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Author: Walter Karcher Publisher: Cambridge University Press ISBN: 9780521303828 Category : Medical Languages : en Pages : 296
Book Description
A systematic survey of the dibenzanthracenes and of their chemical, physiochemical, and biological properties, this book treats the nomenclature, the chemical and physical properties, and the synthesis and preparation of the five principal isomers of the dibenzanthracene series: dibenz (a, h), dibenz (a, c), dibenz (a, j), anthracene, benzo(a)naphthacene, and pentacene. Other chapters are devoted to their occurrence and analysis in the environment, in industrial processes and effluents, and in foodstuffs. T second part addresses their biological activity and reviews the metabolism, cellular interactions, toxicology, mutagenicity, and carcinogenicity of the dibenzanthracenes. The final chapter is devoted to structure-activity relationships in this class of the aromatic compounds.
Author: Walter Karcher Publisher: Cambridge University Press ISBN: 9780521303828 Category : Medical Languages : en Pages : 296
Book Description
A systematic survey of the dibenzanthracenes and of their chemical, physiochemical, and biological properties, this book treats the nomenclature, the chemical and physical properties, and the synthesis and preparation of the five principal isomers of the dibenzanthracene series: dibenz (a, h), dibenz (a, c), dibenz (a, j), anthracene, benzo(a)naphthacene, and pentacene. Other chapters are devoted to their occurrence and analysis in the environment, in industrial processes and effluents, and in foodstuffs. T second part addresses their biological activity and reviews the metabolism, cellular interactions, toxicology, mutagenicity, and carcinogenicity of the dibenzanthracenes. The final chapter is devoted to structure-activity relationships in this class of the aromatic compounds.
Author: P. Michael Conn Publisher: Academic Press ISBN: 0123948312 Category : Medical Languages : en Pages : 479
Book Description
This volume explores some of the most exciting recent advances in basic research on animal models of molecular pathology. - This series provides a forum for discussion of new discoveries, approaches, and ideas - Contributions from leading scholars and industry experts - Reference guide for researchers involved in molecular biology and related fields
Author: G. Grimmer Publisher: CRC Press ISBN: 1351080202 Category : Science Languages : en Pages : 272
Book Description
The present survey comprises today‘s knowledge of environmental pollution in particular of the atmosphere by PAH and of the biological effects of this class of substance, putting special emphasis on their carcinogenic activity. The research data and conclusions derived therefrom are meant to assist the government of the Federal Republic of Germany in determining an air quality standard.
Author: Trevor M. Penning Publisher: Springer Science & Business Media ISBN: 1617379956 Category : Medical Languages : en Pages : 447
Book Description
This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Author: Joseph G. Cory Publisher: Springer Science & Business Media ISBN: 1475795645 Category : Medical Languages : en Pages : 266
Book Description
In anticipation of the opening of the H. Lee Moffitt Cancer Center and Research lnstitut~ on the campus of the University of South Florida, an international symposium, "The First Annual H. Lee Moffitt Symposium on Cancer Biology and Therapeutics" was held in Tampa, Florida on January 20-22, 1986. In this first symposium we decided to present a broad-based series of topics dealing with the major issues in the field of cancer. These topics ranged from the biochemistry of the cancer cell to the design of antineoplastic agents, through tumor cell heterogeneity, treatment of ltuman neoplasms to immunological aspects of cancer biology and tr~atment. The speakers chosen represented individuals of international acclaim who are very active in the area of cancer research and treatment. The symposium brought together scien tists/physicians from six nations including Austria, Canada, France, Hungary, West Germany, and of course, the United States. The congeniality of the participants promoted the friendly exchange of knowledge which, it is hoped, will greatly hasten the time when successful management of human cancer will become routine. Future symposia in this series will be highly focused and will deal with a single facet of this vast field of cancer research and treatment. Joseph G. Cory, Editor Andor Szentivanyi, Editor University of South Florida, 1986 V ACKNOWLEDGMENTS This volume presents the Proceedings of the H. Lee Moffitt International Syn~osium on Cancer Biology and Therapeutics which was held in Tampa, Florida on January 20, 21, and 22, 1986.
Author: Miral Dizdaroglu Publisher: Royal Society of Chemistry ISBN: 1839162562 Category : Science Languages : en Pages : 509
Book Description
The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.
Author: Damia Barcelo Publisher: Elsevier ISBN: 0080466672 Category : Science Languages : en Pages : 349
Book Description
Volume 1 of the Sustainable Management of Sediment Resources mini-series is the first attempt to fill many of these gaps in knowledge and also in practice. The volume includes sections on: - Sampling - Characterization of contaminants in sediments being bioavailability the main issue - Chemical analysis - Biological analysis - Effect directed analysis and toxicity - Identification evaluation - Benthos sediment quality assessment - Modelling of pollutant fate and behaviour - Sediment quality guidelines This first volume is applicable to a wide audience, from students at the graduate level, to experienced researchers and laboratory personnel in academia, industry and government. This volume also available as part of a 4-volume set, ISBN 0444519599. Discount price for set purchase. - A broad overview on sediment quality and impact assessment of pollutants - Suitable for both newcomers to the field of sediment treatment and specialists alike - Outlines practical examples of methods used in sediment quality analysis
Author: Walter Karcher
Author: Walter Karcher
Author: 
Author: P. Michael Conn
Author: G. Grimmer
Author: Trevor M. Penning
Author: 
Author: Joseph G. Cory
Author: Miral Dizdaroglu
Author: United States. Surgeon General's Advisory Committee on Smoking and Health
Author: Damia Barcelo