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Author: Justin McKennon Publisher: LAP Lambert Academic Publishing ISBN: 9783659525124 Category : Languages : en Pages : 60
Book Description
The field of microfluidics has been an emerging area of popular research in the fields of science and engineering since it first emerged in the early 1980s. Residing at the intersection of engineering, chemistry, physics, and biology, microfluidics problems have posed some of the greatest challenges of science in recent times. Due to the extreme difficulty in manipulating, measuring, and controlling the fluid volumes and velocities associated with microfluidics applications, many significant scientific advances have been held out of reach. Of the all the bottlenecks associated with microfluidics, the accurate measurement and characterization of fluids in these systems has proven to be one of the most challenging. Sensors in this category are constrained to geometrically minute spaces, typically on the sub-millimeter scale, making conventional measurement techniques obsolete for many applications. This book discusses the analysis and fabrication techniques associated with designing, building, and testing a microfluidic flow rate and temperature sensor.
Author: Justin McKennon Publisher: LAP Lambert Academic Publishing ISBN: 9783659525124 Category : Languages : en Pages : 60
Book Description
The field of microfluidics has been an emerging area of popular research in the fields of science and engineering since it first emerged in the early 1980s. Residing at the intersection of engineering, chemistry, physics, and biology, microfluidics problems have posed some of the greatest challenges of science in recent times. Due to the extreme difficulty in manipulating, measuring, and controlling the fluid volumes and velocities associated with microfluidics applications, many significant scientific advances have been held out of reach. Of the all the bottlenecks associated with microfluidics, the accurate measurement and characterization of fluids in these systems has proven to be one of the most challenging. Sensors in this category are constrained to geometrically minute spaces, typically on the sub-millimeter scale, making conventional measurement techniques obsolete for many applications. This book discusses the analysis and fabrication techniques associated with designing, building, and testing a microfluidic flow rate and temperature sensor.
Author: Sergey Yurish Publisher: Lulu.com ISBN: 8409174928 Category : Languages : en Pages : 349
Book Description
Proceedings of the 5th International Conference on Sensors and Electronic Instrumentation Advances SEIA' 2019), 25-27 September 2019, Tenerife (Canary Islands), Spain. The coverage includes: various physical sensors, gas sensors, optical and fiber optical sensors and systems, biosensors, sensors networks and applications.
Author: Hyun Chul Jung Publisher: ISBN: Category : Electrokinetics Languages : en Pages : 81
Book Description
Abstract: The objective of this thesis is to design and fabricate microfluidic devices for study of the fluid transport at the microscale and development of devices for biomedical applications, such as transport and manipulation of nanoparticles and biomolecules. For device fabrication, several materials including silicon, Pyrex glass, and polymer were explored. Inductively-coupled plasma reactive ion etching (ICP-RIE) was employed for fabrication of microfluidic channels on silicon and Pyrex glass and photolithography of SU-8 polymer was used to pattern microfluidic channels. The etching of Pyrex glass was carried out using SF6/Ar plasma. The etch rate and surface and sidewall smoothness were investigated systematically for dependence on bias voltage, ICP power, pressure, flow rate, and cathode temperature. Near vertical sidewalls and smooth etched surfaces were obtained by optimized etching parameters. The maximum etch rate, 0.65 um/min, was achieved at a pressure of 5 mTorr, a bias of 720 V, and an ICP power of 2500 W. For device packaging four types of bonding techniques (Fusion bonding, Anodic bonding, PDMS bonding, and SU-8 bonding) were investigated and optimized. . Microfluidic devices with five crosses for creating extensive and rotational flow patterns were designed and fabricated on silicon etched by ICP-RIE. The devices were bonded with Pyrex glass by anodic wafer bonding and packaged on a carrier using wire bonding before characterization. Under a DC bias, extensional flow of polystyrene beads has been demonstrated in a 20 um wide and 10 um deep 5 cross microfluidic device. Using the COMSOL software, Incompressible Navier Stokes equations and Conductive media DC modes were employed to simulate the electrokinetic flows by applying specific DC biasing boundary conditions. . The simulated results have a good agreement with the extensional flow observed on the fabricated devices.
Author: Wing Cheung Mak Publisher: Elsevier ISBN: 012823847X Category : Technology & Engineering Languages : en Pages : 370
Book Description
Microfluidic Biosensors provides a comprehensive overview covering the most recent emerging technologies on the design, fabrication, and integration of microfluidics with transducers. These form various integrated microfluidic biosensors with device configurations ranging from 2D to 4D levels. Coverage also includes advanced printed microfluidic biosensors, flexible microfluidics for wearable biosensors, autonomous lab-on-a-chip biosensors, CMOS-base microanalysis systems, and microfluidic devices for mobile phone biosensing. The editors and contributors of this book represent both academia and industry, come from a varied range of backgrounds, and offer a global perspective. This book discusses the design and principle of microfluidic systems and uses them for biosensing applications. The microfluidic fabrication technologies covered in this book provide an up-to-date view, allowing the community to think of new ways to overcome challenges faced in this field. The focus is on existing and emerging technologies not currently being analyzed extensively elsewhere, providing a unique perspective and much-needed content. The editors have crafted this book to be accessible to all levels of academics from graduate students, researchers, and professors working in the fields of biosensors, microfluidics design, material science, analytical chemistry, biomedical devices, and biomedical engineering. It can also be useful for industry professionals working for microfluidic device manufacturers, or in the industry of biosensors and biomedical devices. Presents an in-depth overview of microfluidic biosensors and associated emerging technologies such as printed microfluidics and novel transducers Addresses a range of microfluidic biosensors with device configurations ranging from 2D to 4D levels Includes the commercialization aspects of microfluidic biosensors that provide insights for scientists and engineers in research and development
Author: Dan E. Angelescu Publisher: Artech House ISBN: 159693980X Category : Technology & Engineering Languages : en Pages : 269
Book Description
The recent development of microfluidics has lead to the concept of lab-on-a-chip, where several functional blocks are combined into a single device that can perform complex manipulations and characterizations on the microscopic fluid sample. However, integration of multiple functionalities on a single device can be complicated. This a cutting-edge resource focuses on the crucial aspects of integration in microfluidic systems. It serves as a one-stop guide to designing microfluidic systems that are highly integrated and scalable. This practical book covers a wide range of critical topics, from fabrication techniques and simulation tools, to actuation and sensing functional blocks and their inter-compatibility. This unique reference outlines the benefits and drawbacks of different approaches to microfluidic integration and provides a number of clear examples of highly integrated microfluidic systems.
Author: Nam-Trung Nguyen Publisher: William Andrew ISBN: 1437735215 Category : Science Languages : en Pages : 369
Book Description
The ability to mix minute quantities of fluids is critical in a range of recent and emerging techniques in engineering, chemistry and life sciences, with applications as diverse as inkjet printing, pharmaceutical manufacturing, specialty and hazardous chemical manufacturing, DNA analysis and disease diagnosis. The multidisciplinary nature of this field – intersecting engineering, physics, chemistry, biology, microtechnology and biotechnology – means that the community of engineers and scientists now engaged in developing microfluidic devices has entered the field from a variety of different backgrounds. Micromixers is uniquely comprehensive, in that it deals not only with the problems that are directly related to fluidics as a discipline (aspects such as mass transport, molecular diffusion, electrokinetic phenomena, flow instabilities, etc.) but also with the practical issues of fabricating micomixers and building them into microsystems and lab-on-chip assemblies.With practical applications to the design of systems vital in modern communications, medicine and industry this book has already established itself as a key reference in an emerging and important field. The 2e includes coverage of a broader range of fabrication techniques, additional examples of fully realized devices for each type of micromixer and a substantially extended section on industrial applications, including recent and emerging applications. Introduces the design and applications of micromixers for a broad audience across chemical engineering, electronics and the life sciences, and applications as diverse as lab-on-a-chip, ink jet printing, pharmaceutical manufacturing and DNA analysis Helps engineers and scientists to unlock the potential of micromixers by explaining both the scientific (microfluidics) aspects and the engineering involved in building and using successful microscale systems and devices with micromixers The author's applied approach combines experience-based discussion of the challenges and pitfalls of using micromixers, with proposals for how to overcome them
Author: Matthew J. Waldron Publisher: ISBN: Category : Biomedical engineering Languages : en Pages : 354
Book Description
"The design, simulation, and fabrication of a flow sensor to be integrated into an implantable micropump is presented. The flow sensor operates by the method of thermal anemometry, in which heat is dissipated from a resistive element held in the flow of the fluid. The rate at which heat is carried away is dependent on the flow rate and is directly related to the thermal conductance. A control circuit utilizing the constant-temperature anemometry mode of operation is used to generate a change in voltage in response to change in thermal conductance, and subsequently, flow rate. A mathematical expression describing the sensor sensitivity based on thermal effects is proposed, based on the thermal spreading resistance and basic heat transfer laws. The mathematical model is refined using finite-element analysis, and a complete formulation for the effect of sensor area, length-to-width ratio, and fluid velocity on thermal spreading resistance is determined. the refined thermal spreading conductance equation can be used to replace assumptions made in initial mathematical analysis. An original fabrication process is presented and investigated, in which a p-doped polysilicon bridge is encapsulated in silicon oxide and silicon nitride using surface micromachining techniques. A sacrificial polysilicon layer and KOH etching are used to form half of the complete fluid channel in the bulk of the silicon wafer. When the fluid channel is sealed with a complementarity etched wafer, the sensor bridge is situated in the middle of the fluid channel, optimally placed for maximum sensitivity. The fabrication process yields functional sensor bridges, with even the most fragile sensor shape withstanding the process. An analog constant-temperature control circuit is developed, based upon a Wheatstone bridge with a feedback op-amp. The circuit produces an output voltage dependent on thermal resistance,e and will reduce the effect of fluid temperature fluctuations on circuit output. This relies on introducing a second sensor bridge into the fluid channel, and limiting its self-heating. A design based on replacing one element in the Wheatstone bridge with a 'transimpedance virtual resistor,' and another design based on reducing the power to one leg of the bridge are simulated, and their performance compared. PSPICE simulations are used to optimize the circuits in order to maximize the ratio of sensitivity to fluid velocity to sensitivity to ambient temperature."--Abstract.
Author: Nam-Trung Nguyen Publisher: Artech House ISBN: 1630813656 Category : Technology & Engineering Languages : en Pages : 576
Book Description
Now in its Third Edition, the Artech House bestseller, Fundamentals and Applications of Microfluidics, provides engineers and students with the most complete and current coverage of this cutting-edge field. This revised and expanded edition provides updated discussions throughout and features critical new material on microfluidic power sources, sensors, cell separation, organ-on-chip and drug delivery systems, 3D culture devices, droplet-based chemical synthesis, paper-based microfluidics for point-of-care, ion concentration polarization, micro-optofluidics and micro-magnetofluidics. The book shows how to take advantage of the performance benefits of microfluidics and serves as an instant reference for state-of-the-art microfluidics technology and applications. Readers find discussions on a wide range of applications, including fluid control devices, gas and fluid measurement devices, medical testing equipment, and implantable drug pumps. Professionals get practical guidance in choosing the best fabrication and enabling technology for a specific microfluidic application, and learn how to design a microfluidic device. Moreover, engineers get simple calculations, ready-to-use data tables, and rules of thumb that help them make design decisions and determine device characteristics quickly.
Author: Jaime Castillo-León Publisher: Springer ISBN: 3319086871 Category : Technology & Engineering Languages : en Pages : 246
Book Description
This book covers all the steps in order to fabricate a lab-on-a-chip device starting from the idea, the design, simulation, fabrication and final evaluation. Additionally, it includes basic theory on microfluidics essential to understand how fluids behave at such reduced scale. Examples of successful histories of lab-on-a-chip systems that made an impact in fields like biomedicine and life sciences are also provided. This book also: · Provides readers with a unique approach and toolset for lab-on-a-chip development in terms of materials, fabrication techniques, and components · Discusses novel materials and techniques, such as paper-based devices and synthesis of chemical compounds on-chip · Covers the four key aspects of development: basic theory, design, fabrication, and testing · Provides readers with a comprehensive list of the most important journals, blogs, forums, and conferences where microfluidics and lab-on-a-chip news, methods, techniques and challenges are presented and discussed, as well as a list of companies providing design and simulation support, components, and/or developing lab-on-a-chip and microfluidic devices.
Author: Justin McKennon
Author: Justin McKennon
Author: 
Author: Sergey Yurish
Author: Hyun Chul Jung
Author: Wing Cheung Mak
Author: Dan E. Angelescu
Author: Nam-Trung Nguyen
Author: Matthew J. Waldron
Author: Nam-Trung Nguyen
Author: Jaime Castillo-León