Developmental Human Behavioral Epigenetics PDF Download

Author: Livio Provenzi
Publisher: Academic Press
ISBN: 0128192631
Category : Science
Languages : en
Pages : 190

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Book Description
Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions, Volume 23, a new volume in the Translational Epigenetics series, offers the first systematic account of theoretical G79 frameworks, methodological approaches, findings, and future directions in the field of human behavioral epigenetics. Featuring contributions from leading scientists and international researchers, this book provides a comprehensive overview of human behavioral epigenetics, with a close examination of evidence gathered to-date from animal models, challenges of human-based research and clinical translation, pathways towards drug discovery, and next steps in research. Areas of focus include prenatal stress exposures, preterm behavioral epigenetics, intergenerational exposures, trauma and neglect, socio-economic conditions, maternal caregiving and attachment, study design, and epigenetics and psychotherapy. Enables more effective study design and methods application in behavioral epigenetics research across human and animal models Examines findings in human behavioral epigenetics to-date Features contributions from leading international researchers in behavioral epigenetics

Author: David Scott Moore
Publisher: Oxford University Press, USA
ISBN: 0199922349
Category : Medical
Languages : en
Pages : 321

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Book Description
An accessible introduction to behavioral epigenetics, The Developing Genome explores how experiences influence genetic activity. We develop as we do not because of the genes we have, but because of what our genes do. The Developing Genome explains this new discipline and its revolutionary implications, changing how we understand development and evolution.

Author: David S. Moore
Publisher: Oxford University Press
ISBN: 0190613769
Category : Psychology
Languages : en
Pages : 320

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Book Description
Why do we grow up to look, act, and feel as we do? Through most of the twentieth century, scientists and laypeople answered this question by referring to two factors alone: our experiences and our genes. But recent discoveries about how genes work have revealed a new way to understand the developmental origins of our characteristics. These discoveries have emerged from the new science of behavioral epigenetics--and just as the whole world has now heard of DNA, "epigenetics" will be a household word in the near future. Behavioral epigenetics is important because it explains how our experiences get under our skin and influence the activity of our genes. Because of breakthroughs in this field, we now know that the genes we're born with don't determine if we'll end up easily stressed, likely to fall ill with cancer, or possessed of a powerful intellect. Instead, what matters is what our genes do. And because research in behavioral epigenetics has shown that our experiences influence how our genes function, this work has changed how scientists think about nature, nurture, and human development. Diets, environmental toxins, parenting styles, and other environmental factors all influence genetic activity through epigenetic mechanisms; this discovery has the potential to alter how doctors treat diseases, and to change how mental health professionals treat conditions from schizophrenia to post-traumatic stress disorder. These advances could also force a reworking of the theory of evolution that dominated twentieth-century biology, and even change how we think about human nature itself. In spite of the importance of this research, behavioral epigenetics is still relatively unknown to non-biologists. The Developing Genome is an introduction to this exciting new discipline; it will allow readers without a background in biology to learn about this work and its revolutionary implications.

Author: Philip David Zelazo
Publisher: Oxford University Press
ISBN: 0199958459
Category : Medical
Languages : en
Pages : 1049

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Book Description
This handbook provides a comprehensive survey of what is now known about psychological development, from birth to biological maturity, and it highlights how cultural, social, cognitive, neural, and molecular processes work together to yield human behavior and changes in human behavior.

Author: Gilbert Gottlieb
Publisher: Psychology Press
ISBN: 1135639329
Category : Psychology
Languages : en
Pages : 326

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Book Description
This work is intended to portray the interrelationship of heredity, individual development, and the evolution of species in a way that can be understood by nonspecialists. In striving to offer a straightforward historical exposition of the complex topic of nature and nurture, the author tells the story through a central cast of characters beginning with Lamarck in 1809 and ending with a synthesis of his own that depicts how extragenetic behavioral changes in individual development could be the first stages in the pathway leading to evolutionary change. On the way to that goal, he describes relevant conceptual aspects of genetics, embryological development, and evolutionary biology in a nontechnical and accurate way for students and colleagues in the behavioral and social sciences. The book presents a highly selected review as a prelude to the description of a developmental theory of the phenotype in which behavioral change leads eventually to evolutionary change. This book grew out of an invited interdisciplinary course of lectures for advanced undergraduate and graduate students at the University of Colorado, Boulder. Presenting the various ways about thinking about heredity, individual development, and evolution, the author had three goals in mind: *to establish the relevance of individual development to the evolution of species; *to describe the most appropriate way to think about or conceptualize heredity in relation to individual development; *to show that this somewhat unorthodox manner of conceptualizing heredity and individual development gives rise to a new way to think about the behavioral pathway leading to evolution. In conclusion, the present work will provide a contribution toward the possible dissolution of the nature-nurture dichotomy, as well as a contribution to evolutionary theory.

Author: Arturas Petronis
Publisher: Springer Science & Business Media
ISBN: 3642174264
Category : Medical
Languages : en
Pages : 328

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Book Description
Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.

Author: L. Joseph Su
Publisher: Springer
ISBN: 1447166787
Category : Medical
Languages : en
Pages : 327

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Book Description
This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Author: Peter Gluckman
Publisher: Cambridge University Press
ISBN: 9780521847438
Category : Medical
Languages : en
Pages : 542

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Book Description
This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.

Author: F. Scott Hall
Publisher: Academic Press
ISBN: 0128016736
Category : Medical
Languages : en
Pages : 400

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Book Description
Epigenetics and Behavior: Exploring Biological Determinants of Behavior discusses the evolutionary basis of neurodevelopmental regulation of gene expression by experience (epigenetics). While many areas of scientific inquiry have sought to understand what determines the variation in human attributes (phenotypes) that have consistent trait-like features, including anxiety or fearlessness, aggressive or non-aggressive behavior, social or antisocial behavior, charitable or miserly traits, and so forth, this book takes a comprehensive approach. Over the lifespan of a particular individual, these traits, although flexible, are often highly consistent. The “nature-nurture or “genes versus environment discussion is one of the longstanding arguments in all philosophical inquiry. And now, as we stand on the threshold of a complete understanding of the most fundamental question about human nature, all a result of combined empirical and theoretical advances in epigenetics which influence developmental psychobiology and evolutionary biology, the science is rapidly progressing. With the advent of epigenetics, we now have a mechanism (or mechanisms, really) to explain how this process works at a molecular level – that is, evolutionary selected mechanisms of gene-environment interactions are literally “written into our genetic code. This book draws together the knowledge and ideas from the different fields that collectively have answered the “nature-nurture discussion. Integrates the findings of developmental psychobiology with epigenetics in an evolutionary context Written to convey a new perspective on epigenetic effects on behavior, while maintaining fluid writing prose for the uninformed reader Assembles knowledge from a number of fields, including developmental psychobiology, genomics, epigenetics, and evolutionary biology to paint a precise picture of epigenetic influences on personality

Author: Karin B. Michels
Publisher: Springer Science & Business Media
ISBN: 9400724942
Category : Medical
Languages : en
Pages : 450

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Book Description
The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!