Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases PDF Download

Author: Pedro Augusto Reck dos Santos
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: P. Van Schil
Publisher: Nova Publishers
ISBN: 9781594544507
Category : Isolation perfusion (Physiology)
Languages : en
Pages : 254

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Book Description
Surgical resection of lung metastases is a widely accepted procedure but long-term results are disappointing with a 5-year survival rate of approximately 40%. The main prognostic factor is complete resection and a better survival is reported in patients with a single metastasis and a disease-free survival of more than 3 years. Re-operations are feasible but often patients become inoperable due to insufficient pulmonary reserve and new treatment modalities are looked for. Intravenous (iv) chemotherapy has no major impact on survival due to systemic side-effects when high doses are given. As isolated limb and liver perfusion, isolated lung perfusion (ILuP) has the advantage of selectively delivering an agent into the lung while diverting the venous effluent. This allows the drug to be given in a significantly higher dose compared to iv therapy, while drug levels in the other organs are kept low enough to avoid major complications. ILuP has been shown to be very effective for the treatment of lung metastases in animal models. Phase I clinical studies to determine dose-limiting toxicity and maximum tolerated dose have recently been reported. The principal aim of this book is to discuss the current treatment of lung metastases and the possible contribution of ILuP.

Author: Leonard Weiss
Publisher: Macmillan Reference USA
ISBN:
Category : Medical
Languages : en
Pages : 362

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Author: Domenico Ribatti
Publisher: Academic Press
ISBN: 0128194944
Category : Science
Languages : en
Pages : 198

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Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment

Author: Joel A. Kaplan
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 456

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This comprehensive text delivers cutting-edge scientific knowledge and expert clinical guidance on anesthesia for the vascular surgical patient or the patient with cardiac disease undergoing major noncardiac surgery. It covers cardiovascular anatomy, physiology, and pharmacology; preoperative assessment and management, specific perioperative considerations, and postoperative management. This 2nd Edition features eight completely rewritten chapters and six new chapters. Extensive updates throughout reflect all the new procedures, drugs, techniques, and monitoring modalities that have emerged over the last decade. Delivers cutting-edge scientific knowledge that serves as a basis for clinical practice. Provides comprehensive coverage of anesthesia, including cardiovascular anatomy, physiology, and pharmacology preoperative assessment and management specific perioperative considerations and postoperative management. Integrates recent developments from the fields of anesthesiology, cardiology, cardiovascular pharmacology, vascular surgery, and critical care medicine to present a complete clinical picture Offers fresh perspectives from many new contributors who are leaders in their fields. Explores all the new procedures, drugs, techniques, and monitoring modalities that have emerged over the last decade. Devotes more coverage to regional anesthesia or combined regional and general anesthesia for modification of stress responses, improved pain control, better wound healing, and control of inflammatory/immunomodulatory changes associated with surgery. Places increased emphasis on the physiology, diseases, and surgery of the peripheral vasculature throughout, including a new chapter on The Peripheral Circulation in Patients with Vascular Disease (Chapter 1). Includes a new chapter on Imaging of the Vasculature(Chapter 2), that is completely up to date and easy to read. Covers anesthesia and perioperative care for all of the latest procedures, including new information on minimally invasive techniques and new chapters on Interventional Vascular Radiologic Procedures (Chapter 4) and Choice of Invasive vs. Noninvasive Surgery (Chapter 7). Features expanded material on postoperative care, especially on new techniques for pain management, and includes new chapters on Respiratory Complications and Management (Chapter 18) and Ethical Decisions/End of Life Care in Patients with Vascular Disease (Chapter 20).

Author: Simon S. Lo
Publisher: Springer Science & Business Media
ISBN: 364225604X
Category : Medical
Languages : en
Pages : 433

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Book Description
Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Author: Guido Bocci
Publisher: Springer
ISBN: 3662436043
Category : Medical
Languages : en
Pages : 302

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This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Author: Alexander A. Kokhanovsky
Publisher: Springer Science & Business Media
ISBN: 3642321062
Category : Science
Languages : en
Pages : 653

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Book Description
Light scattering review (vol 8) is aimed at the presentation of recent advances in radiative transfer and light scattering optics. The topics to be covered include: scattering of light by irregularly shaped particles suspended in atmosphere (dust, ice crystals), light scattering by particles much larger as compared the wavelength of incident radiation, atmospheric radiative forcing, astrophysical radiative transfer, radiative transfer and optical imaging in biological media, radiative transfer of polarized light, numerical aspects of radiative transfer.

Author: Stavros V. Konstantinides
Publisher: Springer Science & Business Media
ISBN: 1597452874
Category : Medical
Languages : en
Pages : 273

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This practical volume highlights traditional, novel, and evolving aspects of the diagnosis and treatment of pulmonary embolism (PE). The contributors comprise an international team of experts. Important aspects of diagnosis, risk stratification, and differential treatment of patients with PE are presented in a concise, yet comprehensive manner. Emphasis is placed on specific issues related to PE, including pregnancy, cancer, thrombophilia, and air travel.

Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309457971
Category : Medical
Languages : en
Pages : 145

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Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.