Effects of Irradiation and Blast on Pulmonary Funcion in Sheep PDF Download
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Author: John T. Yelverton Publisher: ISBN: Category : Atomic bomb Languages : en Pages : 42
Book Description
The changes in pulmonary function that result following unilateral exposure to LD50 doses of neutron-gamma irradiation and/or sublethal blast overpressures were investigated in sheep. Animals exposed to blast-only and radiation-plus-blast demonstrated large increments in venous admixture on the day of insult followed by a major recovery toward baseline values during the first 24 hours following injury. The venous admixture of the blast-only animals approached baseline 7 days after exposure but that of the radiation-plus-blast sheep did not return to baseline until 21 days. The sheep exposed to radiation-only, blast-only, and radiation-plus-blast sustained similar reduction in means carbon monoxide diffusing capacity (DLCO) which were below that of the control mean at 2 days and 7 days post exposure. All of the radiation-only and radiation-plus-blast sheep that survived to or beyond 21 days displayed an overshoot or recovery to their individual baseline DLCO values. The blast-only and radiation-plus-blast animals also exhibited an increased mean ineffective alveolar ventilation (VAIneff) which persisted from 1 to 14 days following the onset of trauma. The radiation-only sheep had an increased VAIneff from 2 through 7 days post exposure. (Author).
Author: John T. Yelverton Publisher: ISBN: Category : Atomic bomb Languages : en Pages : 42
Book Description
The changes in pulmonary function that result following unilateral exposure to LD50 doses of neutron-gamma irradiation and/or sublethal blast overpressures were investigated in sheep. Animals exposed to blast-only and radiation-plus-blast demonstrated large increments in venous admixture on the day of insult followed by a major recovery toward baseline values during the first 24 hours following injury. The venous admixture of the blast-only animals approached baseline 7 days after exposure but that of the radiation-plus-blast sheep did not return to baseline until 21 days. The sheep exposed to radiation-only, blast-only, and radiation-plus-blast sustained similar reduction in means carbon monoxide diffusing capacity (DLCO) which were below that of the control mean at 2 days and 7 days post exposure. All of the radiation-only and radiation-plus-blast sheep that survived to or beyond 21 days displayed an overshoot or recovery to their individual baseline DLCO values. The blast-only and radiation-plus-blast animals also exhibited an increased mean ineffective alveolar ventilation (VAIneff) which persisted from 1 to 14 days following the onset of trauma. The radiation-only sheep had an increased VAIneff from 2 through 7 days post exposure. (Author).
Author: John T. Yelverton Publisher: ISBN: Category : Languages : en Pages : 32
Book Description
The changes in pulmonary function that result following unilateral exposure to LD50 doses of neutron-gamma irradiation and/or sublethal blast overpressures were investigated in sheep. Animals exposed to blast-only and radiation-plus-blast demonstrated large increments in venous admixture on the day of insult followed by a major recovery toward baseline values during the first 24 hours following injury. The venous admixture of the blast-only animals approached baseline 7 days after exposure but that of the radiation-plus-blast sheep did not return to baseline until 21 days. The sheep exposed to radiation-only, blast-only, and radiation-plus-blast sustained similar reduction in means carbon monoxide diffusing capacity (DLCO) which were below that of the control mean at 2 days and 7 days post exposure. All of the radiation-only and radiation-plus-blast sheep that survived to or beyond 21 days displayed an overshoot or recovery to their individual baseline DLCO values. The blast-only and radiation-plus-blast animals also exhibited an increased mean ineffective alveolar ventilation (VAIneff) which persisted from 1 to 14 days following the onset of trauma. The radiation-only sheep had an increased VAIneff from 2 through 7 days post exposure. (Author).
Author: Edward G. Damon Publisher: ISBN: Category : Languages : en Pages : 46
Book Description
Pulmonary function tests were conducted before and after exposure of animals to air blasts produced in shock tubes or by high explosives. Pressure- time measurements were made with piezoelectric pressure transducers during each air-blast exposure. Blood samples were obtained without anesthesia from an indwelling arterial catheter. The blood PO2, PCO2, and pH and the end-tidal and mixed expired CO2, O2, and N2 gas concentrations were measured for subjects breathing air and oxygen. There were increases in the alveolar-arterial O2 differences and venous admixture which generally correlated with the extent of blast-induced lung damage. The threshold for lung injury resulting in increased venous admixture in sheep was about 20 psi for reflected overpressures of 'long' duration. Pressures above 43 psi usually caused severe lung damage in which the venous-arterial shunt exceeded 30 percent of the cardiac output, a condition in which the arterial oxygen tension was below the level required for full saturation of the hemoglobin even with animals breathing pure oxygen.
Author: John T. Yelverton
Author: John T. Yelverton
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Author: John T. Yelverton
Author: Edward G. Damon
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