána Zelkó
Publisher: MDPI
ISBN: 3039281402
Category : Medical
Languages : en
Pages : 206

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Book Description
Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (i.e., high specific surface area, porosity, and the possibility of controlling the crystalline–amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical–chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included.