Electrophysiological investigations of excitation and inhibition in the mammalian central nervous system PDF Download

Author: John David Colin Lambert
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: V. S. Rusinov
Publisher: Springer Science & Business Media
ISBN: 1475750242
Category : Psychology
Languages : en
Pages : 225

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Book Description
This book describes an electrophysiological investigation of foci of excitation in the central nervous system of animals and man, foci which become dominant in character. The dominant focus, or dominant as it is usually called by Russian physiologists, is one of the fundamental processes under lying the activity of the central nervous system. The discovery of the mechanisms of formation of dominant foci is important for a deeper understanding of the activity of the human and animal brain and for identifying the pathophysiological mechanisms in lesions of the nervous system. The book summarizes the results of many years of investiga tion, both experimental and clinical, into the nature and properties of foci of excitation arising at different levels of the central ner vous system. A brief survey of the literature on Ukhtomskii's theory of the dominant is given in Chapter I and the present state of this theory is reviewed. The other chapters of the book deal with the results of research in the field of dominant foci undertaken in the author's laboratory. The experimental data relating to changes in the level of the steady cortical potential during the formation of the dominant focus and conditioned reflex are examined. The results obtained by polarization of the cortex with a weak direct current in order to form a dominant focus, and also by polarization of the reticular system of the brain stem and speCific and nonspecific nuclei of the thalamus and hypothalamus are given.

Author: Matt Carter
Publisher: Academic Press
ISBN: 0323915612
Category : Medical
Languages : en
Pages : 416

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Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more Clear, straightforward explanations of each technique for anyone new to the field A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture Detailed recommendations on where to find protocols and other resources for specific techniques "Walk-through" boxes that guide readers through experiments step-by-step

Author: Ellen Covey
Publisher: Oxford University Press
ISBN: 0199342547
Category : Medical
Languages : en
Pages : 241

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Basic Electrophysiological Methods provides a concise and easy-to-read guide on a selection of the most important contemporary electrophysiological techniques, their implementation, applications, and ways in which they can be combined and integrated with neuroscientific techniques. Intended for students, postdocs, and faculty with a basic neuroscience background, this text will not obscure the relevant technical details with textbook neuroscience tutorials as many other books do. Instead, each chapter provides a conscientious overview of the underlying theory -- a comprehensive description of equipment, materials, methods, data management, and analysis -- a troubleshooting guide, and a list of frequently asked questions. No book or online resource can function as strictly a DIY set of instructions on how to implement a complex technique. However, this book provides a fundamental and accessible set of information intended to form a foundation prior to, during, and after hands-on experience and training, greatly facilitating the initial learning process and subsequent fine-tuning of technical details.

Author: John Huguenard
Publisher: Oxford University Press, USA
ISBN:
Category : Medical
Languages : en
Pages : 92

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This manual and disk, available in IBM PC and Macintosh formats, accompanies Shepherd's Neurobiology, 3/e. It can be used separately even though it is keyed to the textbook. The 17 experiments investigate such areas as the resting membrane potential, action potential, voltage clamp, physiological properties of nerve cells, and synaptic potentials. The program allows students to propagate the action potential, adjust various parameters and observe the effects on nerve cell firing. Students will learn about equilibrium potentials and the effects of changing ion concentrations, as well as passive and active membrane properties. Separate experiments analyze sodium ion and potassium ion currents, the voltage dependence of these currents, and sleep vs. waking in single neurons. Study questions are provided throughout. This ingeniously-designed program will benefit all undergraduate students of neuroscience.

Author: John Barton Furness
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 312

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Author: Eric J. Nestler
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 426

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Considers the role of protein phosphorylation in neuron-specific phenomena. Comprehensively treats the enzymes and molecular biology of phosphorylation and dephosphorylation reactions, examines evidence for the obligatory role of these reactions in neuronal function, and extensively reviews the large number of phosphorylation pathways and their interactions. Original schematic diagrams illustrate principles of the biochemical basis of cell regulation.

Author: Jerome Engel Jr
Publisher: Oxford University Press
ISBN: 019532854X
Category : Medical
Languages : en
Pages : 737

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Book Description
This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.

Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0

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Author: National Research Council
Publisher: National Academies Press
ISBN: 0309045312
Category : Science
Languages : en
Pages : 167

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Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.