Author: Louis LasagnaPublisher: W.B. Saunders Company
ISBN:
Category : Medical
Languages : en
Pages : 640
Book Description
Controversies in Therapeutics
Author: Louis LasagnaPublisher: W.B. Saunders Company
ISBN:
Category : Medical
Languages : en
Pages : 640
Book Description
Improving and Accelerating Therapeutic Development for Nervous System Disorders
Author: Institute of MedicinePublisher: National Academies Press
ISBN: 0309292492
Category : Medical
Languages : en
Pages : 107
Book Description
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Controversies in Thrombolytic Therapy
Author: Symposium Controversies in Thrombolytic Therapy (1996, Orlando, Fla.)Publisher:
ISBN:
Category : Fibrinolytic agents
Languages : en
Pages : 27
Book Description
Proton Therapy Physics
Author: Harald PaganettiPublisher: CRC Press
ISBN: 1439836450
Category : Medical
Languages : en
Pages : 691
Book Description
Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.
Controversies in Dermatologic Drug Therapy
Author: Stephen E. WolvertonMarijuana As Medicine?
Author: Institute of MedicinePublisher: National Academies Press
ISBN: 0309065313
Category : Medical
Languages : en
Pages : 216
Book Description
Some people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms? Would it be breaking the law to turn to marijuana as a medication? There are few sources of objective, scientifically sound advice for people in this situation. Most books about marijuana and medicine attempt to promote the views of advocates or opponents. To fill the gap between these extremes, authors Alison Mack and Janet Joy have extracted critical findings from a recent Institute of Medicine study on this important issue, interpreting them for a general audience. Marijuana As Medicine? provides patientsâ€"as well as the people who care for themâ€"with a foundation for making decisions about their own health care. This empowering volume examines several key points, including: Whether marijuana can relieve a variety of symptoms, including pain, muscle spasticity, nausea, and appetite loss. The dangers of smoking marijuana, as well as the effects of its active chemical components on the immune system and on psychological health. The potential use of marijuana-based medications on symptoms of AIDS, cancer, multiple sclerosis, and several other specific disorders, in comparison with existing treatments. Marijuana As Medicine? introduces readers to the active compounds in marijuana. These include the principal ingredient in Marinol, a legal medication. The authors also discuss the prospects for developing other drugs derived from marijuana's active ingredients. In addition to providing an up-to-date review of the science behind the medical marijuana debate, Mack and Joy also answer common questions about the legal status of marijuana, explaining the conflict between state and federal law regarding its medical use. Intended primarily as an aid to patients and caregivers, this book objectively presents critical information so that it can be used to make responsible health care decisions. Marijuana As Medicine? will also be a valuable resource for policymakers, health care providers, patient counselors, medical faculty and studentsâ€"in short, anyone who wants to learn more about this important issue.
Controversies in COX-2 inhibitor therapy
Author: Controversial Therapies for Developmental Disabilities
Author: John W. JacobsonPublisher: CRC Press
ISBN: 1135636117
Category : Education
Languages : en
Pages : 528
Book Description
What approaches to early intervention, education, therapy, and remediation really help those with mental retardation and developmental disabilities improve their functioning and adaptation? This book brings together leading behavioral scientists and practitioners to focus light on the major controversies surrounding such questions.
Controversies in Intensive Care Medicine
Author: Ralf KuhlenPublisher: MWV
ISBN: 3939069612
Category : Medical
Languages : en
Pages : 534
Book Description
In recent years, many clinical interventions in intensive care medicine have been based on clear scientific evidence. However, at least as many clinical interventions still remain the subject of controversy, either due to a lack of rigorous data or due to the existence of conflicting data. In this book, these controversies are discussed by experts of international renown in their respective fields. The goal is twofold: To provide us with a balanced and unbiased presentation of the subject, explaining the different 'schools of thought' relevant to the controversy; To summarise the data with a clinically useful and valid recommendation for our practice. Virtually all fields of intensive care medicine are covered in over 50 chapters dealing with controversies over treatment options in acute illness states, organising and providing care for acutely ill patients, as well as how to answer ethical questions arising in critical care medicine every day.
Author: William F. Rayburn