Author: Hermann SenatorPublisher:
ISBN:
Category : Hemorrhagic diseases
Languages : en
Pages : 858
Book Description
Diseases of the Kidneys and of the Spleen, Hemorrhagic Diseases
Author: Hermann SenatorPublisher:
ISBN:
Category : Hemorrhagic diseases
Languages : en
Pages : 858
Book Description
The American Journal of the Medical Sciences
Author: Cystogenesis
Author: Jong Hoon ParkPublisher: Springer
ISBN: 9811020418
Category : Medical
Languages : en
Pages : 128
Book Description
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Rickettsial Diseases
Author: Didier RaoultPublisher: CRC Press
ISBN: 142001997X
Category : Medical
Languages : en
Pages : 400
Book Description
The only available reference to comprehensively discuss the common and unusual types of rickettsiosis in over twenty years, this book will offer the reader a full review on the bacteriology, transmission, and pathophysiology of these conditions. Written from experts in the field from Europe, USA, Africa, and Asia, specialists analyze specific patho
Ferri's Clinical Advisor 2020 E-Book
Author: Fred F. FerriPublisher: Elsevier Health Sciences
ISBN: 0323679773
Category : Medical
Languages : en
Pages : 7615
Book Description
Significantly updated with the latest developments in diagnosis and treatment recommendations, Ferri's Clinical Advisor 2020 features the popular "5 books in 1" format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all reviewed by experts in key clinical fields. Updated algorithms, along with hundreds of new figures, tables, and boxes, ensure that you stay current with today's medical practice. - Contains significant updates throughout, covering all aspects of current diagnosis and treatment. - Features 27 all-new topics including chronic traumatic encephalopathy, medical marijuana, acute respiratory failure, gallbladder carcinoma, shift work disorder, radial tunnel syndrome, fertility preservation in women, fallopian tube cancer, primary chest wall cancer, large-bowel obstruction, inguinal hernia, and bundle branch block, among others. - Includes a new appendix covering Physician Quality Reporting System (PQRS) Measures. - Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. - Patient Teaching Guides for many of the diseases and disorders are included, most available in both English and Spanish versions, which can be downloaded and printed for patients.
The Journal of the Kansas Medical Society
Author: Kansas Medical SocietyPublisher:
ISBN:
Category : Medicine
Languages : en
Pages : 426
Book Description
Canadian Journal of Medicine and Surgery
Author: The New England Journal of Medicine
Author: The Journal of the Michigan State Medical Society
Author: The Saint-Chopra Guide to Inpatient Medicine
Author: Sanjay SaintPublisher: Oxford University Press, USA
ISBN: 0190862807
Category : Medical
Languages : en
Pages : 609
Book Description
Preceded by: Clinical clerkship in inpatient medicine / Sanjay Saint. 3rd ed. c2010.