Encyclopedia of AIDS PDF Download

Author: Thomas J. Hope
Publisher:
ISBN: 9781461496106
Category : AIDS (Disease)
Languages : en
Pages :

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Author: Guido Silvestri
Publisher: Springer
ISBN: 303002816X
Category : Medical
Languages : en
Pages : 253

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Book Description
This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

Author: Marie H. Kosco-Vilbois
Publisher: Springer Science & Business Media
ISBN: 3642796036
Category : Medical
Languages : en
Pages : 215

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Book Description
Follicular dendritic cells (FOe) are unique among cells of the immune system. While their morphological characteristics re sulted in their inclusion as a 'dendritic cell type', tt1ey differ quite significantly from the other members of the dendritic cell family. In contrast to T-cell-associated dendritic cells or the Langerhans cells found in the skin, FOe reside in highly organized B cell follicles within secondary lymphoid tissues. This site of resi dence provided a nomenclature committee in 1982 with the second descriptive factor for the derivation of their name. The cardinal feature of FOe is to trap and retain antigen on the surface of their dendritic processes for extended amounts of time and it is this feature that provides the conceptual compo nent for the title of this book. In response to an antigenic challenge, primary B cell follicles undergo dynamic events, giving rise to germinal centers which are associated with activation, expansion, and differentiation processes of B cells. The interactions of B cells with Foe and T cells in the germinal centers are essential for generating the complete repertoire of antibody isotypes obtained during an antibody response. In addition, stimuli either initiated or main tained during the germinal center reponse leads to production of high affinity antibodies through the processes of somatic muta tion and clonal selection. In this context, FOe act as a pivotal source of antigen. They accumulate foreign proteins (e. g.

Author: R. Ahmed
Publisher: Wiley-Blackwell
ISBN:
Category : Medical
Languages : en
Pages : 754

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Book Description
Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.

Author: Marcel B.M. Teunissen
Publisher: Springer Science & Business Media
ISBN: 3642236901
Category : Medical
Languages : en
Pages : 262

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Book Description
This volume of Current Topics in Microbiology and Immunology covers diverse topics related to intradermal immunization. The chapters highlight the effectiveness of intradermal immunization in experimental animal models or in clinical practice, all supporting the view that intradermal immunization is at least as good as other immunization routes. Keeping in mind that current vaccines are not specially designed for intradermal immunization, but show comparable efficiency even at reduced dosages, this underlines the great potential for the skin as a vaccination site. Hopefully, the overview in this volume will encourage vaccine designers to focus on this promising immunization route, and in addition, to inspire them to develop vaccines that are especially optimized for intradermal immunization.

Author: Jonathan Soboloff
Publisher: CRC Press
ISBN: 149870509X
Category : Medical
Languages : en
Pages : 258

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Book Description
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Author: John E. Bennett
Publisher: Elsevier Health Sciences
ISBN: 1437720609
Category : Medical
Languages : en
Pages : 4306

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Book Description
After thirty years, PPID is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. Mandell, Bennett, and Dolin have substantially revised and meticulously updated, this new edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 7th Edition helps you identify and treat whatever infectious disease you see. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Get the answers to questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you’ll find in any other infectious disease resource. Find the latest diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on influenza (new pandemic strains); new Middle East respiratory syndrome (MERS) virus; probiotics; antibiotics for resistant bacteria; antifungal drugs; new antivirals for hepatitis B and C; Clostridium difficile treatment; sepsis; advances in HIV prevention and treatment; viral gastroenteritis; Lyme disease; Helicobacter pylori; malaria; infections in immunocompromised hosts; immunization (new vaccines and new recommendations); and microbiome. Benefit from fresh perspectives and global insights from an expanded team of international contributors. Find and grasp the information you need easily and rapidly with newly added chapter summaries. These bulleted templates include diagnosis, therapy, and prevention and are designed as a quick summary of the chapter and to enhance relevancy in search and retrieval on Expert Consult. Stay current on Expert Consult with a thorough and regularly scheduled update program that ensures access to new developments in the field, advances in therapy, and timely information. Access the information you need easily and rapidly with new succinct chapter summaries that include diagnosis, therapy, and prevention. Experience clinical scenarios with vivid clarity through a richly illustrated, full-color format that includes 1500 photographs for enhanced visual guidance.

Author: Hiroshi Kiyono
Publisher: Elsevier
ISBN: 0080537057
Category : Medical
Languages : en
Pages : 501

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Book Description
This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization

Author: Constantinos Petrovas
Publisher: Frontiers Media SA
ISBN: 2889457583
Category :
Languages : en
Pages : 186

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Book Description
Currently, more than 36 million people are infected with HIV. Although the introduction of highly active anti-retroviral therapy (HAART) has led to substantial advances in the clinical management of HIV infected individuals, HAART cannot completely eliminate the virus. This is because CD4 T helper cells, harboring the virus, remain dormant reservoirs. These reservoirs are difficult to measure and are present even in HAART-treated HIV infected individuals with undetectable levels of HIV in the blood. A growing body of studies has revealed follicular helper (Tfh) CD4 T cells, a highly differentiated CD4 T cell population localized in immunologically sanctuary sites (follicle/germinal center), as a major reservoir of HIV. The present Frontiers in Immunology eBook compiles 16 timely review articles focusing on the dynamics of major follicular immune cell types in HIV/SIV infection and their potential role for disease pathogenesis and the viral persistence in the lymph node. This eBook provides a comprehensive presentation of recent published work on lymph node and especially Tfh cell dynamics in HIV infection and we hope that it will be useful for our further understanding of how such dynamics affect the interplay between virus and host as well as for the discovery of novel therapeutic targets in the fight against HIV.

Author: Jean-Marie Andrieu
Publisher: Springer Science & Business Media
ISBN: 1461519950
Category : Medical
Languages : en
Pages : 246

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Book Description
In the past decade, the global efforts in the control of HIV disease were basically concentrated on the search for anti-retroviral agents. So far, anti-HIV therapies have been shown to be disappointing because of rapid development of drug-resistant mutant variants. Despite this drawback in the therapeutic fight against HIV infection, antiviral research should be actively pursued. However, failure of antiviral therapy indicates that other avenues of research should be rapidly explored with the same energy. In this setting, striking advances have been recently made in the dissection and understanding of the viro-immunological processes governing the progressive destruction of lymphoid organs associated with AIDS develop ment, and HIV-induced activation and apoptosis have been identified as key phenomena of the immune system destruction. This book assembles the most recent advances on basic and clinical aspects ofT-cell activationiapoptosis in HIV infection and their implications for immunotherapy. These data were presented at an international symposium held on July 11-12, 1994, in Paris. The book is partitioned into 21 chapters covering four comprehensive fields: 1) T-celllmacrophage activation and HIV infection; 2) Apoptosis and viropathogenesis of HI V disease; 3) Apop tosis and immunopathogenesis ofHIV disease; 4) Mediators ofT-cell activationiapoptosis and therapeutic applications. We hope that this book will assist the readers in understanding recent advances in the viro-immunopathogenesis of HI V disease as well as the rationales for potential immune cell-targeted therapeutic interventions.