DSIP PDF Download

Author: Heinrich Ernst Kaeser
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author:
Publisher: S. Karger AG (Switzerland)
ISBN: 9783805540117
Category : Medical
Languages : en
Pages : 76

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Author: Andreas Ernst
Publisher:
ISBN:
Category :
Languages : en
Pages : 364

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Author: Guido A. Schoenenberger
Publisher:
ISBN:
Category :
Languages : en
Pages : 11

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Delta-Sleep-Inducing-Peptide (DSIP) beside humoral sleep induction acts upon the circadian rhythmicity of the locomotor activity and transmitter concentrations in the brain as well as on that of plasma proteins and cortisol levels in rats. It influences the prolactine levels and the circadian activity of N-Acetyl Transferase. DSIP in humans was found to exert a bell shaped dose response curve exhibiting an activating effect during awake states in situations conductive to sleep. Clinically and statistically significant effects upon sleep architecture were seen from 1h through up to 20h after injection; adverse effects were never observed. Single dose treatments of insomnia showed significant normalization effects of DSIP in all sleep parameters as did repeated administrations in chronic insomniacs. Daytime performance were found to improve after DSIP injections which at higher dose exerted a beneficiary effect in organic insomniacs. The peptide was able to suppress withdrawal effects in benzodiazepine addicts and normalized sleep patterns in narcoleptic patients.

Author: V.M. Monnier
Publisher: Birkhäuser
ISBN: 303485577X
Category : Science
Languages : en
Pages : 26

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The present work was done, as concerns the chemical-synthetical part, at the Institute for Organic Chemistry of the University Basel under the supervision of Prof. Dr. M. Brenner, as concerns the biological part, at the Laboratory for Sleep Research of the Physiological Institute of the University under the supervision of Prof. Dr. M. Monnier. I should like to express my gratitude to PD Dr. G.A. Schoenenberger who suggested the subject of this thesis and provided precious advice for its realization. I am very much indebted to Prof. Dr. M. Brenner who directed the synthetic work of the tripeptide. I am also grateful to my father Prof. Dr. M. Monnier and his coworkers L. Dudler and R. Gachter who tested the activity of the synthetical tripeptide. I also thank M. Grogg, Bachem, Liestal, for his help as concerns hydrogenoly sis reactions and E. von Arx for amino acid analysis at the Chromatogra phie-Labor, Pharma-Forschung, CIBA-GEIGY AG, Basel. 7 Abbreviations The abbreviations for amino acid derivatives, protecting groups and further helper groups are employed according to the recommendations of the IUPAC-IUB Commis sion on Biochemical Nomenclature which are reported in Biochem. J. 126, 773-780 (1972). Amino acids without symbol for the direction of rotation have the L-configu ration.

Author: Shōjirō Inoue
Publisher:
ISBN:
Category : Insomnia
Languages : en
Pages : 226

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Author: Vincent M. Monnier
Publisher:
ISBN:
Category : Peptides
Languages : fr
Pages : 27

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Author: Shojiro Inoue
Publisher: CRC Press
ISBN: 1000141586
Category : Medical
Languages : en
Pages : 220

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All aspects of sleep sciences are included in this excellent resource text, with special reference to sleep substances and sleep modulators. The historical development of the theories of sleep are reviewed in conjunction with the technical problems. All candidate substances are overviewed as to their sites of presence, chemical nature, bioassay techniques, physiological and pharmacological effects. On the basis of a standardized methodology developed by the author, sleep-modulatory characteristics of some substances are compared and evaluated in quantitative terms. The sleep regulatory mechanisms, which are composed of complex neurohumoral subsystems, are analyzed from the results of recent neurophysiological and neuroendocrinological experiments. Furthermore, an evolutionary aspect of sleep substances is taken into consideration. Chapters Highlight: Techniques for isolation and evaluation Prostaglandins Paradoxical sleep factors Sleep-promoting substances and nucleosides

Author: Shojiro Inoué
Publisher: VSP
ISBN: 9789067640589
Category : Science
Languages : en
Pages : 284

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This volume provides the first major overview, by eminent authorities on the subject, of recent developments in the field of endogenous substances and their regulation of sleep processes. The first two sections discuss general aspects of sleep regulation; including an historical overview, the restorative and adaptive functions of sleep, and evolutionary features. The third section contains contributions focussing on circadian rhythms in relation to humoral factors, hormones, neurotransmitters and metabolism. The sleep substances currently receiving most attention --- delta-sleep-inducing-peptide (DSIP), muramyl peptides, interleukin-1, sleep-promoting substance (SPS) and prostaglandin D2 --- are extensively discussed. Substances that may selectively modulate REM sleep are dealt with in the final section.

Author: Anthony Kales
Publisher: Springer Science & Business Media
ISBN: 3642578365
Category : Medical
Languages : en
Pages : 603

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Book Description
A review of the current state of the clinical and basic science of the pharmacology of sleep. The information provided ranges from a historical perspective to current concepts of sleep mechanisms, including the interaction between pharmacology and sleep-wake regulation and between chronopahrmacology and sleep-wake rhythms. For the first time in one single volume, both the basic mechanisms of sleep, and the basic and clinical aspects of the pharmacology of sleep are dealt with in a thorough, comprehensive and authoritative manner. The chapters, written by the foremost scientific authorities in this field, integrate the latest information on the basic mechanisms of drugs as they relate to their effects on sleep.