Author: National Institute of Mental Health (U.S.)Publisher:
ISBN:
Category :
Languages : en
Pages : 140
Book Description
Early Clinical Drug Evaluation Units, and Analysis, Sample Output Package
Author: National Institute of Mental Health (U.S.)Publisher:
ISBN:
Category :
Languages : en
Pages : 140
Book Description
Small Clinical Trials
Author: Institute of MedicinePublisher: National Academies Press
ISBN: 0309171148
Category : Medical
Languages : en
Pages : 221
Book Description
Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
The Documentation of Clinical Psychotropic Drug Trials: Sample output package
Author: National Institute of Mental Health (U.S.). Psychopharmacology Research BranchPublisher:
ISBN:
Category : Antidepressants
Languages : en
Pages : 140
Book Description
The Documentation of Clinical Psychotropic Drug Trials
Author: National Institute of Mental Health (U.S.). Psychopharmacology Research BranchPublisher:
ISBN:
Category : Psychopharmacology
Languages : en
Pages : 140
Book Description
Monthly Catalog, United States Public Documents
Author: United States. Superintendent of DocumentsPublisher:
ISBN:
Category : Government publications
Languages : en
Pages : 1282
Book Description
February issue includes Appendix entitled Directory of United States Government periodicals and subscription publications; September issue includes List of depository libraries; June and December issues include semiannual index
Psychopharmacology Bulletin
Author: The Documentation of Clinical Psychotropic Drug Trails
Author: Thomas H. McGlashanPublisher:
ISBN:
Category : Drugs
Languages : en
Pages : 146
Book Description
Author: 
Author: Jerome Levine
Author: