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Author: Publisher: ISBN: Category : Audiology Languages : en Pages : 34
Book Description
The acoustic startle response (ASR) is a reliable reflexive behavioral response in mammals elicited by an unexpected intense acoustic startle eliciting stimulus (SES). It is mediated by a sub-cortical pathway that includes the inferior colliculus (IC). The ASR amplitude can be measured with an accelerometer beneath the subject attached to the cage, and can be decreased in amplitude by presenting a less intense, non-startling stimulus 20-300 ms before the SES. This reflexive decrement in ASR is called pre pulse inhibition (PPI) and indicates that the relatively soft pre pulse was heard. Murine species have been used to study this response for psychoacoustical estimates of hearing thresholds and to understand the effects of genetic mutations on the ASR, PPI and the afferent auditory neural pathway. The Eph/ephrin signaling pathway is known to be important in directing developing auditory afferents, including connections to various subdivisions of the IC. In this experiment, we measured the effect of Eph/ephrin mutations on PPI in mice with a control strain (C57BL/6J), a strain with compromised EphA4 signaling (EphA4lacZ), and a knockout ephrin-B3 strain (ephrin-B3null). The control strain and EphA4lacZ strain showed robust PPI (up to 75% decrement in ASR) to an offset of a 70dB SPLrms background noise at 50ms before the SES. Ephrin-B3 knockout mice were only marginally significant in PPI (
Author: Publisher: ISBN: Category : Audiology Languages : en Pages : 34
Book Description
The acoustic startle response (ASR) is a reliable reflexive behavioral response in mammals elicited by an unexpected intense acoustic startle eliciting stimulus (SES). It is mediated by a sub-cortical pathway that includes the inferior colliculus (IC). The ASR amplitude can be measured with an accelerometer beneath the subject attached to the cage, and can be decreased in amplitude by presenting a less intense, non-startling stimulus 20-300 ms before the SES. This reflexive decrement in ASR is called pre pulse inhibition (PPI) and indicates that the relatively soft pre pulse was heard. Murine species have been used to study this response for psychoacoustical estimates of hearing thresholds and to understand the effects of genetic mutations on the ASR, PPI and the afferent auditory neural pathway. The Eph/ephrin signaling pathway is known to be important in directing developing auditory afferents, including connections to various subdivisions of the IC. In this experiment, we measured the effect of Eph/ephrin mutations on PPI in mice with a control strain (C57BL/6J), a strain with compromised EphA4 signaling (EphA4lacZ), and a knockout ephrin-B3 strain (ephrin-B3null). The control strain and EphA4lacZ strain showed robust PPI (up to 75% decrement in ASR) to an offset of a 70dB SPLrms background noise at 50ms before the SES. Ephrin-B3 knockout mice were only marginally significant in PPI (
Author: Wim E. Crusio Publisher: Cambridge University Press ISBN: 1107355575 Category : Science Languages : en Pages : 361
Book Description
The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Author: Carolyn A. Staton Publisher: John Wiley & Sons ISBN: 047002934X Category : Medical Languages : en Pages : 410
Book Description
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Author: Anna Menini Publisher: CRC Press ISBN: 1420071998 Category : Science Languages : en Pages : 438
Book Description
Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely
Author: Carlo Sala Publisher: Academic Press ISBN: 0128005335 Category : Medical Languages : en Pages : 396
Book Description
Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. - Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities - Describes the genes implicated in autistic spectrum disorders and their function - Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies - Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture
Author: Jun Chen Publisher: Springer Science & Business Media ISBN: 1603271856 Category : Medical Languages : en Pages : 490
Book Description
Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation. Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.
Author: Rob Krams Publisher: Oxford University Press ISBN: 0198755775 Category : Medical Languages : en Pages : 347
Book Description
The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.
Author: Helmut L. Haas Publisher: Springer Science & Business Media ISBN: 364273202X Category : Medical Languages : en Pages : 219
Book Description
This is the second time that I have had the honor of opening an interna tional symposium dedicated to the functions of the hippocampus here in Pecs. It was a pleasure to greet the participants in the hope that their valuable contributions will make this meeting a tradition in this town. As one of the hosts of the symposium, I had the sorrowful duty to remind you of the absence of a dear colleague, Professor Graham God dard. His tragic and untimely death represents the irreparable loss of both a friend and an excellent researcher. This symposium is dedicated to his memory. If I compare the topics of the lectures of this symposium with those of the previous one, a striking difference becomes apparent. A dominating tendency of the previous symposium was to attempt to define hippocam pal function or to offer data relevant to supporting or rejecting existing theoretical positions. No such tendency is reflected in the titles of the present symposium, in which most of the contributions deal with hip pocampal phenomena at the most elementary level. Electrical, biochemi cal, biophysical, and pharmacological events at the synaptic, membrane, or intracellular level are analyzed without raising the question of what kind of integral functions these elementary phenomena are a part of.
Author: Per Andersen Publisher: Oxford University Press ISBN: 9780195100273 Category : Medical Languages : en Pages : 892
Book Description
The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.
Author: Deric L. Wheeler Publisher: Springer ISBN: 1493920537 Category : Science Languages : en Pages : 452
Book Description
Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family. Receptor Tyrosine Kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases. And over the last decade they have become the Number 1 targets of cancer drugs. To be able to conduct fundamental research or to attempt to develop pharmacological agents able to enhance or intercept them, it is essential first to understand the evolutionary origin of the 58 RTKs and their roles in invertebrates and in humans, as well as downstream signaling pathways. The assembly of chapters is written by experts and underscores commonalities between and among the RTKs. It is an ideal companion volume to The Receptor Tyrosine Kinase: Families and Subfamilies, which proceeds, family by family through all of the specific subfamilies of RTKs, along with their unique landmarks.
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Author: Wim E. Crusio
Author: Carolyn A. Staton
Author: Anna Menini
Author: Carlo Sala
Author: Jun Chen
Author: Rob Krams
Author: Helmut L. Haas
Author: Per Andersen
Author: Deric L. Wheeler