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Author: Christa E. Flück Publisher: Karger Medical and Scientific Publishers ISBN: 3805585802 Category : Medical Languages : en Pages : 173
Book Description
Substantial further advances in our understanding of adrenal development, steroid biosynthesis and adrenocortical disorders necessitate another look at this small but complex organ. In this volume, leaders in the fields of adrenal development, biochemistry and genetics review the most recent findings from bench and bedside research. New aspects of adrenal development and zonation and the novel 'backdoor' pathway to androgen synthesis are discussed. P450 oxidoreductase deficiency (a newly described form of congenital adrenal hyperplasia) and long-term outcome of prenatal treatment of 21-hydroxylase deficiency are examined. An update on ACTH resistance and adrenal Cushing's syndrome is provided. Finally, the role of adrenal steroidogenesis in arterial hypertension and fetal programming of adrenal androgen excess as a possible explanation for polycystic ovary syndrome in later life are analyzed. This book will be of great interest to pediatric, adult and reproductive endocrinologists, clinical geneticists, developmental biologists and basic scientists working in the fields of endocrinology and steroidogenesis.
Author: Christa E. Flück Publisher: Karger Medical and Scientific Publishers ISBN: 3805585802 Category : Medical Languages : en Pages : 173
Book Description
Substantial further advances in our understanding of adrenal development, steroid biosynthesis and adrenocortical disorders necessitate another look at this small but complex organ. In this volume, leaders in the fields of adrenal development, biochemistry and genetics review the most recent findings from bench and bedside research. New aspects of adrenal development and zonation and the novel 'backdoor' pathway to androgen synthesis are discussed. P450 oxidoreductase deficiency (a newly described form of congenital adrenal hyperplasia) and long-term outcome of prenatal treatment of 21-hydroxylase deficiency are examined. An update on ACTH resistance and adrenal Cushing's syndrome is provided. Finally, the role of adrenal steroidogenesis in arterial hypertension and fetal programming of adrenal androgen excess as a possible explanation for polycystic ovary syndrome in later life are analyzed. This book will be of great interest to pediatric, adult and reproductive endocrinologists, clinical geneticists, developmental biologists and basic scientists working in the fields of endocrinology and steroidogenesis.
Author: C. E. Flück Publisher: ISBN: Category : Languages : en Pages :
Book Description
Substantial further advances in our understanding of adrenal development, steroid biosynthesis and adrenocortical disorders necessitate another look at this small but complex organ. In this volume, leaders in the fields of adrenal development, biochemistry and genetics review the most recent findings from bench and bedside research. New aspects of adrenal development and zonation and the novel 'backdoor' pathway to androgen synthesis are discussed. P450 oxidoreductase deficiency (a newly described form of congenital adrenal hyperplasia) and long-term outcome of prenatal treatment of 21-hydroxylase deficiency are examined. An update on ACTH resistance and adrenal Cushing's syndrome is provided. Finally, the role of adrenal steroidogenesis in arterial hypertension and fetal programming of adrenal androgen excess as a possible explanation for polycystic ovary syndrome in later life are analyzed. This book will be of great interest to pediatric, adult and reproductive endocrinologists, clinical geneticists, developmental biologists and basic scientists working in the fields of endocrinology and steroidogenesis.
Author: Pierre Val Publisher: Frontiers Media SA ISBN: 2889199193 Category : Adrenal cortex Languages : en Pages : 91
Book Description
The adrenal gland plays essential roles in the control of body homeostasis, stress and immune responses. The adrenal cortex represents up to 90% of the gland and is specialised in the production of mineralocorticoids, glucocorticoids and adrenal androgens. This production is tightly coordinated and results from a unique zonal organisation. Although our knowledge of the molecular mechanisms controlling adrenal steroidogenesis is quite extensive, for decades, the mechanisms of adrenal cortex development, cellular homeostasis and renewal have remained elusive. The advent of new high-throughput technologies and sophisticated genetic approaches has brought tremendous progress in our understanding of how the adrenal cortex achieves and maintains its particular organisation. The aim of this Frontiers in Endocrinology Topic is to provide readers with a snapshot of our current knowledge on adrenal physiology and how deregulations of these processes result in adrenal diseases. This includes but is not limited to, basic research on adrenal development, cell lineage identification, progenitor cells, tissue renewal, control of differentiation and zonation and clinical research on the identification of disease-related genes.
Author: I. A. Hughes Publisher: Karger Medical and Scientific Publishers ISBN: 3805570155 Category : Medical Languages : en Pages : 186
Book Description
Adrenal disease in children poses an immensely difficult diagnostic and management problem for the paediatrician in view of the large number of rare pathologies that may present in this way. This volume brings together the expertise of the acknowledged leaders in specific adrenal disorders to provide a readily accessible text that combines a detailed description of the molecular origins of these diseases, as they are currently understood, with a unique account of the clinical features and therapeutic options. Beginning with disorders that primarily affect adrenal development and progressing towards the defects that interfere with steroid production, the reader gains considerable insight into the normal physiology of the adrenal cortex particularly as revealed by clinical disorders. The major contributions of modern biochemistry and molecular genetics in our current understanding are visible throughout, providing a unique overview of adrenocortical biology. This book is of great interest to general pediatricians, paediatric endocrinologists, adult endocrinologists, clinical geneticists and basic scientists working in areas such as developmental biology and molecular steroidogenesis.
Author: Lucia Ghizzoni Publisher: Karger Medical and Scientific Publishers ISBN: 380559643X Category : Medical Languages : en Pages : 225
Book Description
Written by experts and specialized investigators, this book presents a detailed overview of the recent progress in our understanding of the adrenal cortex and its pivotal roles in homeostasis. Genes, molecules and cell compartments directly or indirectly involved in the complex steroidogenesis pathway as well as the resulting end-hormones glucocorticoids, mineralocorticoids and androgens are analyzed. Furthermore, the defects of the genes responsible both for common and rare adrenal disorders are presented. The interactions of the adrenal cortices with the adrenal medulla and their importance in the integration of adrenocortical and adrenomedullary function are discussed. The complex molecular pathophysiology of congenital adrenal hyperplasia is presented; long-term effects of the disorder and the still controversial antenatal therapy are examined. Finally, expert review chapters discuss autoimmune Addison disease and the adrenoleukodystrophy/adrenomyeloneuropathy syndrome. Presenting novel research findings in adrenal gland physiology and pathophysiology, this book is a useful tool not only for pediatric endocrinologists, but also for clinicians and researchers studying human development, organogenesis, mitochondrial biology, nuclear receptors, stress biology and pharmacology.
Author: Yewei Xing Publisher: Elsevier Inc. Chapters ISBN: 0128072776 Category : Medical Languages : en Pages : 62
Book Description
The adrenal glands comprise two distinct endocrine organs: the inner medulla and the outer cortex. The inner medulla is made up of neuroectodermal cells derived from the neural crest and produces the catecholamine hormones norepinephrine and epinephrine, which are crucial for stress responses. The outer cortex is derived from the mesoderm and synthesizes steroid hormones that are essential to maintain fluid and electrolyte balance, modulate intermediary metabolism and regulate inflammatory processes. Steroidogenesis in the adrenal cortex is mainly regulated by trophic hormones controlled by the hypothalamus–pituitary endocrine axes. Adrenal organogenesis and development of adult steroidogenesis are carefully orchestrated by action of a number of gene products. Although the pattern of development differs somewhat in diverse primates, the same genes appear to regulate the basic developmental program in all mammalian species. Most basic laboratory research is done in mice, in which prenatal development occurs within a compressed period of approximately 19 days and in which adrenals at birth are considerably less developed than in their human counterparts. This chapter describes the contributions of genes responsible for the proper development of the adrenal cortex, as well as how an understanding of adrenal gland disease provides novel fundamental insights into the regulation of adrenal development and steroidogenesis.
Author: Andrew N. Margioris Publisher: Springer Science & Business Media ISBN: 1592591019 Category : Medical Languages : en Pages : 420
Book Description
In Adrenal Disorders, a panel of distinguished physicians and researchers select the most relevant new findings and integrate them into the existing body of clinical knowledge on adrenal pathologies. The book includes important reviews of disturbances in cortisol homeostasis, and new concepts regarding adrenal tumors and hereditary adrenal diseases. Also discussed are mineralocorticoids and the syndromes of mineralocortoid excess and aldosterone synthase deficiency. Authoritative and insightful, Adrenal Disorders provides physicians and scientists with a comprehensive, state-of-the-art practical guide to the devastating diseases of the adrenals that are so often difficult to diagnose and treat.
Author: Alice C. Levine Publisher: Humana Press ISBN: 3319624709 Category : Medical Languages : en Pages : 340
Book Description
This practical resource provides the latest evidence, management strategies and recommendations for the treatment of disorders of the adrenal glands, including related physiology, genetics and pharmacology. This book is divided into three thematic sections. The first covers adrenal physiology, presenting adrenal zonation and development, the regulation of steroidogenesis, and the pharmacology of glucocortisoids. Part two discusses the genetics and pathophysiology of a number of adrenal disorders, including autoimmune Addison’s disease, congenital adrenal hyperplasia, primary aldosteronism, adrenocortical tumors and hyperplasias, and pheochromocytomas and paragangliomas. The final section presents the latest diagnostic and management strategies for these disorders, addressing adrenal insufficiency, adrenal Cushing’s Syndrome and aldosteronism, among others. Over the past twenty years, our understanding of disorders of the adrenal glands has been altered and deepened. Providing a much-needed update to the literature, Adrenal Disorders: Physiology, Pathophysiology and Treatment will be an important resource for both academic and clinical endocrinologists working with the adrenal glands and managing patients with adrenal disorders.
Author: David C. Anderson Publisher: Butterworth-Heinemann ISBN: 1483192113 Category : Medical Languages : en Pages : 310
Book Description
Adrenal Cortex presents a critical review of functional and structural zonation of the cortex. It discusses the regulation of adrenocortical function by control of growth and structure. It also addresses the adrenal cortex in the fetus and neonate. It demonstrates the cellular mechanisms involved in the acute and chronic actions of ACTH. Some of the topics covered in the book are the molecular structures of mineralocorticoid and glucocorticoid receptors; description of adrenarche and adrenal hirsutism; types of congenital enzymatic defects of the adrenal; aetiology and management of Cushing’s syndrome; and the relationship between adrenal cortex and hypertension. The description and characteristics of adrenocortical dysfunction are fully covered. The interactions between the adrenal cortex and medulla are extensively discussed. An in-depth analysis of the pharmacokinetics of natural and synthetic glucocorticoids is provided. A study of the regulation of normal steroidogenesis by adrenocortical structure is well presented. A chapter is devoted to possible role of vascular system in neural stimulations. The book can provide useful information to neurologists, doctors, students, and researchers.
Author: Publisher: Academic Press ISBN: 012391454X Category : Science Languages : en Pages : 359
Book Description
This new volume of Current Topics in Developmental Biology covers endocrine gland development and disease, and with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as sex determination & gonadogenesis, hypothalamus, paraythyroid and placenta. Covers the area of endocrine gland development and disease International board of authors Provides a comprehensive set of reviews covering such topics as sex determination & gonadogenesis and the adrenal, thyroid and pineal glands.
Author: Christa E. Flück
Author: Christa E. Flück
Author: C. E. Flück
Author: Pierre Val
Author: I. A. Hughes
Author: Lucia Ghizzoni
Author: Yewei Xing
Author: Andrew N. Margioris
Author: Alice C. Levine
Author: David C. Anderson
Author: