Current Topics in Malaria PDF Download

Author: Alfonso J. Rodriguez-Morales
Publisher: Intechopen
ISBN: 9535127896
Category : Medical
Languages : en
Pages : 508

View

Book Description
Malaria causes hundreds of thousands of human deaths every year, and the World Health Assembly has made it a priority. To help eliminate this disease, there is a pressing need for the development and implementation of new strategies to improve the prevention and treatment, due in part to antimalarial drug resistances. This chapter focuses on two strategies to inactivate the malaria parasite in blood, which are photodynamic therapy (PDT) and inhibition of hemozoin formation. The PDT strategy permits either a control of the proliferation of mosquito larvae to develop some photolarvicides for the prevention or a photoinactivation of the malaria parasite in red blood cells (RBCs) to minimize infection transmission by transfusion. The inhibition of hemozoin formation strategy is used for the development of new antimalarial drug by understanding its formation mechanism.

Author: Hugo D. Lujan
Publisher: Springer Science & Business Media
ISBN: 3709101980
Category : Medical
Languages : en
Pages : 413

View

Book Description
Giardia is a relatively simple eukaryotic microbe, causing acute and chronic diarrhea which has been used as a model to understand complex biological processes occurring in eukaryotic cells. Further, due to its parasitic lifestyle, Giardia is an excellent system for the study of the mechanisms of adaptation and cell differentiation from the perspectives of molecular and cell biology. This book presents a comprehensive review of the current state of knowledge regarding all aspects of Giardia’s biology, including epidemiology, cell and molecular biology, genetics, pathogenesis, diagnostics, and clinical treatment. It was written by internationally renowned authors, the leading researchers in the field including several chapters with techniques and resources available for the study of this microorganism. Questions that need to be addressed to fully understand the molecular mechanisms of the parasite as well as the cause of its pathology are presented. Furthermore, Giardia’s biology is compared with that of other parasites in relation to their complexity. This volume is an indispensable resource for researchers working with this parasite. It is a “must” for libraries and the bookshelves of everyone interested in the biology of parasites and early-branching eukaryotes.

Author:
Publisher: Academic Press
ISBN: 0128204753
Category : Medical
Languages : en
Pages : 296

View

Book Description
Giardia and Giardiasis Volume 107-Part B, in the Advances in Parasitology series, is dedicated to aspects of cytoskeletal structure of this parasite with an emphasis on insights of new components and their function in trophozoites. Further, microtubule function and its critical involvement in motility, attachment, mitosis and cell division as well as in transitions between developmental stages are reviewed. Also a comprehensive revision in the progress of tools to explore and understand the functional biology of Giardia, its coding and non-coding genes, features and cellular and molecular biology is contained in this volume. Additionally, an exciting perspective on the interactions between Giardia and intestinal epithelial cell by reviewing transcriptomic and proteomic investigations is included along with a state-of-the art of the understanding pathophysiology of giardiasis and of how Giardia can cause post-infectious and extra-intestinal complications. A complete review of current knowledge including commonly prescribed drugs, causes of therapeutic fails, drug resistance mechanisms, strategies for the discovery of new agents for alternative drug therapies is covered.

Author: Guadalupe Ortega-Pierres
Publisher: Academic Press
ISBN: 9780128177204
Category : Medical
Languages : en
Pages : 0

View

Book Description
Giardia and Giardiasis, Volume 106 in Advances in Parasitology series includes in the first part aspects of molecular and cellular biology of Giardia and the role of particular molecules or molecular groups in essential functions and/or trafficking in the parasite. These approaches are with the aim to explore how this parasite adapts to an ever-changing environment both within and outside of the host animal. Subsequently a comprehensive description of virulence factors secreted by Giardia, are reviewed on their cytotoxic mechanisms and roles in the pathophysiology of giardiasis, and also a description on the potential of these secreted molecules as targets for drugs is included. In the context of the immuno-pathogenesis of giardiasis a review on the data and information on innate and adaptive immunity to Giardia, is included as well as a discussion on how improved knowledge of immunity is advancing our understanding of the pathogenesis and clinical outcomes of giardiasis. The final part of this volume includes a review of the epidemiology of giardiasis in a veterinary context using molecular tools together with a discussion of the current status of the species and assemblages of Giardia, and issues surrounding the assignment of host specificity and the zoonotic potential using current molecular markers.

Author: Anjan Debnath
Publisher: Frontiers Media SA
ISBN: 2889452484
Category :
Languages : en
Pages : 179

View

Book Description
One of the top four contributors to the global burden of disease is diarrheal infections. Intestinal parasites are major causes of morbidity and mortality associated with diarrheal diseases in both the developed and developing world. Amebiasis is responsible for 50 million cases of invasive disease and 70,000 deaths annually in the world. Giardiasis has an estimated worldwide prevalence of 280 million cases annually. In developed countries, Giardia lamblia infects about 2% of adults and 6-8% of children. The prevalence of G. lamblia infection is generally higher in developing countries, ranging from 3% to 90%. Furthermore, giardial infections contribute substantially to the 2.5 million annual deaths from diarrheal disease. In Asia, Africa, and Latin America, about 500,000 new giardiasis cases are reported each year. Cryptosporidium accounts for 20% and 9% of diarrheal episodes in children in developing and developed countries, respectively. Infection with Cryptosporidium can be chronic and especially debilitating in immunosuppressed individuals and malnourished children. A recent study to measure disease burden, based on disability-adjusted life years (DALYs), found that cryptosporidiosis and amebiasis produce about 10.6 million DALYs. This exceeds the DALYs of any helminth infection currently being targeted by the World Health Organization for preventive chemotherapy. Because of its link with poverty, Giardia and Cryptosporidium were included in the WHO Neglected Diseases Initiative in 2004. E. histolytica, G. lamblia, and C. parvum have been listed by the National Institutes of Health (NIH) as category B priority biodefense pathogens due to low infectious dose and potential for dissemination through compromised food and water supplies in the United States. Despite the prevalence of amebiasis, giardiasis, and cryptosporidiosis there are no vaccines or prophylactic drugs. The first-line drugs for invasive amebiasis and giardiasis chemotherapy are nitroimidazoles, with the prototype, metronidazole, being the most common drug used worldwide. Metronidazole has been shown to be both mutagenic in a microbiological system and carcinogenic to rodents, and frequently causes gastrointestinal side effects. In spite of the efficacy of nitroimidazole drugs, treatment failures in giardiasis occur in up to 20% of cases. Clinical resistance of G. lamblia to metronidazole is proven and cross resistance is a concern with all commonly used antigiardial drugs. Nitazoxanide, the only FDA-approved drug for the treatment of cryptosporidiosis, is effective in the treatment of immunocompetent patients and partially effective for immunosuppressed patients. Therefore, it is critical to search for more effective drugs to treat amebiasis, giardiasis, and cryptosporidiosis. This Research Topic for Frontiers in Microbiology will explore the recent progress in drug development for parasitic diarrheal diseases. This includes an understanding of drug resistance mechanisms. We would also welcome submissions on the drug development for other diarrheal parasites. We hope that this research topic will include a comprehensive survey of various attempts by the parasitology research community to create effective drugs for these diseases.

Author: Edward T Ryan
Publisher: Elsevier Health Sciences
ISBN: 0323625509
Category : Medical
Languages : en
Pages : 1265

View

Book Description
New emerging diseases, new diagnostic modalities for resource-poor settings, new vaccine schedules ... all significant, recent developments in the fast-changing field of tropical medicine. Hunter's Tropical Medicine and Emerging Infectious Diseases, 10th Edition, keeps you up to date with everything from infectious diseases and environmental issues through poisoning and toxicology, animal injuries, and nutritional and micronutrient deficiencies that result from traveling to tropical or subtropical regions. This comprehensive resource provides authoritative clinical guidance, useful statistics, and chapters covering organs, skills, and services, as well as traditional pathogen-based content. You'll get a full understanding of how to recognize and treat these unique health issues, no matter how widespread or difficult to control. - Includes important updates on malaria, leishmaniasis, tuberculosis and HIV, as well as coverage of Ebola, Zika virus, Chikungunya, and other emerging pathogens. - Provides new vaccine schedules and information on implementation. - Features five all-new chapters: Neglected Tropical Diseases: Public Health Control Programs and Mass Drug Administration; Health System and Health Care Delivery; Zika; Medical Entomology; and Vector Control – as well as 250 new images throughout. - Presents the common characteristics and methods of transmission for each tropical disease, as well as the applicable diagnosis, treatment, control, and disease prevention techniques. - Contains skills-based chapters such as dentistry, neonatal pediatrics and ICMI, and surgery in the tropics, and service-based chapters such as transfusion in resource-poor settings, microbiology, and imaging. - Discusses maladies such as delusional parasitosis that are often seen in returning travelers, including those making international adoptions, transplant patients, medical tourists, and more. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.

Author: Centers for Disease Control and Prevention CDC
Publisher: Oxford University Press
ISBN: 0190628634
Category : Medical
Languages : en
Pages : 705

View

Book Description
THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

Author: David Carmena
Publisher: Mdpi AG
ISBN: 9783036530789
Category : Science
Languages : en
Pages : 216

View

Book Description
The enteric protozoans Cryptosporidium spp. and Giardia duodenalis are the most common diarrhoea-causing protozoan parasites worldwide. Cryptosporidium spp. is a leading cause of diarrhoea morbidity and mortality in children younger than 5 years of age in poor-resource settings in sub-Saharan Africa and South Asia. Although infection by G. duodenalis is rarely a fatal condition, giardiasis is commonly associated with childhood growth faltering and cognitive impairment. Because of their significant socioeconomic impact, particularly in low-income countries, giardiasis and cryptosporidiosis joined the "Neglected Disease Initiative" launched by the World Health Organization in 2004. Both Cryptosporidium spp. and G. duodenalis are ubiquitous in the environment and can infect a wide range of hosts with different specificities, meaning that humans may acquire the infection via waterborne, foodborne, or zoonotic transmission. Recent advances in detection and molecular epidemiology have indicated that certain species/genotypes of Cryptosporidium and G. duodenalis have an expanded range of suitable hosts, suggesting that their transmission pathways are more intricate than previously thought, challenging our current notion of host specificities. Therefore, there is a clear need for more studies aiming at investigatingthat aim to investigate the frequency and molecular diversity of these parasites in humans, production and companion animals, and wildlife species. This information would be extremely useful to elucidate the transmission dynamics of cryptosporidiosis and giardiasis, and to investigate the exact contribution of zoonotic events to human infections.

Author: Alfonso J. Rodriguez-Morales
Publisher: BoD – Books on Demand
ISBN: 1789848245
Category : Medical
Languages : en
Pages : 179

View

Book Description
Tropical emerging diseases pose a significant risk for the circulation of old and new pathogens in areas previously unknown, also implying the possibility of new morbidities and mortalities and new consequences for naïve populations. Globalization, migration and travel are key factors for tropical diseases, and represent the need for integration of tropical medicine, travel medicine and epidemiology in the understanding of such complex situations. Neglected tropical diseases such as leprosy or Chagas disease, arboviral diseases, HIV, Ebola, and arenaviral infections are just a few examples. This book tries to update significant epidemiological and clinical research in many aspects with a multinational perspective.

Author: Guadalupe Ortega-Pierres
Publisher: CABI
ISBN: 1845933915
Category : Medical
Languages : en
Pages : 518

View

Book Description
Giardia and Cryptosporidium are both parasites of considerable global interest due to the gastrointestinal problems these organisms can cause in humans as well as domestic and wild animals. Despite its long history as the causative agent of giardiasis, the clinical and zoonotic significance of Giardia infections in humans and animals is only beginning to emerge with the application of molecular tools. Less is known about Cryptosporidium and studies seek to understand the impact of infection in livestock and other animals, its epidemiology and zoonotic significance. Presenting a comprehensive overview of recent research this book draws on the experience of experts in all fields of Giardia and Cryptosporidium research.