Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Study of Singly and Doubly Charged Organometallic Complexes PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Study of Singly and Doubly Charged Organometallic Complexes PDF full book. Access full book title Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Study of Singly and Doubly Charged Organometallic Complexes by . Download full books in PDF and EPUB format.
Author: Publisher: ISBN: Category : Languages : en Pages : 42
Book Description
An external source electrospray ionization (ESI) Fourier transform ion cyclotron resonance (FTICR) mass spectrometer has been used to study the organometallic complexes Ag2(DPM)2(BF4)2 (where DPM = bis-diphenylphosphino- methane), Ag2(DPM)3(BF4)2 and Ru(II)(bp)3(PF6)2 (where bpy = 2,2'-bipyridyl). The high mass resolution and accurate mass assignment of parent and collisionally induced dissociation (CID) fragment ions provided structural information on these organometallic complexes. CID in the capillary/skimmer region and inside the FTICR analyzer cell were performed on these complexes and results from each type of experiment were compared. Important fragmentation pathways and reaction types, including bond cleavage, ligand loss, and ligand substitution were identified. Electrospray ionization, Organometallic complexes, Fourier transform ion cyclotron resonance mass spectrometry.
Author: Publisher: ISBN: Category : Languages : en Pages : 42
Book Description
An external source electrospray ionization (ESI) Fourier transform ion cyclotron resonance (FTICR) mass spectrometer has been used to study the organometallic complexes Ag2(DPM)2(BF4)2 (where DPM = bis-diphenylphosphino- methane), Ag2(DPM)3(BF4)2 and Ru(II)(bp)3(PF6)2 (where bpy = 2,2'-bipyridyl). The high mass resolution and accurate mass assignment of parent and collisionally induced dissociation (CID) fragment ions provided structural information on these organometallic complexes. CID in the capillary/skimmer region and inside the FTICR analyzer cell were performed on these complexes and results from each type of experiment were compared. Important fragmentation pathways and reaction types, including bond cleavage, ligand loss, and ligand substitution were identified. Electrospray ionization, Organometallic complexes, Fourier transform ion cyclotron resonance mass spectrometry.
Author: Joseph H. Banoub Publisher: CRC Press ISBN: 1420044036 Category : Medical Languages : en Pages : 506
Book Description
Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustra
Author: Philippe Schmitt-Kopplin Publisher: Elsevier ISBN: 0128140143 Category : Science Languages : en Pages : 778
Book Description
Fundamentals and Applications of Fourier Transform Mass Spectrometry is the first book to delve into the underlying principles on the topic and their linkage to industrial applications. Drs. Schmitt-Kopplin and Kanawati have brought together a team of leading experts in their respective fields to present this technique from many different perspectives, describing, at length, the pros and cons of FT-ICR and Orbitrap. Numerous examples help researchers decide which instruments to use for their particular scientific problem and which data analysis methods should be applied to get the most out of their data. Covers FT-ICR-MS and Orbitrap’s fundamentals, enhancing researcher knowledge Includes details on ion sources, data processing, chemical analysis and imaging Provides examples across the wide spectrum of applications, including omics, environmental, chemical, pharmaceutical and food analysis
Author: Richard B. Cole Publisher: John Wiley & Sons ISBN: 1118211553 Category : Science Languages : en Pages : 900
Book Description
Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION is divided into five parts: Part A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware Part B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces Part C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers Part D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra Part E, Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, Electrospray and MALDI Mass Spectrometry will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry.
Author: Birendra N. Pramanik Publisher: CRC Press ISBN: 1135560439 Category : Science Languages : en Pages : 478
Book Description
Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid sample preconcentration and separation, screening processes for proteins from libraries of compounds, protein folding and dynamics, and more.
Author: Michelle Margaret Sweeney Publisher: ISBN: Category : Languages : en Pages :
Book Description
ABSTRACT: Noncovalent chemistry is the basis of many important biological interactions, including enzyme-ligand complex formation. As these interactions are typically weaker than covalent bonds, special analysis methods are needed for studying noncovalent complexes. Using gentle ionization methods like electrospray ionization (ESI), noncovalent complexes can be preserved and analyzed by mass spectrometry. Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) provides superior mass accuracy, resolving power, and tandemin- time capabilities. Among the dissociation techniques available are in-source collision-induced dissociation and infrared multiple photon dissociation (IRMPD). Dynamic combinatorial chemistry uses a special type of library wherein reversible binding between library members and between library members and a target molecule expands the potential number of strong complex interactions. Here, several 2', 3'-cyclic monophosphate nucleotides were incubated with Ribonuclease A to generate enzyme-ligand complexes. Enzymatic activity may drive the library members to form RNA chains via phosphodiester bond generation. This dissertation shows the method development for screening a cyclic nucleotide-based dynamic combinatorial library for tight-binding ligands of Ribonuclease A using ESI-FTICR-MS.
Author: Richard B. Cole Publisher: Wiley-Interscience ISBN: Category : Science Languages : en Pages : 610
Book Description
Comprehensive, up-to-date coverage of a revolutionary technique Electrospray ionization mass spectrometry (ESI-MS) has completely changed the way physicists, chemists, and biologists view the study of large molecules. The technique derives detailed information about molecular weights and structures from extremely small sample quantities. ESI-MS can create highly charged forms of very high molecular weight compounds, it is naturally compatible with many types of separation techniques, and it allows noncovalent interactions between molecules in solution to be preserved in the gas phase. But many researchers may not use the technique to its full potential because they are unfamiliar with the different perspectives of its underlying processes, the varied approaches to implementation, and the wide-ranging utility of the technique. In this book, Richard B. Cole and an assemblage of leading researchers present a single-volume compilation of different approaches to the understanding and exploitation of ESI-MS. This comprehensive guide: * Examines the physical and chemical aspects of the electrospray process and describes the events involved in ion formation as well as the electro-chemical phenomena that are central to charged droplet formation during the process * Explores the coupling of electrospray ionization to various mass spectrometers, including quadrupole, magnetic, time-of-flight, quadrupole ion trap, and Fourier transform ion cyclotron resonance instruments * Describes recent progress in interfacing ESI with solution-based separation techniques, including liquid chromatography and capillary electrophoresis * Charts the rapid development of ESI applications and categorizes them by compound type: peptides and proteins, nucleic acids and their constituents, carbohydrates and lipids, small molecules related to pharmacology and drug metabolism, and organometallics and inorganic compounds Electrospray Ionization Mass Spectrometry is the indispensable handbook and reference for anyone who wishes to understand, implement, or apply this technique, including researchers in chemistry, metallochemistry, biochemistry, biology, pharmacology, and physics.
Author: 
Author: 
Author: 
Author: Joseph H. Banoub
Author: Brittany L. Heath
Author: Philippe Schmitt-Kopplin
Author: 
Author: Richard B. Cole
Author: Birendra N. Pramanik
Author: Michelle Margaret Sweeney
Author: Richard B. Cole