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Contribution à l'étude des mécanismes moléculaires de l'instabilité de l'hémoglobine humaine

Contribution à l'étude des mécanismes moléculaires de l'instabilité de l'hémoglobine humaine PDF Author: Josiane Bardakdjian
Publisher:
ISBN:
Category :
Languages : fr
Pages : 356

Book Description
L'ETUDE DES HEMOGLOBINES ANORMALES, PRESENTEES DANS CE MEMOIRE, A PERMIS DE PRECISER CERTAINS MECANISMES MOLECULAIRES IMPLIQUES DANS LA STABILITE DU TETRAMERE. ELLE A CONFIRME L'IMPORTANCE, POUR LA STABILITE, DE L'INTEGRITE DE LA POCHE DE L'HEME OU POUR LA PREMIERE FOIS, ON A PU APPRECIER LES EFFETS D'UNE DELETION DANS L'ANGLE CD (HEMOGLOBINE BRUXELLES). ELLE A CONTRIBUE A METTRE EN EVIDENCE LE ROLE PREPONDERANT DES CONTACTS ENTRE LES HELICES B ET G (HEMOGLOBINE HENRI MONDOR) ET ENTRE LES HELICES H ET F (HEMOGLOBINE OLMSTED) DE LA CHAINE BETA. ELLE A CONFIRME LE ROLE DU CONTACT ALPHA1 BETA1 (HEMOGLOBINE CAMPERDOWN). ELLE A RENFORCE LA NOTION QUE LE GLYCOCOLLE DESTABILISE LES STRUCTURES EN HELICE ALPHA (HEMOGLOBINE DHONBURI). ELLE A ILLUSTRE L'EFFET SUR LA STABILITE DE LA DELETION D'UNE DES BASES CODANT POUR UN RESIDU SITUE EN FIN DE CHAINE ET ENTRAINANT U DECALAGE DU CADRE DE LECTURE (HEMOGLOBINE SAVERNE). ELLE A MONTRE A NOUVEAU QUE DANS LE CAS DES HEMOGLOBINES TRES INSTABLES, DIFFICILES A IDENTIFIER DANS LE GLOBULE ROUGE, LES TECHNIQUES DE SYNTHESE DE CHAINES POURRAIENT SUGGERER L'EXISTENCE D'UNE HEMOGLOBINE ANORMALE (HEMOGLOBINE OLMSTED)

Contribution à l'étude des mécanismes moléculaires de l'instabilité de l'hémoglobine humaine

Contribution à l'étude des mécanismes moléculaires de l'instabilité de l'hémoglobine humaine PDF Author: Josiane Bardakdjian
Publisher:
ISBN:
Category :
Languages : fr
Pages : 356

Book Description
L'ETUDE DES HEMOGLOBINES ANORMALES, PRESENTEES DANS CE MEMOIRE, A PERMIS DE PRECISER CERTAINS MECANISMES MOLECULAIRES IMPLIQUES DANS LA STABILITE DU TETRAMERE. ELLE A CONFIRME L'IMPORTANCE, POUR LA STABILITE, DE L'INTEGRITE DE LA POCHE DE L'HEME OU POUR LA PREMIERE FOIS, ON A PU APPRECIER LES EFFETS D'UNE DELETION DANS L'ANGLE CD (HEMOGLOBINE BRUXELLES). ELLE A CONTRIBUE A METTRE EN EVIDENCE LE ROLE PREPONDERANT DES CONTACTS ENTRE LES HELICES B ET G (HEMOGLOBINE HENRI MONDOR) ET ENTRE LES HELICES H ET F (HEMOGLOBINE OLMSTED) DE LA CHAINE BETA. ELLE A CONFIRME LE ROLE DU CONTACT ALPHA1 BETA1 (HEMOGLOBINE CAMPERDOWN). ELLE A RENFORCE LA NOTION QUE LE GLYCOCOLLE DESTABILISE LES STRUCTURES EN HELICE ALPHA (HEMOGLOBINE DHONBURI). ELLE A ILLUSTRE L'EFFET SUR LA STABILITE DE LA DELETION D'UNE DES BASES CODANT POUR UN RESIDU SITUE EN FIN DE CHAINE ET ENTRAINANT U DECALAGE DU CADRE DE LECTURE (HEMOGLOBINE SAVERNE). ELLE A MONTRE A NOUVEAU QUE DANS LE CAS DES HEMOGLOBINES TRES INSTABLES, DIFFICILES A IDENTIFIER DANS LE GLOBULE ROUGE, LES TECHNIQUES DE SYNTHESE DE CHAINES POURRAIENT SUGGERER L'EXISTENCE D'UNE HEMOGLOBINE ANORMALE (HEMOGLOBINE OLMSTED)

The World Problem of Salmonellosis

The World Problem of Salmonellosis PDF Author: E. van Oye
Publisher:
ISBN: 9789401198431
Category :
Languages : en
Pages : 612

Book Description


Global Burden of Disease and Risk Factors

Global Burden of Disease and Risk Factors PDF Author: Alan D. Lopez
Publisher: World Bank Publications
ISBN: 0821362631
Category : Medical
Languages : en
Pages : 511

Book Description
Strategic health planning, the cornerstone of initiatives designed to achieve health improvement goals around the world, requires an understanding of the comparative burden of diseases and injuries, their corresponding risk factors and the likely effects of invervention options. The Global Burden of Disease framework, originally published in 1990, has been widely adopted as the preferred method for health accounting and has become the standard to guide the setting of health research priorities. This publication sets out an updated assessment of the situation, with an analysis of trends observed since 1990 and a chapter on the sensitivity of GBD estimates to various sources of uncertainty in methods and data.

What is the Code of Conduct for Responsible Fisheries?

What is the Code of Conduct for Responsible Fisheries? PDF Author: Food and Agriculture Organization of the United Nations
Publisher: Food & Agriculture Org.
ISBN: 9789251045411
Category : Business & Economics
Languages : en
Pages : 20

Book Description
The actual Code of conduct is also available (1996) (ISBN 9251038341).

Multidisciplinary approaches to food and foodways in the medieval Eastern Mediterranean

Multidisciplinary approaches to food and foodways in the medieval Eastern Mediterranean PDF Author: Sylvie Yona Waksman
Publisher:
ISBN: 9782356680709
Category :
Languages : en
Pages :

Book Description


Clinical Chronopharmacology

Clinical Chronopharmacology PDF Author: Alain Reinberg
Publisher: CRC Press
ISBN:
Category : Design
Languages : en
Pages : 268

Book Description
Periodical and predictable changes in biological susceptibility and response to a large variety of chemical agents, including drugs and food, have been documented since the early 1970s. This book provides a survey of clinically-documented research in chronopharmacology.

Food Chemistry Research Developments

Food Chemistry Research Developments PDF Author: Konstantinos N. Papadopoulos
Publisher: Nova Publishers
ISBN: 9781604562620
Category : Science
Languages : en
Pages : 320

Book Description
Food chemistry is the study of chemical processes and interactions of all biological and non-biological components of foods. The biological substances include such items as meat, poultry, lettuce, beer, and milk as examples. It is similar to biochemistry in its main components such as carbohydrates, lipids, and protein, but it also includes areas such as water, vitamins, minerals, enzymes, food additives, flavours, and colours. This discipline also encompasses how products change under certain food processing techniques and ways either to enhance or to prevent them from happening. An example of enhancing a process would be to encourage fermentation of dairy products with lactic acid; an example of a preventing process would be stopping the Maillard reaction on the surface of freshly cut Red Delicious apples whether by hand or mechanical methods. This book presents the recent research from around the world in this field.

An Introduction to Differential Manifolds

An Introduction to Differential Manifolds PDF Author: Jacques Lafontaine
Publisher: Springer
ISBN: 3319207350
Category : Mathematics
Languages : en
Pages : 408

Book Description
This book is an introduction to differential manifolds. It gives solid preliminaries for more advanced topics: Riemannian manifolds, differential topology, Lie theory. It presupposes little background: the reader is only expected to master basic differential calculus, and a little point-set topology. The book covers the main topics of differential geometry: manifolds, tangent space, vector fields, differential forms, Lie groups, and a few more sophisticated topics such as de Rham cohomology, degree theory and the Gauss-Bonnet theorem for surfaces. Its ambition is to give solid foundations. In particular, the introduction of “abstract” notions such as manifolds or differential forms is motivated via questions and examples from mathematics or theoretical physics. More than 150 exercises, some of them easy and classical, some others more sophisticated, will help the beginner as well as the more expert reader. Solutions are provided for most of them. The book should be of interest to various readers: undergraduate and graduate students for a first contact to differential manifolds, mathematicians from other fields and physicists who wish to acquire some feeling about this beautiful theory. The original French text Introduction aux variétés différentielles has been a best-seller in its category in France for many years. Jacques Lafontaine was successively assistant Professor at Paris Diderot University and Professor at the University of Montpellier, where he is presently emeritus. His main research interests are Riemannian and pseudo-Riemannian geometry, including some aspects of mathematical relativity. Besides his personal research articles, he was involved in several textbooks and research monographs.

Minimum competence in scientific English

Minimum competence in scientific English PDF Author: Sue Blattes
Publisher: L'Editeur : EDP Sciences
ISBN: 9782868835888
Category : English language
Languages : fr
Pages : 264

Book Description
Cet ouvrage, devenu célèbre sous son sigle MCSE, a déjà été utilisé par plus de 50 000 étudiants, chercheurs, professionnels. L'objectif est de lire et écrire des textes en anglais scientifique avec facilité et pertinence. L'ouvrage est conçu pour que l'apprenant devienne un véritable utilisateur de l'anglais. La méthode originale repose sur l'analyse des fonctions et structures nécessaires : measurement, frequency, comparison, modification, link words, time, cause and consequence, hypothesis, modality, purpose and process, impersonal forms, compound nouns and adjectives. Dans chaque unit, des tests d'auto-évaluation permettent de se situer et de construire son parcours de formation, d'abord en définissant ses objectifs à l'aide des key points et du lexis, puis, de façon plus personnalisée, en puisant dans les examples in context, checkpoints (back to basics, word web), web search, FAQs... MCSE est l'outil de base d'une méthode qui comprend aussi d'autres outils dans la même collection (Listening Comprehension for Scientiflc English et Speaking Skills in Scientitic English). L'ouvrage est destiné à tout apprenant de niveau baccalauréat qui désire acquérir une réelle compétence dans l'écriture et la lecture de textes en anglais scientifique.

Revue Roumaine de Médecine

Revue Roumaine de Médecine PDF Author:
Publisher:
ISBN:
Category : Virology
Languages : fr
Pages : 374

Book Description