Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds PDF Download

Author:
Publisher: Academic Press
ISBN: 0080581188
Category : Science
Languages : en
Pages : 538

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Book Description
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.This special volume of Advances in Pharmacology features a two-color dust jacket.Summarizes the most recent information on: - Xenobiotic conjugation - Drug toxicity, hypersensitivity, and targeting - Chemical carcinogenesis - Glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity - Bioactivation and bioconversion

Author: Andreas Luch
Publisher: Springer Science & Business Media
ISBN: 3764383364
Category : Medical
Languages : en
Pages : 479

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Book Description
Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, this work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health and engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

Author: Emel Arinç
Publisher: Springer Science & Business Media
ISBN: 1461548551
Category : Science
Languages : en
Pages : 297

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Book Description
Proceedings of a NATO ASI held in Antalya, Turkey, August 31 - September 11, 1997

Author: H. Thomas
Publisher: CRC Press
ISBN: 142007458X
Category : Science
Languages : en
Pages : 395

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Book Description
A large number of chemical compunds are constantly being introduced and produced, both to assist and ease modern human life. Among these chemicals, industrial compounds represent a particular fraction of chemicals which are not intended for use in biological systems, but to which humans may be accidently exposed, whether in the workplace, by produc

Author: Stephen C. Mitchell
Publisher: CRC Press
ISBN: 0203362527
Category : Medical
Languages : en
Pages : 236

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Book Description
This text focuses on the biological interactions of sulphur compounds which arise specifically from the presence of the sulphur atom within the molecule. The book opens with introductory chapters on the chemistry and biology of sulphur, before tackling the field by introducing compounds which share a common chemical combination. In general, following a description of the uses and impact upon the biological field, specific chemical group characteristics are discussed together with the biological activity and structure-activity relationships where known. The toxicity of such compounds, their consequences in biochemical and clinical terms, and their mechanisms of biological interaction are then addressed.

Author: P.J. Bert Hakkinen
Publisher: Elsevier
ISBN: 008053466X
Category : Medical
Languages : en
Pages : 953

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Book Description
Information Resources in Toxicology, Third Edition is a sourcebook for anyone who needs to know where to find toxicology information. It provides an up-to-date selective guide to a large variety of sources--books, journals, organizations, audiovisuals, internet and electronic sources, and more. For the Third Edition, the editors have selected, organized, and updated the most relevant information available. New information on grants and other funding opportunities, physical hazards, patent literature, and technical reports have also been added.This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists. - Serves as an all-in-one resource for toxicology information - New edition includes information on publishers, grants and other funding opportunities, physical hazards, patent literature, and technical reports - Updated to include the latest internet and electronic sources, e-mail addresses, etc. - Provides valuable data about the new fields that have emerged within toxicological research; namely, the biochemical, cellular, molecular, and genetic aspects

Author: H.K. Müller-Hermelink
Publisher: Springer Science & Business Media
ISBN: 3642603939
Category : Medical
Languages : en
Pages : 524

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Book Description
Cellular transformation and carcinogenesis are considered a multistep process starting with DNA lesions and progressing through loss of cellular growth control and increase invasive and metastatic properties. This book focuses on the demonstration of important steps in carcinogenesis, ranging from chemical interaction of carcinogens with cellular DNA in experimental tumors and cell lines to the analysis of selected human tumors. Special importance is given to the clarification of mechanisms of DNA lesions caused by chemical carcinogens and UV irradiation. Leading scientists describe in review articles the actual state of the art in their specific fields. The reader is informed of trends and scientific approaches to the recognition of pathogenetic mechanisms and factors in malignant tumors.

Author: Daniel Schlenk
Publisher: CRC Press
ISBN: 135161245X
Category : Medical
Languages : en
Pages : 608

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Book Description
Addressing the numerous gaps in current information, Target Organ Toxicology in Marine and Freshwater Teleosts is an essential resource for researchers and professionals in aquatic toxicology and environmental risk assessment. All the chapters are written by researchers who are internationally recognised for their work in mechanistic aspects of aquatic toxicology. Each chapter focuses on a specific target organ or physiological system and describes how various agents disrupt the normal physiological system and processes. This volume is devoted to specific organs with coverage of the gill, kidney, skin, liver and gut. The companion volume, Systems, provides coverage of toxic effects in the central nervous, immune, neurobehavioural and reproductive systems as well as describing general mechanisms of toxicity.

Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728

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Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author: Wiley-VCH
Publisher: John Wiley & Sons
ISBN: 3527312471
Category : Science
Languages : en
Pages : 1193

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Book Description
The one-stop resource for health protection professionals, environmental scientists and safety engineers. Since the entire 40-volume Ullmann's Encyclopedia is inaccessible to many readers - particularly individuals, smaller companies or institutes - all the information on industrial toxicology, ecotoxicology, process safety as well as occupational health and safety has been condensed into this convenient 2-volume set. Based on the latest online edition of Ullmann's containing articles never been before in print, this ready reference provides practical information on applying the science of toxicology in both the occupational and environmental setting, and explains the fundamentals necessary for an understanding of the effects of chemical hazards on humans and ecosystems. The detailed and meticulously edited articles have been written by renowned experts from industry and academia, and much of the information has been thoroughly revised. Alongside explanations of safety regulations and legal aspects, this set covers food additives, toxic agents as well as medical and therapeutical issues. Top-quality illustrations, clear diagrams and charts combined with an extensive use of tables enhance the presentation and provide a unique level of detail. Deeper insights into any given area of interest is offered by referenced contributions, while rapid access to a particular subject is enhanced by both a keyword and author index.