DNA Polymorphisms: DNA-Based Molecular Markers and Their Application in Medicine PDF Download

Author: Salwa Teama
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages :

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Book Description
DNA polymorphisms are the different DNA sequences among individuals, groups, or populations. Polymorphism at the DNA level includes a wide range of variations from single base pair change, many base pairs, and repeated sequences. Genomic variability can be present in many forms, including single nucleotide polymorphisms (SNPs), variable number of tandem repeats (VNTRs, e.g., mini- and microsatellites), transposable elements (e.g., Alu repeats), structural alterations, and copy number variations. Different forms of DNA polymorphisms can be tracked using a variety of techniques; some of these techniques include restriction fragment length polymorphisms (RFLPs) with Southern blots, polymerase chain reactions (PCRs), hybridization techniques using DNA microarray chips, and genome sequencing. During the last years, the recent advance of molecular technologies revealed new discoveries of DNA polymorphisms. DNA polymorphisms are endless, and more discoveries continue at a rapid rate. Mapping the human genome requires a set of genetic markers. DNA polymorphism serves as a genetic marker for its own location in the chromosome; thus, they are convenient for analysis and are often used as in molecular genetic studies.

Author: Yamin Liu
Publisher: BoD – Books on Demand
ISBN: 1789842018
Category : Medical
Languages : en
Pages : 166

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Book Description
Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms.

Author: R.L. Phillips
Publisher: Springer Science & Business Media
ISBN: 9401598150
Category : Science
Languages : en
Pages : 508

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Book Description
With the new techniques described in this volume, a new gene can be placed on the linkage map within only a few days. Leading researchers have updated the earlier edition to include the latest versions of DNA-based marker maps for a variety of important crops.

Author: Gustavo Caetano-Anollés
Publisher: Wiley-Liss
ISBN:
Category : Law
Languages : en
Pages : 392

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Book Description
In the four decades since the discovery of DNA, molecular genetics and biotechnology have undergone a revolution in the research and application of genetic testing techniques. As a result, these fields have witnessed an explosion of both information and controversy, and the focus of public awareness of the significance of molecular biotechnology in everyday life has leaped from journal abstracts to front-page news. Molecular biotechnology provides important tools for the identification of specific nucleic acid sequences, some of them linked to important traits such as those conferring resistance to disease. Such DNA markers are used commonly in genetic research and in other applications, such as DNA fingerprinting. Researchers can use DNA markers to follow individual traits in different environments and hosts, increasing our understanding of the constitution, diversity, and evolution of genetic material. DNA Markers: Protocols, Applications, and Overviews offers valuable new information on this rapidly growing field. This compendium of research highlights the most recently discovered DNA markers and their application to the analyses of genomes of low and high complexity, with a focus on recently developed DNA marker systems as tools for DNA fingerprinting, genome analysis, molecular systematics, taxonomy, and phylogenetic analysis. The Protocols section of the book contains detailed, step-by-step instructions on how to perform selected DNA marker experiments, providing a useful laboratory tool. Subjects covered by top specialists include: Designed as a bench-top reference for the laboratory as well as a complete guide to the latest research, DNA Markers: Protocols, Applications, and Overviews is a vital resource for both novices and experienced practitioners involved in research in molecular genetics or biotechnology. A global overview of DNA markers * Molecular hybridization * RAPD, AP-PCR, DAF and AFLP analysis * Microbial Genomic fingerprinting * Simple sequence repeat DNA markers * Genetic BIT analysis * Differential display of RNA * The status of DNA fingerprinting: population databases * Arbitrarily amplified DNA in ecology and evolution

Author: R.J. Trent
Publisher: Elsevier
ISBN: 0080454380
Category : Science
Languages : en
Pages : 319

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Book Description
Molecular medicine is the application of gene or DNA based knowledge to the modern practice of medicine. This book provides contemporary insights into how the genetic revolution is influencing medical thinking and practice on a broad front including clinical medicine, innovative therapies and forensic medicine. Extensively revised just after the completion of the Human Genome Project, it provides the latest in molecular medicine developments The only book in Molecular Medicine that has undergone three editions Current practice as well as future developments identified Extensive tables, well presented figures - resources for further understanding

Author: Mamta Singh
Publisher: LAP Lambert Academic Publishing
ISBN: 9783844334838
Category :
Languages : en
Pages : 160

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Book Description
Recent developments in DNA marker technologies have made it possible to uncover a large number of genetic polymorphisms at the DNA sequence level, and to use them as markers for evaluation of the genetic basis for the observed phenotypic variability. The molecular markers possess unique genetic properties and methodological advantages that make them more useful and amenable for genetic analysis compared to other genetic markers The commonly used techniques are allozyme analysis, RFLP, RAPD, AFLP, microsatellite typing, SNP and EST markers, etc. In present book, three DNA markers i.e. microsatellite, mitochondrial DNA and SNPs, along with their application in assessments of genetic variability and inbreeding, parentage assignment, species and strain identification, hybridization and marker assisted selection are discussed in detail.

Author: Mahmut Çalışkan
Publisher: BoD – Books on Demand
ISBN: 1789858917
Category : Medical
Languages : en
Pages : 149

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Book Description
The book in your hands presents chapters revealing the magnitude of genetic polymorphisms that exist in different kinds of living beings. Natural populations contain a considerable amount of genetic change, which provides a genomic flexibility that can be used as a raw material for adaptation to changing environmental conditions. The analysis of genetic polymorphisms provides information about DNA sequence changes at a given locus. The increasing availability of PCR-based molecular markers allows for the detailed analyses and the detection of genetic changes influencing some important traits. The purpose of this book is to provide a glimpse into the dynamic process of genetic polymorphisms by presenting the thoughts of scientists engaged in the generation of new ideas and techniques employed for the assessment of genetic polymorphisms. The book should prove useful to students, researchers and experts in the area of molecular genetics.

Author: Bruno W.S. Sobral
Publisher: Springer Science & Business Media
ISBN: 1461598559
Category : Science
Languages : en
Pages : 352

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Book Description
The impact of molecular genetics on plant breeding and, consequently, agri culture, is potentially enonnous. Understanding and directing this potential im pact is crucial because of the urgent issues that we face concerning sustainable agriculture for a growing world population as well as conservation of the world's rapidly dwindling plant genetic resources. This book is largely devoted to the applications of genetic markers that have been developed by the application of molecular genetics to practical problems. These are known as DNA markers. They have gained a certain notoriety in foren sics, but can be used in a variety of practical situations. We are going through a period of accelerated breakthroughs in molecular ge netics. Therefore, the authors of each chapter were encouraged to speculate about both current bottlenecks and the future of their subfields of research. We can cer tainly apply molecular genetic tools and approaches to help resolve crucial ge netic resource problems that face humanity. However, little has been discussed with respect to when or how we should use such tools, nor to who specifically should use them; therefore, social and economic analyses are important in the planning stages of projects that are aimed at practical results.

Author: J. C. Avise
Publisher: Springer Science & Business Media
ISBN: 9780412037719
Category : Medical
Languages : en
Pages : 534

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Book Description
Molecular approaches have opened new windows on a host of ecological and evolutionary disciplines, ranging from population genetics and behavioral ecology to conservation biology and systematics. Molecular Markers, Natural History and Evolution summarizes the multi-faceted discoveries about organisms in nature that have stemmed from analyses of genetic markers provided by polymorphic proteins and DNAs. The first part of the book introduces rationales for the use of molecular markers, provides a history of molecular phylogenetics, and describes a wide variety of laboratory methods and interpretative tools in the field. The second and major portion of the book provides a cornucopia of biological applications for molecular markers, organized along a scale from micro-evolutionary topics (such as forensics, parentage, kinship, population structure, and intra-specific phylogeny) to macro-evolutionary themes (including species relationships and the deeper phylogenetic structure in the tree of life). Unlike most prior books in molecular evolution, the focus is on organismal natural history and evolution, with the macromolecules being the means rather than the ends of scientific inquiry. Written as an intellectual stimulus for the advanced undergraduate, graduate student, or the practicing biologist desiring a wellspring of research ideas at the interface of molecular and organismal biology, this book presents material in a manner that is both technically straightforward, yet rich with concepts and with empirical examples from the world of nature.

Author: Narasimha Reddy Parine
Publisher: BoD – Books on Demand
ISBN: 9535135155
Category : Medical
Languages : en
Pages : 282

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Book Description
The objective of this Genetic Polymorphisms book is to rehighlight and provide few updates on the role of genetic polymorphisms in medicine and agriculture, which void emerging opinion on "full death" of genetic polymorphisms as useful genetic markers. Chapters presented here demonstrate the future benefit of SNPs in many genetic studies as well as prognosis disease and diagnosis.