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Author: Niclas Thomas Publisher: ISBN: 9781985665675 Category : Languages : en Pages : 158
Book Description
Data science is a complex subject, but nevertheless one that can be made accessible to all through clear, intuitive explanations and worked examples. Existing software that forms the backbone of an immunologist's analytical toolkit (such as FlowJo and Prism) are expensive, inflexible and promotes a narrow mindset when it comes to analysing your data. On the other hand, the Python and R programming languages are open source, free and entirely customisable, giving the user the ability to implement any analysis they wish. Although programming languages can seem daunting to the uninitiated, it's far easier to learn than many immunologists may think. Rather than seeking to become an expert programmer, an understanding of the main concepts is more than enough to conduct your own bespoke analyses when coupled with a sound mathematical and statistical understanding. Our new book focusses on the practical aspects of data science, providing sufficient theoretical background without delving into all of the details of each of the methods presented. Introductory chapters are presented alongside the analysis of a publicly available data set, allowing the reader to have practical hands-on experience when learning about important concepts in statistics, machine learning and programming. Topics include: - How to build a predictive model How to visualise high-dimensional data Basics of programming in Python and R What techniques exist to cluster data Which statistics test to use/why/when What is dimension reduction; when and how to use it Once these fundamental topics have been covered, a number of case studies are presented, along with the underlying data, accompanying code and full explanations on topics such as automated, data-driven flow cytometry, building predictive models of disease using gene expression profiling and analysing high throughput sequencing data.
Author: Niclas Thomas Publisher: ISBN: 9781985665675 Category : Languages : en Pages : 158
Book Description
Data science is a complex subject, but nevertheless one that can be made accessible to all through clear, intuitive explanations and worked examples. Existing software that forms the backbone of an immunologist's analytical toolkit (such as FlowJo and Prism) are expensive, inflexible and promotes a narrow mindset when it comes to analysing your data. On the other hand, the Python and R programming languages are open source, free and entirely customisable, giving the user the ability to implement any analysis they wish. Although programming languages can seem daunting to the uninitiated, it's far easier to learn than many immunologists may think. Rather than seeking to become an expert programmer, an understanding of the main concepts is more than enough to conduct your own bespoke analyses when coupled with a sound mathematical and statistical understanding. Our new book focusses on the practical aspects of data science, providing sufficient theoretical background without delving into all of the details of each of the methods presented. Introductory chapters are presented alongside the analysis of a publicly available data set, allowing the reader to have practical hands-on experience when learning about important concepts in statistics, machine learning and programming. Topics include: - How to build a predictive model How to visualise high-dimensional data Basics of programming in Python and R What techniques exist to cluster data Which statistics test to use/why/when What is dimension reduction; when and how to use it Once these fundamental topics have been covered, a number of case studies are presented, along with the underlying data, accompanying code and full explanations on topics such as automated, data-driven flow cytometry, building predictive models of disease using gene expression profiling and analysing high throughput sequencing data.
Author: Gordon MacPherson Publisher: John Wiley & Sons ISBN: 352767313X Category : Science Languages : en Pages : 373
Book Description
Knapp und präzise erklärt dieses einführende Lehrbuch der Immunologie die Funktion des Immunsystems anhand sorgfältig ausgewählter Beispiele aus der klinischen Praxis und dem Experiment. Von Büchern mit ähnlichem Themenspektrum unterscheidet es sich durch den klar evidenzbasierten Ansatz. Die Autoren -- ein erfahrener Dozent und ein angesehener Forscher -- regen dabei stets zur kritischen Reflexion des gelernten Stoffs an. Based on examples using clinical and experimental data, this concise introductory textbook provides an insight into the immune system, prompting readers to ask critical questions in order to further advance our understanding. Website: www.wiley-vch.de/home/immunology
Author: Z. Harris Publisher: Springer Science & Business Media ISBN: 9789027725165 Category : Philosophy Languages : en Pages : 622
Book Description
DOES DISCOURSE HAVE A 'STRUCTURE'? HARRIS'S REVOLUTION IN LINGUISTICS As a freshman back in 1947 I discovered that within the various academic divisions and subdivisions of the University of Pennsylvania there existed a something (it was not a Department, but a piece of the Anthropology Department) called 'Linguistic Analysis'. I was an untalented but enthusiastic student of Greek and a slightly more talented student of German, as well as the son of a translator, so the idea of 'Linguistic Analysis' attracted me, sight unseen, and I signed up for a course. It turned out that 'Linguistic Analysis' was essentially a graduate program - I and another undergraduate called Noam Chomsky were the only two undergraduates who took courses in Linguistic Analysis - and also that it was essentially a one-man show: a professor named Zellig Harris taught all the courses with the aid of graduate Teaching Fellows (and possibly - I am not sure - one Assistant Professor). The technicalities of Linguistic Analysis were formidable, and I never did master them all. But the powerful intellect and personality of Zellig Harris drew me like a lodestone, and, although I majored in Philosophy, I took every course there was to take in Linguistic Analysis from then until my gradua tion. What 'Linguistics' was like before Zellig Harris is something not many people care to remember today.
Author: Zoltan A. Nagy Publisher: Academic Press ISBN: 0124201083 Category : Medical Languages : en Pages : 357
Book Description
A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. Contains the history of major breakthroughs in immunology featured with authenticity and insider details Gives an insight into personal aspects of the players in the history of immunology Enables the reader to recognize and select data of heuristic value which elucidate important facets of the immune system Provides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune system Gives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author
Author: Massoud Mahmoudi Publisher: ISBN: 9780940780897 Category : Allergy and immunology Languages : en Pages : 0
Book Description
A brief overview of the basic science and clinical aspects of immunology. The basic science section is a clear presentation of innate and adaptive immunity, immune cells, antibodies and antigens, and other components of the immune system and their interactions. The clinical section clarifies hypersensitivity, autoimmunity, immunodeficiency, common diagnostic tests, vaccination, transplantation, and tumor immunology.
Author: Josep Bassaganya-Riera Publisher: Academic Press ISBN: 0128037156 Category : Medical Languages : en Pages : 212
Book Description
Computational Immunology: Models and Tools encompasses the methodological framework and application of cutting-edge tools and techniques to study immunological processes at a systems level, along with the concept of multi-scale modeling. The book's emphasis is on selected cases studies and application of the most updated technologies in computational modeling, discussing topics such as computational modeling and its usage in immunological research, bioinformatics infrastructure, ODE based modeling, agent based modeling, and high performance computing, data analytics, and multiscale modeling. There are also modeling exercises using recent tools and models which lead the readers to a thorough comprehension and applicability. The book is a valuable resource for immunologists, computational biologists, bioinformaticians, biotechnologists, and computer scientists, as well as all those who wish to broaden their knowledge in systems modeling. Offers case studies with different levels of complexity Provides a detailed view on cutting-edge tools for modeling that are useful to experimentalists with limited computational skills Explores the usage of simulation for hypothesis generation, helping the reader to understand the most valuable points on experimental setting
Author: Paul-Pierre Pastoret Publisher: Academic Press ISBN: 0080533760 Category : Medical Languages : en Pages : 698
Book Description
This unique book provides a comprehensive and comparative guide to the immune systems of major vertebrate species, including domestic and wild animals of veterinary or medical interest, fish and amphibia. Data in this essential reference work has been compiled by world-renowned editors and an international group of authors. For each species, the information is presented in a structured 'user-friendly' format allowing easy cross reference and comparison between the various species. This book will be considered the definitive reference work on vertebrate immunology and will be essential for scientists and professionals working in Immunology, Vaccinology or with Animal Models, for students of Veterinary or Human Medicine, Biology and researchers in Comparative Medicine and Physiology. Each section, devoted to a major animal group covers: Lymphoid organs and their anatomical disposition Leukocytes and their markers Leukocyte traffic and associated molecules Cytokines T cell receptors Immunoglobulins MHC antigens Ontogeny of the immune system Passive transfer of immunity Neonatal immune responses Non-specific immunity Complement system Mucosal immunity Immunodeficiencies Tumours of the immune system Autoimmunity
Author: Arthur M. Silverstein Publisher: Elsevier ISBN: 0080925839 Category : Medical Languages : en Pages : 445
Book Description
This is a professional-level intellectual history of the development of immunology from about 1720 to about 1970. Beginning with the work and insights of the early immunologists in the 18th century, Silverstein traces the development of the major ideas which have formed immunology down to the maturation of the discipline in the decade following the Second World War. Emphasis is placed on the philosophic and sociologic climate of the scientific milieu in which immunology has developed, providing a background to the broad culture of the discipline. A professional-level intellectual history of the development of immunology from about 1720 to 1970, with emphasis placed on the social climate of the scientific milieu in which modern immunology evolved Written by an author very well known both as a historian of medical science and for his substantial research contributions to the immunopathology of the eye The only complete history of immunology available
Author: Rafael Fernandez-Botran Publisher: CRC Press ISBN: 1420039237 Category : Medical Languages : en Pages : 177
Book Description
Immunologists as well investigators in other disciplines may often use protocols involving the isolation, cultures and characterization of different types of leukocytes. Advanced Methods in Cellular Immunology is a collection of techniques in an easy-to-use format. Each chapter provides readers with related program information, a step-by-step de
Author: Jayajit Das Publisher: CRC Press ISBN: 1498717411 Category : Science Languages : en Pages : 355
Book Description
"Taken together, the body of information contained in this book provides readers with a bird’s-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together." –Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined. Readers from immunology, quantitative biology, and applied physics will benefit from the following: Fundamental principles of computational immunology and modern quantitative methods for studying immune response at the single molecule, cellular, organism, and population levels. An overview of basic concepts in modeling and data analysis. Coverage of topics where mechanistic modeling has contributed substantially to current understanding. Discussion of genetic diversity of the immune system, cell signaling in the immune system, immune response at the cell population scale, and ecology of host-pathogen interactions.
Author: Niclas Thomas
Author: Niclas Thomas
Author: Gordon MacPherson
Author: Z. Harris
Author: Zoltan A. Nagy
Author: Massoud Mahmoudi
Author: Josep Bassaganya-Riera
Author: Paul-Pierre Pastoret
Author: Arthur M. Silverstein
Author: Rafael Fernandez-Botran
Author: Jayajit Das