Dissecting Synaptic Mechanisms of Sound Encoding in the Mouse Cochlea PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Dissecting Synaptic Mechanisms of Sound Encoding in the Mouse Cochlea PDF full book. Access full book title Dissecting Synaptic Mechanisms of Sound Encoding in the Mouse Cochlea by Philippe Jean. Download full books in PDF and EPUB format.
Author: Philippe Jean Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
Cochlear inner hair cells (IHCs) are the genuine sensory receptors that translate sound-borne cochlear vibrations into neuronal signals via ribbon synapses with the spiral ganglion neurons (SGNs). The precise mechanisms of these ribbon synapses, the first relay of the auditory pathway, are still not fully resolved. Sound intensity coding over a wide dynamic range is thought to be fractionated through the SGNs presenting distinct firing characteristics. One hypothesis is that much of this diversity reflects the presynaptic heterogeneity observed among the active zones (AZs) of IHCs. There, a...
Author: Philippe Jean Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
Cochlear inner hair cells (IHCs) are the genuine sensory receptors that translate sound-borne cochlear vibrations into neuronal signals via ribbon synapses with the spiral ganglion neurons (SGNs). The precise mechanisms of these ribbon synapses, the first relay of the auditory pathway, are still not fully resolved. Sound intensity coding over a wide dynamic range is thought to be fractionated through the SGNs presenting distinct firing characteristics. One hypothesis is that much of this diversity reflects the presynaptic heterogeneity observed among the active zones (AZs) of IHCs. There, a...
Author: Publisher: ISBN: Category : Languages : en Pages : 210
Book Description
Afferent synapses between inner hair cells (IHCs) and spiral ganglion neurons in the cochlea translate sound information into a discrete spike code, providing us the opportunity to directly observe the output of the cochlea. The availability of mutant strains with genetic hearing impairment makes the mouse a valuable species to investigate the molecular mechanisms of cochlear function. In this thesis, mouse was used as a model species to study cochlear sound encoding by recording single unit activities from auditory nerve fibers (ANFs) in vivo. First, developmental changes of ANF responses ...
Author: Maike Pelgrim Publisher: ISBN: Category : Languages : en Pages :
Book Description
Auditory neuropathy and auditory synaptopathy are hearing disorders with normal outer hair cell function and cochlear amplification, but an impairment in the function of inner hair cells, their ribbon synapses, or in the spiral ganglion neurons and neurons of the auditory pathway, respectively. In order to better understand the disease mechanisms, we analyzed central sound encoding in the inferior colliculus, the main auditory nucleus of the midbrain. We performed electrophysiological in vivo single unit recordings from the central nucleus of the inferior colliculus in three strains of muta...
Author: Tzu-Lun Wang Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
Sound intensity is encoded as action potential firing rates by spiral ganglion neurons. These neurons show different rate-level functions with different auditory thresholds, and are thought to collectively encode the large dynamic range of the auditory stimuli. Hair cell ribbon synapses drive the action potential firing in spiral ganglion neurons through release of glutamate that is triggered by voltage-gated Ca2+ channels. Therefore, the investigation of presynaptic Ca2+ signaling and its relationship to synaptic ribbons might help to explain how inner hair cells (IHCs) decompose auditory ...
Author: Gulnara Yamanbaeva Publisher: ISBN: Category : Languages : en Pages :
Book Description
Auditory tasks like sound localization or speech recognition require reliable and temporally precise neuronal sound encoding. The neuronal code must accurately preserve signal properties such as intensity and timing. Electrophysiological recordings from single spiral ganglion neuron provide a detailed picture of how auditory sensory information is encoded. Analysis of the response pattern of the cochlear nucleus cells after receiving sensory information encoded at peripheral synapses gives insight into the auditory systems primary processing. Investigation of the response patterns of spiral...
Author: Publisher: ISBN: Category : Languages : en Pages : 154
Book Description
A key stage in auditory encoding is the transformation of the analog and continuous electrical signal at inner hair cells (IHCs) into the discrete spike timings in auditory nerve fibers (ANFs). In this work, using modeling, we investigated the biophysical specializations of the IHC ribbon synapse, which support this transcoding of the auditory signal. First, in combination with experiments, we studied the coupling of the ANF postsynaptic bouton to its action potential generator. We found that ANFs encode with submillisecond precision the timings of neurotransmitter release from IHCs. Then, ...
Author: Alain Dabdoub Publisher: Springer ISBN: 1493930311 Category : Medical Languages : en Pages : 300
Book Description
This volume details the essential role of the spiral ganglion neurons. The volume elucidates and characterizes their development, their environment, their electrophysiological characteristics, their connectivity to their targets in the inner ear and the brain, and discusses the potential for their regeneration. A comprehensive review about the spiral ganglion neurons is important for researchers not only in the inner ear field but also in development, neuroscience, biophysics as well as neural networks researchers. The chapters are authored by leading researchers in the field.
Author: Philippe Jean
Author: Philippe Jean
Author: 
Author: Maike Pelgrim
Author: Tzu-Lun Wang
Author: Jane Jia Feng
Author: Sean Joseph Slee
Author: Gulnara Yamanbaeva
Author: 
Author: Lin-Chien Huang
Author: Alain Dabdoub