CpG-DNA-antigen Conjugates PDF Download

Author: Tobias Maurer
Publisher:
ISBN:
Category :
Languages : en
Pages : 160

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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description
Bacterial DNA as well as synthetic singlestranded CpG-DNA oligonucleotides displaying unmethylated CpG motifs activate the vertebrate immune system. Upon engaging toll-like receptor 9 CpG-DNA triggers potent Th1-based immune responses characterized by generation of cytotoxic T lymphocytes (CTL), certain cytokines and antibody subclasses. Here we demonstrate that by covalently linking antigen and CpG-DNA antigen is efficiently directed into intracellular compartments of antigen presenting cells resulting in activation, increased cross-presentation of antigen-derived peptides and thus enhanced induction of antigen-specific CTL responses in vivo. Hence, linked CpG-DNA fulfils a dual role: shutteling antigen-uptake and mediating antigen-specific activation. Since conjugation to stimulatory DNA reduces allergenicity, yet improves immunogenicity of complexed antigens, these conjugates could yield therapeutic potential in vaccine strategies against cancer, allergy or infectious diseases.

Author: Eyal Raz
Publisher: Springer Science & Business Media
ISBN: 1592593054
Category : Science
Languages : en
Pages : 397

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Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).

Author: H. Wagner
Publisher: Springer Science & Business Media
ISBN: 364259672X
Category : Medical
Languages : en
Pages : 249

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Book Description
Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.

Author: Freda K. Stevenson
Publisher:
ISBN:
Category : Antigens
Languages : en
Pages : 292

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Author: Virgil Schijns
Publisher: Elsevier
ISBN: 0080457215
Category : Medical
Languages : en
Pages : 396

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Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. - Contributions from leading international authorities in the field - Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system - Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator

Author: Rosario Pignatello
Publisher: BoD – Books on Demand
ISBN: 9533076615
Category : Science
Languages : en
Pages : 474

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These contribution books collect reviews and original articles from eminent experts working in the interdisciplinary arena of biomaterial development and use. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different synthetic and engineered biomaterials. Contributions were selected not based on a direct market or clinical interest, but on results coming from a very fundamental studies. This too will allow to gain a more general view of what and how the various biomaterials can do and work for, along with the methodologies necessary to design, develop and characterize them, without the restrictions necessary imposed by industrial or profit concerns. Biomaterial constructs and supramolecular assemblies have been studied, for example, as drug and protein carriers, tissue scaffolds, or to manage the interactions between artificial devices and the body. In this volume of the biomaterial series have been gathered in particular reviews and papers focusing on the application of new and known macromolecular compounds to nanotechnology and nanomedicine, along with their chemical and mechanical engineering aimed to fit specific biomedical purposes.

Author: Tina Rich
Publisher: Springer Science & Business Media
ISBN: 0387274456
Category : Science
Languages : en
Pages : 227

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Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. Bassett and Tina Rich Overview n the last few pages of Immunology: The Science of Self-Nonself Discrimination Jan Klein ponders on what he would study if he were to start over in the lab. ^ Dismissing the I antibody, MHC, the T-cell and parasitology, he considers instead the phylogeny of immune reactions, particularly in ancient phyla. As for a favored cell he chooses the macrophage. Describ ing it as a ^^MddchenfUr alles," (all purpose kitchen maid) Klein believed that this immunocyte still had secrets to reveal. Toll-Like Receptor (TLR) biology would prove to be one of these secrets. Analyses of the evolution of these receptors (Tolls and TLRs) have also helped us to rethink immune system phylogeny. In the first part of this chapter the history of the discovery of Toll and TLR biology is described. The evolution of the TLR genes and theories of immune function are covered in later sections. The remainder of this book presents work from nine groups active in the field. In the first chapter, "The Function of Toll-Like Receptors", Zlatko Dembic sets the stage by introducing us to many of the components of the immune system and their relationships vis a vis Toll receptors. Zlatko finishes his chapter with a discussion about current immune system models and contributes his own 'integrity model'. Work from the laboratory of Nicholas Gay follows this in "Structures and Motifs Involved in Toll Signaling".

Author: N. Franklin Adkinson
Publisher:
ISBN:
Category : Health & Fitness
Languages : en
Pages : 1052

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Provides coverage of state-of-the-art basic science as well as guidance on the practical aspects of day-to-day diagnosis and management.

Author: Gerold Schuler
Publisher: CRC Press
ISBN: 9780849356469
Category : Medical
Languages : en
Pages : 336

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Epidermal Langerhans Cells focuses on epidermal Langerhans cells (LCs) and the important role they play in the induction of contact hypersensitivity and graft rejection. This in-depth work discusses how these antigen-presenting cells are modulated by various physicochemical agents (such as UV light) and how they can be infected by the AIDS virus. It also reveals that cytokines mediate their development into potent T cell-stimulatory dendritic cells. This comprehensive review covers important experimental details and methods, and fascinating information on LCs. It also provides an overview of the immune system as it relates to the skin in health and disease. This up-to-date publication is an indispensable resource for all investigative and clinical dermatologists, as well as immunologists interested in antigen-presenting cells.