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Author: V.E. Andreucci Publisher: Springer Science & Business Media ISBN: 1461320674 Category : Medical Languages : en Pages : 609
Book Description
The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana", the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill". But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice.
Author: V.E. Andreucci Publisher: Springer Science & Business Media ISBN: 1461320674 Category : Medical Languages : en Pages : 609
Book Description
The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana", the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill". But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice.
Author: Donald W. Seldin Publisher: Academic Press ISBN: 008053046X Category : Science Languages : en Pages : 685
Book Description
The only comprehensive work to cover all aspects of diuretic agents, the book discusses the pharmacology and toxicology of diuretic agents as well as the physiological effects. Experts in the field present the principles and experimental approaches for the study of interactions between pharmacologic compounds in relation to specific target organs. Diuretic Agents contains information on the mechanisms of action and application of diuretics, and details FDA regulations and pharmaceutical industry guidelines. Written by experts in the field Covers all aspects of diuretic agents Includes information on the mechanisms of action and application of diuretics
Author: Jules B. Puschett Publisher: Elsevier Publishing Company ISBN: Category : Medical Languages : en Pages : 832
Book Description
Diuretics II addresses every aspect of diuretics from basic pharmacology to clinical and experimental applications. The expertise of international scientists and doctors in fields such as chemistry, biochemistry, physiology, pharmacology, clinical and investigative medicine give you a thorough and up-to-date presentation of diuretics and their effects on the kidneys and other organ systems. This volume covers new and investigational diuretic agents, transport physiology and the molecular basis of diuretic action, the atrial natriuretic factor, along with drug-induced renal disease and metabolic abnormalities as they relate to diuretic administration. Piretanide, Tripamide, Cicletanine, Torasemide, Furosemide are among a few of the diuretics selected for review in this thorough investigation on diuretics designed specifically for all who employ, investigate and develop diuretic drugs. NEW YORK
Author: Lars Wouters Publisher: ISBN: 9781628082562 Category : Medical Languages : en Pages : 154
Book Description
Diuretics are drugs that increase urine water and salt excretion, and for that reason they are widely used for treating arterial hypertension, and edematous states such as decompensated cardiac failure, cirrhosis, and nephropathy. In this book, the authors present current research in the study of the pharmacology, therapeutic uses and adverse side effects of diuretics. Topics include the aquaretic effect of vasopressin V2 receptor antagonists; basic principles of diuretic therapy; predictors to blood pressure response and the adverse side effects of thiazide diuretics; diuretic therapy in heart failure; diuretics as antiepileptics; and potent diuretics and potassium sparing agents.
Author: Neil N. Turner Publisher: Oxford University Press ISBN: 0191017655 Category : Medical Languages : en Pages : 3045
Book Description
This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence. This print edition of The Oxford Textbook of Clinical Nephrology comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.
Author: Lars Wouters Publisher: Nova Science Pub Incorporated ISBN: 9781628082548 Category : Medical Languages : en Pages : 143
Book Description
Diuretics are drugs that increase urine water and salt excretion, and for that reason they are widely used for treating arterial hypertension, and edematous states such as decompensated cardiac failure, cirrhosis, and nephropathy. In this book, the authors present current research in the study of the pharmacology, therapeutic uses and adverse side effects of diuretics. Topics include the aquaretic effect of vasopressin V2 receptor antagonists; basic principles of diuretic therapy; predictors to blood pressure response and the adverse side effects of thiazide diuretics; diuretic therapy in heart failure; diuretics as antiepileptics; and potent diuretics and potassium sparing agents.
Author: Lars Wouters Publisher: ISBN: 9781628082562 Category : Medical Languages : en Pages : 154
Book Description
Diuretics are drugs that increase urine water and salt excretion, and for that reason they are widely used for treating arterial hypertension, and edematous states such as decompensated cardiac failure, cirrhosis, and nephropathy. In this book, the authors present current research in the study of the pharmacology, therapeutic uses and adverse side effects of diuretics. Topics include the aquaretic effect of vasopressin V2 receptor antagonists; basic principles of diuretic therapy; predictors to blood pressure response and the adverse side effects of thiazide diuretics; diuretic therapy in heart failure; diuretics as antiepileptics; and potent diuretics and potassium sparing agents.
Author: V.E. Andreucci
Author: V.E. Andreucci
Author: Donald W. Seldin
Author: Jules B. Puschett
Author: Lars Wouters
Author: W. T. Abraham
Author: John H. Dirks
Author: Neil N. Turner
Author: Jules B. Puschett
Author: Lars Wouters
Author: Lars Wouters