Current and Emerging Therapies in Pancreatic Cancer PDF Download

Author: Tanios Bekaii-Saab
Publisher: Springer
ISBN: 3319582569
Category : Medical
Languages : en
Pages : 381

View

Book Description
This book provides a comprehensive, state-of-the art review of current and new therapies in treating pancreatic cancer. In addition to discussing the current landscape for treating various stages of pancreatic cancer, the text highlights several standard and emerging approaches, with a particular emphasis on novel endoscopic, surgical, chemotherapeutic, radiotherapeutic, targeted, and immunotherapeutic strategies. The volume also features concepts on the potential economic effects associated with the development and implementation of new treatments in pancreatic cancer. Written by experts from a variety of integrative disciplines, Current and Emerging Therapies in Pancreatic Cancer is a valuable resource for oncologists, gastroenterologists, surgeons, and other professionals who treat and manage patients with pancreatic cancer.

Author: Amy Sterling Casil
Publisher: The Rosen Publishing Group, Inc
ISBN: 1435850084
Category : Juvenile Nonfiction
Languages : en
Pages : 66

View

Book Description
Explains what pancreatic cancer is, how the disease is detected and treated, and describes research being done to prevent and cure the disease.

Author: Douglas B. Evans
Publisher: Springer Science & Business Media
ISBN: 0387216006
Category : Medical
Languages : en
Pages : 413

View

Book Description
The MD Anderson Solid Tumor Oncology series presents cutting-edge surgical treatment and medical therapy for specific sites. This volume, Pancreatic Cancer, addresses epidemiology and molecular biology, inherited syndromes, staging, surgical techniques, multimodality therapy, and emerging therapies. The individual chapters focus on narrow, specific topics to produce a reference work of value to those interested in pancreatic cancer from a clinical and translational research perspective. A must-have for surgical oncologists and general surgeons.

Author:
Publisher: Elsevier
ISBN: 0443133557
Category : Medical
Languages : en
Pages : 392

View

Book Description
Pancreatic Cancer: Basic Mechanisms and Therapies, Volume 159 in the Advances in Cancer Research, presents the latest release in this ongoing, well-regarded serial with invaluable information on the exciting and fast-moving field of cancer research. Pancreatic cancer (PC) is the third leading cause of cancer-related deaths in the United States. Greater than 90% PCs are Pancreatic ductal adenocarcinomas (PDAC) which have a dismal estimated 5-year overall survival of only 11%. PDAC is predicted to become the second leading cause of mortality in the United States by 2030. In the clinic, the PDAC patients often present with incurable disease at the time of first diagnosis. This cancer is particularly lethal because of its propensity to spread quickly to distant organs including the lymphatic system. PDAC metastasis occurs shortly after tumor initiation and is caused by a complex interaction between autonomous tumor cells and cellular elements of the tumor microenvironment. Although PDAC remains a challenging disease to treat and a leading cause of cancer-related deaths, progress is being made in disease etiology and pathogenesis, and intensive research is focused on developing optimal treatment approaches for patients. Considering the continuous progress being made in understanding PDAC pathogenesis and designing new therapies, it was considered timely to develop an up-to-date thematic issue of Advances in Cancer Research (ACR) focused on PDAC. In this thematic issue, we have included ten review articles by experts that cover cancer disparities, PDAC pathobiology, the roles of the tumor microenvironment, tumor heterogeneity, PC stem cells, genetic and signaling events critical for PDAC pathogenesis, Immunotherapy and chemoresistance in PDAC, and different PDAC mouse models. This special issue highlights recent research progress in PDAC, which bridges the gap between basic and clinical research. The recent overview of Racial Disparities in Pancreatic Cancer Clinical Trials; Overview the evolution of in vivo models for PDAC Up-to-date discussion of diverse genetic and molecular signaling changes in PDAC; Role of tumor heterogeneity in therapy resistance in PDAC; Chemoresistance in PDAC and how to overcome this challenge; Current and emerging approaches and strategies for advancing targeted therapy and immunotherapy for PDAC New insights into the role of epithelial-to-mesenchymal transition, tumor microenvironment (TME) and interactions of TME with cancer stem cells in PDAC pathogenesis, progression and therapeutic resistance

Author: Manoop S. Bhutani
Publisher: Springer Nature
ISBN: 3031057244
Category : Medical
Languages : en
Pages : 394

View

Book Description
This book provides a comprehensive, state-of-the-art overview of pancreatic cancer. The text presents new data about risk factors and genetic predisposition for pancreatic cancer, highlights current screening strategies and preliminary results, and reviews diagnosis and staging of pancreatic cancer, with a focus on imaging evaluations, laparoscopy, endoscopic ultrasound-guided biopsies, and biomarkers. The book also spotlights emerging paradigms in pancreatic cancer management, such as minimally invasive surgical approaches and emerging radiation approaches, and provides valuable insight into the role of nutrition and early integration of supportive/palliative care for pancreatic cancer patients. Written by experts in the field, Pancreatic Cancer: A Multidisciplinary Approach is an invaluable resource for physicians and researchers with an interest in pancreatic cancer.

Author: Born Incredible
Publisher: Shuttle Systems
ISBN: 1776846583
Category : Health & Fitness
Languages : en
Pages : 234

View

Book Description
"Pancreatic Cancer: A Comprehensive Resource for Patients and Families" is an essential guide for anyone affected by this challenging disease. This meticulously crafted book offers an in-depth look into the world of pancreatic cancer, providing valuable insights and support for patients, their families, and caregivers.Structured into a number of thoughtfully organized chapters, this book covers a wide range of critical topics:Begin your journey with an understanding of Pancreatic Cancer, exploring its biology, types, and the risk factors involved.Learn about Symptoms and Early Detection to recognize signs and the importance of timely diagnosis.The Diagnosis of Pancreatic Cancer chapter navigates through the complex processes of imaging, biopsies, and the significance of staging.Delve into Treatment Options, discussing the nuances of surgery, radiation, chemotherapy, and newer therapies like immunotherapy.Managing Side Effects and Complications offers practical advice on dealing with treatment's physical and emotional impacts.Advanced and Metastatic Pancreatic Cancer addresses the challenges of more severe cases and focuses on palliative care.Stay informed about the latest advancements with a chapter on Clinical Trials and Research.The Role of Genetics in pancreatic cancer is demystified, providing insights into familial risks and genetic testing.Emphasize Prevention and healthy living through chapters on Lifestyle and Prevention.Find solace and support with our comprehensive guide on Support for Patients and Families, discussing emotional coping strategies and caregiver roles.Navigate the often-overlooked Legal and Financial Issues that arise with long-term illness.End-of-Life Care provides sensitive and practical advice for making difficult decisions.Survivors and Life After Treatment focuses on the challenges and triumphs post-treatment.Finally, look towards the Future of Pancreatic Cancer Treatment, exploring emerging therapies and the promise of personalized medicine."Packed with information and practical advice, 'Pancreatic Cancer: A Comprehensive Resource for Patients and Families' is more than just a book; it's a companion in your journey, offering hope, understanding, and guidance through every stage of this illness. This book is an invaluable tool for anyone touched by pancreatic cancer, whether you are a patient, a loved one, or a medical professional seeking to provide the best care and support."

Author: Shubham Pant
Publisher: Springer Nature
ISBN: 303138623X
Category : Medical
Languages : en
Pages : 197

View

Book Description
Pancreatic cancer is a challenging and complex disease characterized by a dense fibrotic stroma and an immunosuppressive tumor microenvironment. Until recently, there were no predictive biomarkers to personalize selection of targeted or biologic therapies as a part of standard of care treatment. Moreover, the regulatory immune population of cells creates a “cold”, non-immunogenic tumor that is resistant to immunotherapies including checkpoint inhibitors. However, in the last few years, there has been substantial progress in our understanding of the role mutations in the pathogenesis of disease leading to increased adoption of germline and next generation sequencing to identify mutations and fusions to optimize selection of therapies and select patients for clinical trials of targeted agents. This book provides a comprehensive, global overview on therapy for pancreatic cancer, exploring approved therapies and focusing on the “Next” in drug development including molecularly targeted therapy and efforts at “Drugging the Undruggable”: the KRAS mutation. It also addresses efforts at targeting the inhospitable stroma to improve drug delivery to the tumor cells, incorporating ct DNA (liquid biopsies) in the care of patients and recent advances in immunotherapy. Pancreatic Cancer: Current Therapeutics and Future Directions will illuminate these challenges, review existing therapeutics, and highlight current and future efforts to improve outcomes in this devastating disease. Useful to physicians, fellows, medical students, residents, physician assistants, nurse practitioners, pharmaceutical companies and researchers interested in pancreatic cancer, it will first explain management of localized disease including resectability and adjuvant and neoadjuvant therapies. Targeted therapies including molecular, immunotherapy, stroma and role of ctDNA or “liquid biopsies” will be addressed. Finally, the book will explore the important role of pain management, diet and exercise in improving outcomes in pancreatic cancer.

Author: National Academies Of Sciences Engineeri
Publisher: National Academies Press
ISBN: 9780309684002
Category : Medical
Languages : en
Pages :

View

Book Description
Cancer is the second leading cause of death among adults in the United States after heart disease. However, improvements in cancer treatment and earlier detection are leading to growing numbers of cancer survivors. As the number of cancer survivors grows, there is increased interest in how cancer and its treatments may affect a person's ability to work, whether the person has maintained employment throughout the treatment or is returning to work at a previous, current, or new place of employment. Cancer-related impairments and resulting functional limitations may or may not lead to disability as defined by the U.S. Social Security Administration (SSA), however, adults surviving cancer who are unable to work because of cancer-related impairments and functional limitations may apply for disability benefits from SSA. At the request of SSA, Diagnosing and Treating Adult Cancers and Associated Impairments provides background information on breast cancer, lung cancer, and selected other cancers to assist SSA in its review of the listing of impairments for disability assessments. This report addresses several specific topics, including determining the latest standards of care as well as new technologies for understanding disease processes, treatment modalities, and the effect of cancer on a person's health and functioning, in order to inform SSA's evaluation of disability claims for adults with cancer.

Author: Stephen Safe
Publisher: Frontiers Media SA
ISBN: 2832548482
Category : Medical
Languages : en
Pages : 103

View

Book Description
Pancreatic cancer is a highly lethal gastrointestinal disease that is becoming one of the leading causes of cancer mortality worldwide. Despite advances in surgery, radiation therapy, immuno-oncology, and therapeutics, the 5-year survival rate for pancreatic cancer patients remains around 12%. The poor prognosis is mainly due to late diagnosis, as pancreatic cancer patients commonly don’t exhibit symptoms until an advanced stage that is beyond surgical resection. Currently, the main treatments for patients with advanced pancreatic cancer are chemotherapy, radiotherapy, and most recent clinical trials incorporate immunotherapy.

Author: Susan Tsai
Publisher: Springer
ISBN: 3319989448
Category : Medical
Languages : en
Pages : 205

View

Book Description
This book is designed to present a comprehensive understanding for the rationale of neoadjuvant treatment sequencing for localized pancreatic cancer and to focus on accurate clinical staging and stage-specific treatment sequencing. Sections address important aspects of clinical management of localized pancreatic cancer from diagnosis to surgery. These areas include initial radiographic staging, management of obstructive jaundice, role of chemotherapy and chemoradiation in neoadjuvant therapy, assessment of treatment response, and operative considerations for complex vascular resections. A brief review of suggested readings addressing the particular topic follows in each section, as well as a summary of clinical “pearls”. Management of Localized Pancreatic Cancer: Current Treatment and Challenges provides a comprehensive resource which clearly defines the principles of neoadjuvant therapy as well as a clinical framework for successful therapy. It serves as a valuable guide to physicians of multiple disciplines who are interested in utilizing neoadjuvant therapy for localized pancreatic cancer.