Economic Evaluation of Glycoprotein IIb/IIIa Inhibitors in Patients Undergoing Percutaneous Coronary Intervention with Stenting PDF Download

Author:
Publisher:
ISBN: 9781894978620
Category : Platelet glycoprotein GPIIb-IIIa complex
Languages : en
Pages : 78

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Book Description

Author: A. Michael Lincoff
Publisher: Springer Science & Business Media
ISBN: 1592597246
Category : Medical
Languages : en
Pages : 415

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Book Description
In Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease, the major investigators working in this rapidly advancing field join together under the aegis of A. Michael Lincoff and Eric J. Topol to provide the first comprehensive overview of the preclinical and clinical development of the glycoprotein IIb/IIIa receptor antagonists. These acknowledged experts elucidate the theoretical basis for the inhibition of platelet aggregation in the treatment of coronary syndromes, present and synthesize evidence for the efficacy of glycoprotein IIb/IIIa blockade in inhibiting ischemic complications of both coronary intervention and acute coronary syndromes, and provide guidelines for the use of this novel class of agents in the clinical management of cardiovascular disease. They also compare the pharmacology and clinical efficacy of the currently available glycoprotein IIb/IIIa receptor inhibitors and speculate about further potential applications of these agents in the treatment of vascular disease. Written by the scientists and physicians who discovered and characterized this important new class of receptors, invented the first IIb/IIIa agents, and conducted the definitive clinical trials, Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease offers the most complete and authoritative review of these powerful new therapeutics available today.

Author:
Publisher:
ISBN: 9781894978552
Category : Blood platelets
Languages : en
Pages : 72

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Book Description

Author: Timothy J Watson
Publisher: Springer
ISBN: 9811311145
Category : Medical
Languages : en
Pages : 338

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Book Description
This book is open access under a CC BY 4.0 license. This quick-reference handbook offers a concise and practical review of key aspects of the treatment of ST-segment elevation myocardial infarction (STEMI) in the era of primary percutaneous coronary intervention (PPCI). In the context of STEMI, PPCI is the preferred mode of emergency revascularization. Access to PPCI is rapidly increasing and is now routinely practiced in both general and specialist hospitals and there has been a recent emphasis on developing STEMI networks to enhance and expedite the referral pathway. This coupled with concurrent developments to enhance the safety and efficacy of the PPCI procedure has heralded an era where STEMI interventions are increasingly considered an important subspecialty within interventional cardiology. Written by leading cardiologists who have been instrumental in the adoption of PPCI in their respective institutions, the book provides junior and senior cardiologists alike with insightful and thought-provoking tips and tricks to enhance the success of PPCI procedures, which may in turn translate into direct improvements in outcomes. The book is also relevant for healthcare providers and emergency department physicians.

Author: Nathalie Eckard
Publisher: Linköping University Electronic Press
ISBN: 9175191423
Category : Atrial fibrillation
Languages : en
Pages : 131

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Book Description
Economic evaluations are used to inform decision makers about the efficient allocation of scarce healthcare resources and are generated with the direct intent to support decisions in healthcare. Producing guidelines is a complex process and the inclusion of health-economic aspects in the formulation of the Swedish national guidelines as a basis for the written recommendations (priority gradings), distinguishes them from their European counterparts. Despite the increased use of cost-effectiveness data in decision-making, little is known about the actual use of such data. This thesis covers issues concerning how economic evaluations matter in health policy decision-making. The thesis includes four papers based on the Swedish national guidelines for heart diseases, one of the most prominent examples in Sweden of following the notion of evidence-based policy (EBP), in order to inform explicit priority setting. Both Papers I and II followed a qualitative case study design, based on the same data set. Paper I explored how a specific working group, the Priority Setting Group (PSG), handled the various forms of evidence and values when producing the national guidelines. Two themes were identified in reaching collective agreement in priority gradings; group facilitation activities and avoiding deadlock in the discussion. The work process involved disagreement and negotiation as part of that task. Paper I contributes to the theoretical and practical debate on EBP. Paper II focused on the use of cost-effectiveness data as decision support in the PSG work process. The paper addressed availability of cost-effectiveness data, evidence understanding, interpretation difficulties, and the reliance on evidence. Three themes were identified. The paper contributes to knowledge on how cost-effectiveness evidence was used in actual decision-making. The use of cost-effectiveness evidence was one of many tools employed to avoid deadlock in discussion and to reach a priority grading, when the overall evidence base was weak, in times of uncertainty and on the introduction of new expensive medical technologies. Quantitative research methods were used for both Papers III and IV. Paper III explored how the PSG was presented with cost-effectiveness evidence as decision support and as a basis for their priority gradings. Cost-effectiveness ratios (ICERs) were provided, based on a systematic literature review, as well as how the results may be conveyed and communicated, for the treatment of heart diseases using a cost-effectiveness ranking or league and providing valid information within a limited space, aiding decision makers on the allocation of healthcare resources. The thesis also includes decision support in the form of cost-effectiveness analysis on catheter ablation treatment. Paper IV provides an example of presenting evidence in the form of a decision-analytic model. The modelling approach provides an analytic framework for decision-making, specifically under conditions of uncertainty as in the introduction of new medical technology. Catheter ablation was associated with reduced cost and an incremental gain in quality adjusted life years (QALYs), and was considered a cost-effective treatment strategy compared to the medical treatment strategy in a lifetime perspective.

Author: Annapoorna Kini
Publisher: Springer
ISBN: 1447165810
Category : Medical
Languages : en
Pages : 297

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Book Description
This practical handbook is based on an internal working manual developed by staff and fellows at Mount Sinai Heart Cardiovascular Catheterization Laboratory, renowned for its high-volume and low complication complex coronary procedures. The Practical Handbook of Interventional Cardiology captures the knowledge and methodological know-how from leaders in interventional cardiology, it intends to guide users in a stepwise, methodical and practical approach through various cardiac interventional procedures in order to achieve maximum patient safety and improved outcomes. From patient selection, preoperative work-up, setting up equipment to step-by-step illustrations of various procedural details and troubleshooting, this handbook captures all the details necessary to perform the simplest to the most complex cardiac interventions. The book is designed for cardiologists and trainees who desire an efficient way to review the steps of various cardiac interventional procedures and a quick, reliable reference for everyday use.

Author: Yoshinobu Onuma
Publisher: CRC Press
ISBN: 1498779778
Category : Medical
Languages : en
Pages : 533

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Book Description
This book focuses on the coronary bioresorbable scaffold, a new interventional treatment for coronary artery disease, differentiated from a permanent metallic stent. The book provides an overview of the technology including non-clinical studies and clinical evidences in order to help clinicians understand the appropriate application of the technology and the optimal techniques of implantation. It covers the basics of bioresorbable scaffolds; bench test results; preclinical studies; clinical evidences; and tips and tricks of implantation.

Author: A. Michael Lincoff
Publisher: Springer Science & Business Media
ISBN: 1592593763
Category : Medical
Languages : en
Pages : 471

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Book Description
This substantially revised second edition contains new chapters on the role of GPIIb/IIIa blockade during acute coronary syndromes or with fibrinolytic therapy during acute myocardial infarctions, and updated and expanded information on the latest trials of GP IIb/IIIa inhibition during percutaneous coronary intervention. Additional improvements include a new chapter on outcomes with chronic oral GP IIb/IIIa blockade following acute coronary syndromes, discussion of GPIIb/IIIa blockade with other platelet and thrombin inhibitors, and a review of the potential effects beyond inhibition of platelet aggregation.

Author: William S. Weintraub
Publisher: Springer Science & Business Media
ISBN: 1592593984
Category : Medical
Languages : en
Pages : 439

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Book Description
An illuminating and timely synthesis of methodological and clinical studies showing how medical costs can be established, how the value of clinical outcomes can be assessed, and how difficult choices can be rationally made. The methodological chapters review the conceptual and practical issues involved in estimating and interpreting health care costs, making health status and utility assessments, and statistically analyzing cost-effectiveness and clinical trials. The clinical chapters apply these methods to the major clinical areas of cardiology-primary prevention of coronary artery disease, acute coronary syndromes, angioplasty vs coronary bypass surgery, CABG vs medicine, congestive heart failure, arrhythmias, and cardiac surgery. Additional chapters consider the use of economic studies for policy purposes and the future of Medicare under a balanced budget in an aging America.

Author: Eric J. Topol, MD
Publisher: Elsevier Health Sciences
ISBN: 0323340385
Category : Medical
Languages : en
Pages : 1114

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Book Description
Ideal for cardiologists, surgeons, and referring physicians who need a clinical guide to interventional procedures, Textbook of Interventional Cardiology focuses on the latest treatment protocols for managing heart disorders at every level of complexity. In this updated edition, Dr. Topol continues to bring together experts in the field who present the current state of knowledge and clinical practice in interventional cardiology, including cutting-edge theories, trends, and applications of diagnostic and interventional cardiology, as well as peripheral vascular techniques and practices. Offers an in-depth understanding of cardiology, making it well suited for cardiology and interventional cardiology exam preparation. Expert guidance from leading authorities ensures a fresh and balanced perspective on every aspect of interventional cardiology. Presents the most recent genetic information and clinical trials related to interventional cardiology. Highlights the latest treatment advances, procedures, devices, and techniques, including transcatheter aortic valve implantation (TAVI). Brand-new chapters include Radiation Safety, Renal Denervation for Resistant Hypertension, Post PCI Hospitalization, Length of Stay and Discharge Planning, and Interventional Heart Failure. Offers balanced coverage of the entire scope of technologies available, without favoring one particular device over another. Integrates the latest trial data into discussions on clinical practice and recommendations. Multiple images of devices and intra-procedural imaging enhance your visual understanding of the material. Key Points boxes at the beginning of each chapter summarize the most important facts. Features 45 videos easily accessible via Expert Consult. Expert Consult eBook version included with purchase. This enhanced eBook experience offers access to all of the text, figures, videos, and references from the book on a variety of devices.