Effect of Mixing on Crystallization in a Continuous Agitated Suspension Crystallizer PDF Download

Author: Sameer Ramesh Deshpande
Publisher:
ISBN:
Category :
Languages : en
Pages : 192

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Author: Alan G. Jones
Publisher: Butterworth-Heinemann
ISBN: 0750655208
Category : Science
Languages : en
Pages : 362

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Particulate Crystal Characteristics; Fluid-particle Transport Processes; Crystallization Principles and Techniques; Crystal Formation Processes; Crystallizer Design and Operation; Solid-Liquid Separation Processes; Design of Crystallization Process Systems.

Author: Allan Myerson
Publisher: Butterworth-Heinemann
ISBN: 0080533515
Category : Technology & Engineering
Languages : en
Pages : 329

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Book Description
Crystallization is an important separation and purification process used in industries ranging from bulk commodity chemicals to specialty chemicals and pharmaceuticals. In recent years, a number of environmental applications have also come to rely on crystallization in waste treatment and recycling processes.The authors provide an introduction to the field of newcomers and a reference to those involved in the various aspects of industrial crystallization. It is a complete volume covering all aspects of industrial crystallization, including material related to both fundamentals and applications. This new edition presents detailed material on crystallization of biomolecules, precipitation, impurity-crystal interactions, solubility, and design.Provides an ideal introduction for industrial crystallization newcomers Serves as a worthwhile reference to anyone involved in the fieldCovers all aspects of industrial crystallization in a single, complete volume

Author: Bhaskar Sen Gupta
Publisher: Springer Science & Business Media
ISBN: 9401722900
Category : Science
Languages : en
Pages : 333

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Book Description
We are honoured to present this collection of selected papers from the International Conference on Mixing and Crystallization, held at the Tioman Island, Malaysia in April, 1998. We are grateful to the editorial board comprising five eminent researchers in the field of mixing and crystallization for their thoughtful review and suggestions. In order to make this book as current as possible some of the papers have been thoroughly revised, which caused some delay in bringing out this edited version. We received necessary support from the Institute of Post Graduate Studies and Research, the University of Malaya and the Special Research Centre for Multiphase Processes, and the University of Newcastle, Australia in organizing this conference. We are indebted to the Institute of Chemical Engineers, United Kingdom, and the Institution of Engineers, Malaysia for their sponsorship. We would like to thank K.C. Lim, Dr. C. Ramakanth and Ms. Zubaidah for their help at the various stages of editing. We would also like to express our gratitude to Professor Mohd. Ali Hashim and Dr. Nafis Ahmed for their help and encouragement. Finally, I would like to thank Kluwer Academic Publishers for publishing this book. Bhaskar Sen Gupta Shaliza Ibrahim University of Malaya, Kuala Lumpur xi CFD MODELLING OF HYDRODYNAMIC CONDITIONS WITHIN THE WAKE OF MIXING IMPELLER BLADES 1 G.D. RIGByl., G. LANE . AND G.M. EVANSl.

Author: Peter Kleinebudde
Publisher: John Wiley & Sons
ISBN: 1119001323
Category : Science
Languages : en
Pages : 645

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A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.

Author: Nima Yazdanpanah
Publisher: Royal Society of Chemistry
ISBN: 1839161310
Category : Technology & Engineering
Languages : en
Pages : 579

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Book Description
Continuous crystallization is an area of intense research, with particular respect to the pharmaceutical industry and fine chemicals. Improvements in continuous crystallization technologies offer chemical industries significant financial gains, through reduced expenditure and operational costs, and consistent product quality. Written by well-known leaders in the field, The Handbook of Continuous Crystallization presents fundamental and applied knowledge, with attention paid to application and scaling up, and the burgeoning area of process intensification. Beginning with concepts around crystallization techniques and control strategies, the reader will learn about experimental methods and computational tools. Case studies spanning fine and bulk chemicals, the pharmaceutical industry, and employing new mathematical tools, put theory into context.

Author: A. Mersmann
Publisher: CRC Press
ISBN: 0203908287
Category : Science
Languages : en
Pages : 849

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Book Description
This handbook facilitates the selection, design and operation of large-scale industrial crystallizers that process crystals with the proper size distribution, shape and purity sought - including cooling, evaporation, drowning-out reaction, melt, and related crystallization techniques. This new edition offers new results on direct-contact cooling crystallization. It lists the properties of over 170 organic and inorganic crystallization systems.

Author: J. Mullin
Publisher: Springer Science & Business Media
ISBN: 1461572584
Category : Science
Languages : en
Pages : 457

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Book Description
Industrial Crystallization Symposia have been organized by the Crystallization Research Group at the Czechoslovak Research Institute for Inorganic Chemistry, Usti nad Labem, since 1960. Over the years, the increasing popularity of the unit operation of crystallization has been clearly demonstrated by the steady increase in numbers of both the papers presented and the attendances at the meetings. The 6th Symposium (1-3 September 1975) was organized jointly with the European Federation of Chemical Engineering Working Party on Crystallization, and the 44 papers presented were arranged into four sessions - A: Secondary Nucleation, B: Crystal Growth Kinetics, C: Crystal Habit Modification, D: Crystallizer Design, E: Indus trial Crystallizer Operation and Case Studies. The same groupings are preserved in this edited version of the proceedings. This is the first time that the Industrial Crystallization Symposium papers have appeared in one volume. After the 5th (1972) Symposium, authors we.re encouraged to submit their papers to an international journal specializing in crystallization. However, the results were not altogether satisfactory in that less than one third of the papers presented at the meeting were offered for consideration. This time, therefore, the organizing committee decided to attempt to keep the papers together by making arrangements for their pUblication by Plenum Press.

Author: E. Kougoulos
Publisher:
ISBN:
Category :
Languages : en
Pages : 594

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Book Description
This thesis is concerned with the development of a predictive model for batch cooling suspension pharmaceutical crystallizations, with a focus on product performance. A major challenge involved in the design of industrial pilot plant pharmaceutical crystallizers, is to predict the influence of crystallizer geometry, scale and operating conditions on the process behaviour and crystal size distribution (CSD). The design of industrial crystallizers is hindered by the lack of scale-up rules due to the absence of reliable predictive process models. Currently no reliable predictive or 'dial up a particle size' tool exists for scale-up predictions. The research involves the development of a novel predictive compartmental modelling framework for the scale-up of an organic fine chemical. A new approach of using compartments is developed in order to facilitate scale-up design and process modelling by separating crystallization kinetic and hydrodynamic phenomena. Application of this technique involves determining key process engineering information on a laboratory scale, which is critical for technology transfer, and combining this data with hydrodynamic information on transfer to large scale for predictive scale-up purposes. The key process engineering information required for predictive modelling includes the determination of solubility characteristics, thermodynamic properties and crystallization kinetics of the organic fine chemical. Attenuated Total Reflectance Ultra-Violet (ATR-UV) spectroscopy is used as an 'in-situ' measurement technique to measure solute concentration. A modified continuous Mixed Suspension Mixed Product Removal (MSMPR) crystallizer is designed specifically for innovative drug candidates available in limited quantities to derive steady state crystallization kinetics with minimal influence from hydrodynamic phenomena. Batch attrition experiments were carried out to determine the effects of specific power input on the CSD using Lasentec Focussed Beam Reflectance Monitoring (FBRM) to monitor the process on-line and to develop an attrition rate model. Computational Fluid Dynamics (CFD) is a simulation tool that is also introduced to provide valuable insight into mixing, heat transfer and hydrodynamic phenomena within agitated batch cooling suspension crystallization vessels including investigating the effects of scale-up. CFD is used to aid the development of the compartmental modelling framework. The design of the compartmental structure is based on high spatial resolution CFD simulations of internal flow, mixing and heat transfer within crystallizers upon scale-up. The great advantage of using a compartmental modelling framework is that the spatial resolution is reduced and the full population balance with kinetic models can be implemented. The detailed compartmental framework is based on the overall flow pattern, local energy dissipation rate, solids concentration and temperature distribution obtained from CFD. The number, location, cross-sectional area and volume of compartments are determined from CFD results based on the physical crystallizer dimensions. The compartments are selected such that they have approximately uniform temperature, local energy dissipation and solids concentration. Each dynamic compartment has a mass, concentration, enthalpy and population balance combined with MSMPR crystallization kinetic models. The compartments are therefore well mixed and physically connected via interconnecting flows determined from CFD. A general process modelling tool, gPROMS (Process Systems Enterprises) that supports both steady state and dynamics simulations is used to solve sets of ordinary differential and algebraic equations in each compartment. A single compartmental modelling approach is used initially as a first approach without taking into account local variations in process conditions. Predictions on a laboratory scale for an MSMPR and batch cooling crystallizer were satisfactory but upon scale-up the effects of mixing and hydrodynamics is not taken into account and therefore the predictions become less reliable. A compartmentalization approach can be introduced into gPROMS whereby the compartments are modelled as individual units with input and output streams using CFD hydrodynamic information.

Author: J W Mullin
Publisher: Elsevier
ISBN: 0080530117
Category : Technology & Engineering
Languages : en
Pages : 611

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Book Description
Since the first publication of this definitive work nearly 40 years ago, this fourth edition has been completely rewritten. Crystallization is used at some stage in nearly all process industries as a method of production, purification or recovery of solid materials. Incorporating all the recent developments and applications of crystallization technology, Crystallization gives clear accounts of the underlying principles, a review of the past and current research themes and guidelines for equipment and process design. This new edition introduces and enlarges upon such subjects as: - Control and Separation of polymorphs and chiral crystals - Micro- and macro-mixing and the use of computer fluid dynamics - Seeding and secondary nucleation in batch crystallization processes - Incorporation of upstream and downstream requirements into design procedures for crystallization plant - Computer-aided molecular design and its use in crystal habit modifier selection Crystallization provides a comprehensive overview of the subject and will prove invaluable to all chemical engineers and industrial chemists in the process industries as well as crystallization workers and students in industry and academia. Crystallization is written with the precision and clarity of style that is John Mullin's hallmark - a special feature being the large number of appendices that provide relevant physical property data. - Covers all new developments and trends in crystallization - Comprehensive coverage of subject area