Design, Synthesis, and Characterization of Dicholinium-based Ionic Liquids for Drug Delivery and Materials Science Applications PDF Download
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Author: Moira Marie Esson Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
Ionic liquids are exceptionally unique molecules, composed of cationic and anionic constituents, whose numerous advantageous properties have promoted their use in both the pharmaceutical sciences and the materials sciences. A large majority of the drugs on the market or in the pipeline are highly potent yet exhibit significant hydrophobic character. These drugs require careful formulation to allow for use in the clinic. The extraordinary ability of ionic liquids to dissolve a wide variety of compounds has facilitated their use in the pharmaceutical sciences and renders them advantageous for their use in nanoemulsion drug delivery vehicles. This work, in part, investigates the use of hydrophobic ionic liquids as components in nanoemulsion drug delivery vehicles. In this thesis hydrophobic dicationic cholinium-based ionic liquids have been synthesized and formulated to leverage the unique properties of ionic liquids to solubilize large amounts of various pharmaceutical agents. The dicationic cholinium-based cationic architecture was specifically designed to be biocompatible and mitigate any toxic effects typically associated with ionic liquid cationic architectures used for the formulation of hydrophobic ionic liquids. The hydrophobic dicationic cholinium-based ionic liquids can be successfully used as a component in the hydrophobic media for the formulation of oil-in-water nanoemulsions for intravenous delivery of pharmaceutical agents. Stable nanoemulsions composed with the hydrophobic dicationic cholinium-based ionic liquids were successfully formulated for the antifungal agent Amphotericin B, the hydrophobic chemotherapeutic agent paclitaxel, and the hydrophilic chemotherapeutic cisplatin. The formulations show high drug loading, and prolonged in vitro release of the drugs. The use of ionic liquid crystals has attracted considerable attention in the materials science due to the fact they combine the advantageous properties of ionic liquids and liquid crystals. We also investigate the counterion dependent mesophase behaviors of the ionic liquid crystals composed of the novel dicationic cholinium-based architecture. These studies demonstrate the benefits of using hydrophobic ionic liquids as components in nanoemulsions for intravenous drug delivery. Moreover, these studies demonstrate the advantageous design of the dicationic cholinium-based architecture.
Author: Moira Marie Esson Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
Ionic liquids are exceptionally unique molecules, composed of cationic and anionic constituents, whose numerous advantageous properties have promoted their use in both the pharmaceutical sciences and the materials sciences. A large majority of the drugs on the market or in the pipeline are highly potent yet exhibit significant hydrophobic character. These drugs require careful formulation to allow for use in the clinic. The extraordinary ability of ionic liquids to dissolve a wide variety of compounds has facilitated their use in the pharmaceutical sciences and renders them advantageous for their use in nanoemulsion drug delivery vehicles. This work, in part, investigates the use of hydrophobic ionic liquids as components in nanoemulsion drug delivery vehicles. In this thesis hydrophobic dicationic cholinium-based ionic liquids have been synthesized and formulated to leverage the unique properties of ionic liquids to solubilize large amounts of various pharmaceutical agents. The dicationic cholinium-based cationic architecture was specifically designed to be biocompatible and mitigate any toxic effects typically associated with ionic liquid cationic architectures used for the formulation of hydrophobic ionic liquids. The hydrophobic dicationic cholinium-based ionic liquids can be successfully used as a component in the hydrophobic media for the formulation of oil-in-water nanoemulsions for intravenous delivery of pharmaceutical agents. Stable nanoemulsions composed with the hydrophobic dicationic cholinium-based ionic liquids were successfully formulated for the antifungal agent Amphotericin B, the hydrophobic chemotherapeutic agent paclitaxel, and the hydrophilic chemotherapeutic cisplatin. The formulations show high drug loading, and prolonged in vitro release of the drugs. The use of ionic liquid crystals has attracted considerable attention in the materials science due to the fact they combine the advantageous properties of ionic liquids and liquid crystals. We also investigate the counterion dependent mesophase behaviors of the ionic liquid crystals composed of the novel dicationic cholinium-based architecture. These studies demonstrate the benefits of using hydrophobic ionic liquids as components in nanoemulsions for intravenous drug delivery. Moreover, these studies demonstrate the advantageous design of the dicationic cholinium-based architecture.
Author: Sanchayita Rajkhowa Publisher: John Wiley & Sons ISBN: 3527350667 Category : Science Languages : en Pages : 533
Book Description
Handbook of Ionic Liquids A one-stop reference for researchers interested in ionic liquids and their applications Handbook of Ionic Liquids: Fundamentals, Applications, and Sustainability, constitutes an overview of the latest advances in ionic liquid chemistry. It offers a comprehensive summary of the development history of ionic liquids, their design, and the diverse array of applications—including green and sustainable synthesis, catalysis, drug development and medicine, biotechnology, materials science, and electrochemistry. The authors explain a variety of processes used to develop novel materials with ionic liquids and describe likely future developments using practical examples taken from contemporary research and development in the field. The book includes discussions of biomass conversion, CO2 capture, and more. You’ll also discover: A thorough introduction to the theory of ionic liquids, as well as their different types and recycling methods Comprehensive explorations of the physico-chemical properties of ionic liquids Practical discussions of ionic liquid synthesis and analysis, including green synthesis and heterocyclic chemistry applications Summary of the use of ionic liquids in materials science, including polymers, energy conversion, and storage devices Perfect for organic, catalytic, physical, analytical, and environmental chemists, Handbook of Ionic Liquids: Fundamentals, Applications, and Sustainability will also benefit electrochemists, materials scientists, and biotechnologists with an interest in ionic liquids and their application.
Author: Masahiro Goto Publisher: Springer Nature ISBN: 9811643652 Category : Science Languages : en Pages : 246
Book Description
This book presents recent advances in the use of ionic liquids in medicine and pharmaceutics with particular emphasis on addressing critical pharmaceutical challenges, including the low solubility, polymorphism, and bioavailability of drugs. It also provides insights into the development of the biologically functionalized ionic liquids suitable for medical and pharmaceutical applications. Ionic liquids have been used as potential solvents or materials in the fields of pharmaceutical drug delivery and formulations because of their unique and tunable physicochemical and biological properties. Readers find explanations of the diverse approaches to the application of ionic liquids in drug solubility, active pharmaceutical ingredient (API) formulation, and drug delivery systems, such as topical, transdermal, and oral delivery, with particular emphasis on recent developments. Particular attention is given to the development of ionic liquid-assisted effective drug delivery techniques for sparingly soluble or insoluble drug molecules. This book also discusses the biological activities of ionic liquids for possible applications in drug formulation and drug delivery systems. Scientists in disciplines such as chemistry, biology, and pharmaceutics find this book instructive and informative for developing ionic liquid-based drug formulations or drug delivery systems.
Author: Rasmus Fehrmann Publisher: John Wiley & Sons ISBN: 3527324291 Category : Science Languages : en Pages : 498
Book Description
This unique book gives a timely overview about the fundamentals and applications of supported ionic liquids in modern organic synthesis. It introduces the concept and synthesis of SILP materials and presents important applications in the field of catalysis (e.g. hydroformylation, hydrogenation, coupling reactions, fine chemical synthesis) as well as energy technology and gas separation. Written by pioneers in the field, this book is an invaluable reference book for organic chemists in academia or industry.
Author: Rasmus Fehrmann Publisher: Walter de Gruyter GmbH & Co KG ISBN: 3110582120 Category : Science Languages : en Pages : 175
Book Description
The current book brings together the latest developments in the area of ionic liquids, including synthesis, purity control, toxicity, and scaling-up technologies. In addition, the authors explore the applications of ionic liquids in organic synthesis and catalysis, separation techniques and nanomaterials engineering. Written by key experts in the field, this book is an invaluable material for organic and green chemists in academia and industry.
Author: Scott Handy Publisher: BoD – Books on Demand ISBN: 9533076054 Category : Science Languages : en Pages : 532
Book Description
This volume, of a two volume set on ionic liquids, focuses on the applications of ionic liquids in a growing range of areas. Throughout the 1990s, it seemed that most of the attention in the area of ionic liquids applications was directed toward their use as solvents for organic and transition-metal-catalyzed reactions. Certainly, this interest continues on to the present date, but the most innovative uses of ionic liquids span a much more diverse field than just synthesis. Some of the main topics of coverage include the application of RTILs in various electronic applications (batteries, capacitors, and light-emitting materials), polymers (synthesis and functionalization), nanomaterials (synthesis and stabilization), and separations. More unusual applications can be noted in the fields of biomass utilization, spectroscopy, optics, lubricants, fuels, and refrigerants. It is hoped that the diversity of this volume will serve as an inspiration for even further advances in the use of RTILs.
Author: Jamal Akhter Siddique Publisher: Elsevier ISBN: 0323984002 Category : Science Languages : en Pages : 569
Book Description
Advanced Applications of Ionic Liquids discusses the intersection of nanotechnology with ionic liquids (ILs) and materials, along with opportunities for advanced engineering applications in various research fields. Novel materials at nano scales with ILs creates an upsurge in the thermal and electrochemical constancy of the nano scale particles, making them ideal for industrial applications. The implementation of ILs at nano scale includes an interaction of constituents, which is beneficial for electron transfer reactions. These new composites can be implemented as sensors, electronics, catalysts and photonics. Including ILs in polymer composites enhance electrochemical consistency, govern particle size, upsurge conductivity, reduce toxicity, and more. This book is a comprehensive reference for researchers working with IL based technologies for environmental and energy applications. - Covers all industrial aspects and advanced applications of ionic liquids (ILs) - Discusses the advanced applications of ILs across multiple fields, including industrial chemistry and chemical engineering - Includes a discussion of the use of ionic liquids in functional polymers, with applications for catalysis, energy conservation, sensors, and more
Author: Anson Brooks Publisher: Nova Science Publishers ISBN: 9781631177163 Category : Ionic solutions Languages : en Pages : 0
Book Description
Research into ionic liquids (ILs) has been a very rapidly growing discipline in recent years. ILs have attracted very considerable attention because of their unique properties, which may be useful in new processes and technologies. They have already been studied for a variety of applications such as alternative solvents in organic synthesis and catalysis, reaction media for biocatalysis and biotransformation, in the separation sciences, electrolytes in batteries and solar cells, alternative lubricants, and as media for tissue preservation. ILs have excellent solvation properties, are thermally, chemically and electrochemically stable, and their vapour pressure is negligible. Nevertheless, the same properties that make them attractive replacements for other volatile industrial compounds may render them hazardous to ecosystems. This book discusses several topics that include the pharmaceutical aspect of ILs; the application of ILs to lignin extraction and depolymerisation; recent developments in ionic liquid toxicity assessments; the role temperature, irradiation and oxidation has on the stability of ILs; and analytical methods for determining the constituents of ILs.
Author: Inamuddin Publisher: Springer Nature ISBN: 3030449955 Category : Science Languages : en Pages : 408
Book Description
Numerous solvents used in chemical processes have poisonous and unsafe properties that pose significant ecological concerns ranging from atmospheric emissions to the contamination of water effluents. To combat these ecological threats, over the course of the past two decades, the field of green chemistry has grown to develop more natural reaction processes and techniques involving the use of nonconventional solvents to diminish waste solvent production and thus decrease negative impact on the environment. Ionic liquids in particular are more environmentally friendly substitutes to conventional solvents, and as such, have seen more widespread use in the past decade. They have been used in such processes as extraction, separation, purification of organic, inorganic, and bioinorganic compounds, reaction media in biochemical and chemical catalysis, green organic and drug synthesis, among other industrial applications. Thus, in proving themselves a suitable greener media for economic viability in chemical processes, ionic liquids are leading to more sustainable development. This edition explores the application of ionic liquids as a green solvent. It contains a state-of-the-art overview on ionic liquids as green solvents for chemical processes and techniques, as well as some of their useful industrial applications.
Author: Moira Marie Esson
Author: Moira Marie Esson
Author: Sanchayita Rajkhowa
Author: Masahiro Goto
Author: Rasmus Fehrmann
Author: Rasmus Fehrmann
Author: 
Author: Scott Handy
Author: Jamal Akhter Siddique
Author: Anson Brooks
Author: Inamuddin