Author: Raymond J. Bergeron
Publisher: CRC Press
ISBN: 9780849386794
Category : Medical
Languages : en
Pages : 438
Book Description
Representing an integration of basic and clinical sciences, this book focuses on new concepts in the design, synthesis, and testing of iron chelators for clinical application. It provides an overview of the pathophysiology of iron metabolism as it relates to the origins of iron-mediated tissue damage, and it clearly outlines successes and shortcomings of current iron chelation therapy in preventing such damage. The book also describes a number of other exciting potential therapeutic applications of iron chelators, such as in the treatment of malaria. Other topics covered include iron coordination chemistry, recent advances in synthetic methods for accessing iron chelators, siderophore models, subcellular iron storage targets, and the possible application of biotechnology in the production of therapeutically useful iron chelators. The book also describes new animal models for evaluating chelators.
The Development of Iron Chelators for Clinical Use
Author: Raymond J. Bergeron
Publisher: CRC Press
ISBN: 9780849386794
Category : Medical
Languages : en
Pages : 438
Book Description
Representing an integration of basic and clinical sciences, this book focuses on new concepts in the design, synthesis, and testing of iron chelators for clinical application. It provides an overview of the pathophysiology of iron metabolism as it relates to the origins of iron-mediated tissue damage, and it clearly outlines successes and shortcomings of current iron chelation therapy in preventing such damage. The book also describes a number of other exciting potential therapeutic applications of iron chelators, such as in the treatment of malaria. Other topics covered include iron coordination chemistry, recent advances in synthetic methods for accessing iron chelators, siderophore models, subcellular iron storage targets, and the possible application of biotechnology in the production of therapeutically useful iron chelators. The book also describes new animal models for evaluating chelators.
Publisher: CRC Press
ISBN: 9780849386794
Category : Medical
Languages : en
Pages : 438
Book Description
Representing an integration of basic and clinical sciences, this book focuses on new concepts in the design, synthesis, and testing of iron chelators for clinical application. It provides an overview of the pathophysiology of iron metabolism as it relates to the origins of iron-mediated tissue damage, and it clearly outlines successes and shortcomings of current iron chelation therapy in preventing such damage. The book also describes a number of other exciting potential therapeutic applications of iron chelators, such as in the treatment of malaria. Other topics covered include iron coordination chemistry, recent advances in synthetic methods for accessing iron chelators, siderophore models, subcellular iron storage targets, and the possible application of biotechnology in the production of therapeutically useful iron chelators. The book also describes new animal models for evaluating chelators.
Development of Iron Chelators for Clinical Use
Author: Arthur Earl Martell
Publisher: North-Holland
ISBN:
Category : Medical
Languages : en
Pages : 340
Book Description
Publisher: North-Holland
ISBN:
Category : Medical
Languages : en
Pages : 340
Book Description
Development of Iron Chelators for Clinical Use
Author: W. French Anderson
Publisher:
ISBN:
Category : Chelates
Languages : en
Pages : 292
Book Description
Publisher:
ISBN:
Category : Chelates
Languages : en
Pages : 292
Book Description
Development of Iron Chelators for Clinical Use
Author: Arthur Earl Martell
Publisher:
ISBN:
Category : Chelation therapy
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category : Chelation therapy
Languages : en
Pages :
Book Description
Iron Chelation Therapy
Author: Chaim Hershko
Publisher: Springer Science & Business Media
ISBN: 1461505933
Category : Science
Languages : en
Pages : 275
Book Description
Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).
Publisher: Springer Science & Business Media
ISBN: 1461505933
Category : Science
Languages : en
Pages : 275
Book Description
Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).
The Development of Iron Chelators for Clinical Use and the Molecular Mechanisms of Iron Metabolism in Normal and Neoplastic Cells
Author: Des R. Richardson
Publisher:
ISBN:
Category : Cell metabolism
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category : Cell metabolism
Languages : en
Pages :
Book Description
Development of Iron Chelators for Clinical Use
DEVELOPMENT OF IRON CHELATORS FOR CLINICAL USE- SYMPOSIUM- PAPERS- DEPARTMENT OF HEALTH, EDUCATION AND WELFARE- NATIONAL INSTITUTES OF HEALTH- PUBLIC HEALTH SERVICE- NATIONAL INSTITUTE OF ARTHRITIS, METABOLISM AND DIGESTIVE DISEASES.
Development of Iron Chelators for Clinical Use
Author: W. French Anderson
Publisher:
ISBN:
Category : Chelates
Languages : en
Pages : 0
Book Description
Publisher:
ISBN:
Category : Chelates
Languages : en
Pages : 0
Book Description