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Author: Wafik S. El-Deiry Publisher: Springer Science & Business Media ISBN: 159259851X Category : Medical Languages : en Pages : 374
Book Description
An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.
Author: Wafik S. El-Deiry Publisher: Springer Science & Business Media ISBN: 159259851X Category : Medical Languages : en Pages : 374
Book Description
An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.
Author: Holger Kalthoff Publisher: Springer Science & Business Media ISBN: 3642030459 Category : Medical Languages : en Pages : 286
Book Description
Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events. Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells. This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.
Author: Olivier Micheau Publisher: Springer ISBN: 3319568051 Category : Medical Languages : en Pages : 320
Book Description
This volume provides the current understanding of death receptor's/TLR3 signaling regulation in cancer. Death receptors, including TRAIL-R1, TRAIL-R2, Fas and TNF-RI, owing to their ability to trigger apoptosis and to contribute to the elimination of cancer cells by the immune system have been considered, to variable extent, as important therapeutic targets for cancer therapy. But an increasing body of evidence suggests that some of these receptors may also contribute to tumorigenesis, or that new players such as TLR3 may be targeted for cancer therapy due to their ability to behave like death receptors.
Author: Seamus J. Martin Publisher: S. Karger AG (Switzerland) ISBN: 9783805565790 Category : Apoptosis Languages : en Pages : 0
Book Description
The past five years have witnessed an explosion of research efforts in the study of how cells die. This book provides an up-to-date overview of our current knowledge of apoptosis and how discoveries in this area impact on our understanding of cancer. By synthesizing many of the recent developments in this area and placing them in perspective, it fulfills an important need. All the contributions are written by experts in their respective fields. The first two chapters give a basic introduction to the cell death machinery and its role in tumor development and progression; subsequent chapters cover current aspects of apoptosis research, including the involvement of cell cycle-related proteins (e.g. cyclin-dependent kinases) in apoptosis, the role of Bcl-2, Bcr-Abl, Rb, p53 and myc in the regulation of cell death, and apoptosis in the context of specific neoplasms such as cancer of the prostate, kidney, leukemia and neuroblastoma. It is also discussed how insights into the regulation of apoptosis may be exploited for designing new drugs aimed at eliminating malignant cells. Compiling the most recent research results on the relationship between apoptosis and cancer in one handy volume, this book will provide a valuable reference for scientists working in cancer research as well as newcomers to the field.
Author: Roya Khosravi-Far Publisher: Springer Science & Business Media ISBN: 140206554X Category : Medical Languages : en Pages : 362
Book Description
Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.
Author: Julien Beyrath Publisher: ISBN: Category : Languages : en Pages : 222
Book Description
Evasion of apoptosis is one of the major hallmarks of cancer. Apoptosis is a physiologic mechanism leading to cell death involved in the clearance of cancer cells. Apoptosis can be triggered extracellularly by pro-apoptotic receptor agonists (PARAs), belonging to the tumor necrosis factor (TNF) family, activating the "extrinsic" pathway. Among PARAs, TRAIL (TNF-related apoptosis- inducing ligand) is of particular interest having the unique characteristic of inducing apoptosis in tumor cells while sparing normal ones. Four membrane-bound TRAIL specific receptors have been described: death receptors 4 and 5 (DR4 and DR5) that mediate the apoptogenic signal and two decoy receptors (DcR1 and DcR2) that do not transduce the apoptogenic signal, limiting the efficiency of recombinant TRAIL as a therapeutic. On the basis of previously reported peptidic sequences that bind to DR5, we have developed a set of synthetic multivalent molecules (named TRAIL mim/DR5) to systematically study the effect of peptide dimerization and trimerization on DR5 binding and selective DR5-mediated death induction. Our results revealed up to several thousand-fold increased affinities of TRAIL imi/DR5-receptor complexes on generation of divalent and trivalent molecules and that multivalent molecules triggered a substantial DR5-dependant apoptotic response in vitro and in vivo. Our results also revealed a cell-specific antagonism role oe the TRAIL mim/DR5 highlighting a limit in their potential use as therapeutics. Our work revealed the potential but also the limits of TRAIL mim/DR5, small molecules specifically targeting one specific receptor of TRAIL, as a new anti-cancer therapeutics.
Author: Mels Sluyser Publisher: Springer Science & Business Media ISBN: 9781402033032 Category : Medical Languages : en Pages : 388
Book Description
Novel drugs are being developed which interact with the programmed cell death (apoptotic) machinery in cancer cells, thereby causing these cells to commit suicide and to be removed from the body. Research is also directed to investigate why the cancer cells sometimes lose the ability to undergo apoptosis after a certain period of time and methods are being developed to reactivate this cell death process. This book is intended for workers in the field and clinicians as a useful guide of the state of affairs in this exciting field which may offer more effective possibilities for treatment of cancer patients. Mels Sluyser is the Editor of the journals APOPTOSIS and ANTI-CANCER DRUGS. He brings together a collection of papers written by the world’s leading experts in these fields.
Author: Klaus-Michael Debatin Publisher: Wiley-Blackwell ISBN: Category : Medical Languages : en Pages : 712
Book Description
Since most cancer therapies primarily act by inducing apoptosis in tumor cells, insights into the molecular mechanisms regulating apoptosis are crucial to developing novel, more effective treatment strategies. Here, a highly distinguished team of authors from top institutes around the world leads readers from the principles of programmed cell death to the role of apoptosis in cancer development and emerging treatment strategies. Divided into two distinct parts, the first focuses on apoptosis signaling, covering in depth such topics as mitochondria, effector systems, the Bcl-2 family, IAPs, survival pathways, tumor suppressor genes, modulators, lysosomes and phagocytosis. The second section goes on to analyze apoptosis in cancer and cancer therapy, with a detailed look at model systems, molecular diagnosis, cellular stress, DNA damage and repair, molecular targets and therapeutic aspects. With its strong focus on recent developments in cancer therapy, this book is aimed at oncologists, molecular and cell biologists, biochemists, and those working in the pharmaceutical and biotechnological industries.
Author: Michael R. Hamblin Publisher: Artech House ISBN: 1596932783 Category : Medical Languages : en Pages : 601
Book Description
With today's focus on targeted and minimally invasive therapies, photodynamic therapy (PDT) is now being studied and used to combat many disease states and to investigate critical biological questions. This groundbreaking resource brings you the latest advances in photodynamic therapy and offers you a solid understanding of the design, delivery and dosimetry of the three basic ingredients of PDT - photosensitizers, light and oxygen. The book covers novel areas of mechanistic and innovative translational approaches. Moreover, it gives you an overview of the important medical applications of PDT, including approved treatments, clinical trials, and investigated therapies for cancer and non-malignant diseases.
Author: Wafik S. El-Deiry
Author: Wafik S. El-Deiry
Author: Holger Kalthoff
Author: Olivier Micheau
Author: Seamus J. Martin
Author: Roya Khosravi-Far
Author: Julien Beyrath
Author: Mels Sluyser
Author: Klaus-Michael Debatin
Author: Michael R. Hamblin
Author: Isaac Lasley