Creating Continuous Flow PDF Download

Author: Mike Rother
Publisher: Lean Enterprise Institute
ISBN: 0966784332
Category : Business & Economics
Languages : en
Pages : 117

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Book Description
This workbook explains in simple, step-by-step terms how to introduce and sustain lean flows of material and information in pacemaker cells and lines, a prerequisite for achieving a lean value stream.A sight we frequently encounter when touring plants is the relocation of processing steps from departments (process villages) to product-family work cells, but too often these "cells" produce only intermittent and erratic flow. Output gyrates from hour to hour and small piles of inventory accumulate between each operation so that few of the benefits of cellularization are actually being realized; and, if the cell is located upstream from the pacemaker process, none of the benefits may ever reach the customer.This sequel to Learning to See (which focused on plant level operations) provides simple step-by-step instructions for eliminating waste and creating continuous flow at the process level. This isn't a workbook you will read once then relegate to the bookshelf. It's an action guide for managers, engineers, and production associates that you will use to improve flow each and every day.Creating Continuous Flow takes you to the next level in work cell design where you'll achieve even greater cost and lead time savings. You'll learn: where to focus your continuous flow efforts, how to create much more efficient work cells and lines, how to operate a pacemaker process so that a lean value stream is possible, how to sustain the gains, and keep improving.Creating Continuous Flow is the next logical step after Learning to See. The value-stream mapping process defined the pacemaker process and the overall flow of products and information in the plant. The next step is to shift your focus from the plant to the process level by zeroing in on the pacemaker process, which sets the production rhythm for the plant or value stream, and apply the principles of continuous flow.Every production facility has at least one pacemaker process. The pacemaker processes is usually where products take their final form before going to external customers. It’s called the pacemaker because how you operate here determines both how well you can serve the customer and what the demand pattern is like for your upstream supplying processes.How the pacemaker process operates is critically important. A steady and consistently flowing pacemaker places steady and consistent demands on the rest of the value stream. The continuous flow processing that results allows companies to create leaner value streams.[Source : 4e de couv.]

Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309487811
Category : Medical
Languages : en
Pages : 69

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Book Description
On July 30-31, 2018, the National Academies of Sciences, Engineering, and Medicine held a workshop titled Continuous Manufacturing for the Modernization of Pharmaceutical Production. This workshop discussed the business and regulatory concerns associated with adopting continuous manufacturing techniques to produce biologics such as enzymes, monoclonal antibodies, and vaccines. The participants also discussed specific challenges for integration across the manufacturing system, including upstream and downstream processes, analytical techniques, and drug product development. The workshop addressed these challenges broadly across the biologics domain but focused particularly on drug categories of greatest FDA and industrial interest such as monoclonal antibodies and vaccines. This publication summarizes the presentations and discussions from the workshop.

Author: Peter Kleinebudde
Publisher: John Wiley & Sons
ISBN: 1119001323
Category : Science
Languages : en
Pages : 645

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Book Description
A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.

Author: Jez Humble
Publisher: Pearson Education
ISBN: 0321670221
Category : Computers
Languages : en
Pages : 956

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Book Description
Winner of the 2011 Jolt Excellence Award! Getting software released to users is often a painful, risky, and time-consuming process. This groundbreaking new book sets out the principles and technical practices that enable rapid, incremental delivery of high quality, valuable new functionality to users. Through automation of the build, deployment, and testing process, and improved collaboration between developers, testers, and operations, delivery teams can get changes released in a matter of hours— sometimes even minutes–no matter what the size of a project or the complexity of its code base. Jez Humble and David Farley begin by presenting the foundations of a rapid, reliable, low-risk delivery process. Next, they introduce the “deployment pipeline,” an automated process for managing all changes, from check-in to release. Finally, they discuss the “ecosystem” needed to support continuous delivery, from infrastructure, data and configuration management to governance. The authors introduce state-of-the-art techniques, including automated infrastructure management and data migration, and the use of virtualization. For each, they review key issues, identify best practices, and demonstrate how to mitigate risks. Coverage includes • Automating all facets of building, integrating, testing, and deploying software • Implementing deployment pipelines at team and organizational levels • Improving collaboration between developers, testers, and operations • Developing features incrementally on large and distributed teams • Implementing an effective configuration management strategy • Automating acceptance testing, from analysis to implementation • Testing capacity and other non-functional requirements • Implementing continuous deployment and zero-downtime releases • Managing infrastructure, data, components and dependencies • Navigating risk management, compliance, and auditing Whether you’re a developer, systems administrator, tester, or manager, this book will help your organization move from idea to release faster than ever—so you can deliver value to your business rapidly and reliably.

Author: Nada R. Sanders
Publisher: Pearson Education
ISBN: 0133438643
Category : Business & Economics
Languages : en
Pages : 187

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Book Description
To succeed in manufacturing and service operations, managers need both technical and behavioral skills, and know how to apply these skills to transform processes and outputs in a wide variety of operational contexts throughout the supply chain. Now, there's an authoritative and comprehensive guide to best-practice manufacturing and service operations in any organization. Co-authored by a leading expert alongside the Council of Supply Chain Management Professionals (CSCMP), this reference details the planning, organizing, controlling, directing, motivating and coordinating functions used to produce goods or services. It covers long-term strategic decisions such as facility location; mid-term tactical decisions such as setting levels of inventory and labor; and short-term operational decisions such as job assignments. Coverage includes: Basic manufacturing and service operations concepts, purposes, terminology, roles, and goals; types of manufacturing and services; planning processes; inventory and labor requirements; process control; productivity levels, and budget control Key elements, processes, and interactions, including facility, material, and labor requirements planning; scheduling; and continuous process and quality improvement processes, including TQM, ISO, Six Sigma, SPC, Theory of Constraints, FMEA, and 5S Principles/strategies for establishing efficient, effective, and sustainable operations: Manufacturing and services planning and strategies, encompassing facility ownership and location, production, processes, layout, lead capacity, technology, personnel, measurement, compensation, sustainability, and more The key roles and value of technology, including MRP II systems, service systems, ERP systems, and capabilities for supporting manufacturing and service planning, execution, and cost management. Requirements and challenges of global manufacturing and service operations, including manufacturing and outsourcing in Low-Cost Countries (LCCs); logistical difficulties, labor challenges, financial implications, decision processes, contract performance, risk management, and regulation Best practices for assessing performance using standard metrics and frameworks, including KPIs, tradeoff analysis, scorecarding, dashboards, and exception management

Author: Marty Cagan
Publisher: John Wiley & Sons
ISBN: 1119691257
Category : Business & Economics
Languages : en
Pages : 435

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Book Description
"Great teams are comprised of ordinary people that are empowered and inspired. They are empowered to solve hard problems in ways their customers love yet work for their business. They are inspired with ideas and techniques for quickly evaluating those ideas to discover solutions that work: they are valuable, usable, feasible and viable. This book is about the idea and reality of "achieving extraordinary results from ordinary people". Empowered is the companion to Inspired. It addresses the other half of the problem of building tech products?how to get the absolute best work from your product teams. However, the book's message applies much more broadly than just to product teams. Inspired was aimed at product managers. Empowered is aimed at all levels of technology-powered organizations: founders and CEO's, leaders of product, technology and design, and the countless product managers, product designers and engineers that comprise the teams. This book will not just inspire companies to empower their employees but will teach them how. This book will help readers achieve the benefits of truly empowered teams"--

Author: Fernando Muzzio
Publisher: Academic Press
ISBN: 0128134801
Category : Medical
Languages : en
Pages : 444

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Book Description
How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems provides a comprehensive overview on the considerations necessary for the design of continuous pharmaceutical manufacturing processes. The book covers both the theory and design of continuous processing of associated unit operations, along with their characterization and control. In addition, it discusses practical insights and strategies that the editor and chapter authors have learned. Chapters cover Process Analytical Technology (PAT) tools and the application of PAT data to enable distributed process control. With numerous case studies throughout, this valuable guide is ideal for those engaged in, or learning about, continuous processing in pharmaceutical manufacturing. - Discusses the development of strategy blueprints in the design of continuous processes - Shows how to create process flowsheet models from individual unit operation models - Includes a chapter on characterization methods for materials, the use of statistical methods to analyze material property data, and the use of material databases - Covers the evolving regulatory expectations for continuous manufacturing - Provides readers with ways to more effectively navigate these expectations

Author: Ganapathy Subramanian
Publisher: John Wiley & Sons
ISBN: 3527699910
Category : Science
Languages : en
Pages : 697

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Book Description
This is the most comprehensive treatise of this topic available, providing invaluable information on the technological and economic benefits to be gained from implementing continuous processes in the biopharmaceutical industry. Top experts from industry and academia cover the latest technical developments in the field, describing the use of single-use technologies alongside perfusion production platforms and downstream operations. Special emphasis is given to process control and monitoring, including such topics as 'quality by design' and automation. The book is supplemented by case studies that highlight the enormous potential of continuous manufacturing for biopharmaceutical production facilities.

Author: Elaine Stattler
Publisher: John Wiley & Sons
ISBN: 0996729321
Category : Business & Economics
Languages : en
Pages : 565

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Book Description
The essential guide for today’s savvy controllers Today’s controllers are in leadership roles that put them in the unique position to see across all aspects of the operations they support. The Master Guide to Controllers’ Best Practices, Second Edition has been revised and updated to provide controllers with the information they need to successfully monitor their organizations’ internal control environments and offer direction and consultation on internal control issues. In addition, the authors include guidance to help controllers carryout their responsibilities to ensure that all financial accounts are reviewed for reasonableness and are reconciled to supporting transactions, as well as performing asset verification. Comprehensive in scope the book contains the best practices for controllers and: Reveals how to set the right tone within an organization and foster an ethical climate Includes information on risk management, internal controls, and fraud prevention Highlights the IT security controls with the key components of successful governance Examines the crucial role of the controller in corporate compliance and much more The Master Guide to Controllers’ Best Practices should be on the bookshelf of every controller who wants to ensure the well-being of their organization. In addition to their traditional financial role, today’s controllers (no matter how large or small their organization) are increasingly occupying top leadership positions. The revised and updated Second Edition of The Master Guide to Controllers’ Best Practices provides an essential resource for becoming better skilled in such areas as strategic planning, budgeting, risk management, and business intelligence. Drawing on the most recent research on the topic, informative case studies, and tips from finance professionals, the book highlights the most important challenges controllers will face. Written for both new and seasoned controllers, the Guide offers a wide range of effective tools that can be used to improve the skills of strategic planning, budgeting, forecasting, and risk management. The book also contains a resource for selecting the right employees who have the technical knowledge, analytical expertise, and strong people skills that will support the controller’s role within an organization. To advance overall corporate performance, the authors reveal how to successfully align strategy, risk management, and performance management. In addition, the Guide explains what it takes to stay ahead of emerging issues such as healthcare regulations, revenue recognition, globalization, and workforce mobility. As controllers adapt to their new leadership roles and assume more complex responsibilities, The Master Guide to Controllers’ Best Practices offers an authoritative guide to the tools, practices, and ideas controllers need to excel in their profession.

Author: Rajesh Vishnupant Gheware
Publisher: Orange Education Pvt Ltd
ISBN: 8197651167
Category : Computers
Languages : en
Pages : 413

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Book Description
TAGLINE Unlock the Power of Kubernetes: Master Cluster Excellence! KEY FEATURES ● Master Kubernetes from the ground up, covering foundational to expert-level skills. ● Enhance learning with practical examples, clear diagrams, and real-world applications. ● Tailored content to help you confidently pass the CKA certification exam. DESCRIPTION Embark on a journey from beginner to pro with this CKA Certification Guide. Seamlessly blending theory with hands-on practice, this indispensable Kubernetes companion provides clear explanations and real-world scenarios to guide you to success in Kubernetes administration. The book starts by giving a solid understanding of Kubernetes platform and how to confidently set up your clusters with step-by-step instructions. You will dive into Workload Objects to master crucial concepts, then explore Service and Ingress for a deep understanding of networking. Next, it moves to deploy and scale applications, ensuring you're ready for any workload. This book offers the tools needed to design, deploy, and maintain efficient, scalable, and resilient applications in Kubernetes environments. It covers essential topics such as Pods, Deployments, and StatefulSets, along with providing insights into Kubernetes architecture and operations. The advanced section of the book focuses on enhancing your skills with chapters on security and troubleshooting, ensuring you can maintain your clusters effectively and managing microservices with precision. The final section of the book covers focused content and practice exercises to prepare you to ace the CKA certification exam. WHAT WILL YOU LEARN ● Gain the skills to set up, configure, and maintain Kubernetes clusters, ensuring secure and efficient operations. ● Learn how to create, deploy, and manage applications on Kubernetes, including handling updates and scaling. ● Acquire in-depth knowledge of Kubernetes networking and storage, enabling you to design and implement robust solutions. ● Develop expertise in automating application deployments and managing their scaling and availability for optimal performance. ● Build the ability to identify, diagnose, and resolve common Kubernetes problems, ensuring smooth cluster operations. WHO IS THIS BOOK FOR? This book is tailored for IT professionals, including DevOps engineers, system administrators, cloud architects, and Kubernetes enthusiasts, who possess a foundational understanding of containerization concepts and aspire to become proficient in Kubernetes for managing cloud-native applications. If you are a Kubernetes enthusiast looking forward to obtaining your Certified Kubernetes Administrator (CKA) certification, this book will be your indispensable companion. TABLE OF CONTENTS 1. Introduction to Kubernetes 2. Installing Kubernetes 3. Workload Objects – Pod, Deploy, StatefulSet 4. Service and Ingress - Exposing Apps Outside the Cluster 5. Deploy and Scale - Stateless Apps 6. Deployment Strategies - RollingUpdate, Recreate 7. Data Persistence - Local and Cloud 8. Deploy and Scale - StatefulSet 9. Configure Apps for Production Deployment 10. Cluster Database - Backup and Restore 11. Cluster Upgrade – kubeadm 12. CoreDNS 13. Networking - Pod Service and Ingress 14. Kubernetes CNI 15. Kubernetes Security 16. Troubleshooting 17. Kubernetes Production Essentials 18. Microservices Observability 19. Scalable Jenkins on Kubernetes 20. GitOps using ArgoCD and GitHub 21. CKA Exam Mastery Index