Computerised Texture and Shape Analysis for Classification of Breast Tumours in Digital Mammograms PDF Download

Author: Qi Guo
Publisher:
ISBN:
Category : Breast
Languages : en
Pages :

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Book Description
Computer-aided diagnosis for detection and classification of breast abnormalities on digital mammograms is an active area of research. In recent years, there have been many research developments in all aspects of the mamography. However, it still faces many challenges. The current detection accuracy of lesions such as mass and architectural distortion is considerably low. This research is focused on computerised texture analysis of mass and architectural distortion, and shape analysis of mass in digital mamograms. In texture analysis, we investigate fractal-based methods in texture charectarisation of mammographic masses and architectural distorition. The individual ability of the different fractal-based features in the task of discriminating between abnormal lesion and normal breast parenchyma tissue are evaluated and compared using statistical analysus and receiver operating charectaristics analysis. The statistical analysis shows significant differences in the fractal-based feature between abnormalities and normal breast parenchyma. Results indicate that fractal-based methods are useful in texture feature extraction of mamographic lesions.

Author: Thanh Cabral
Publisher: Springer Nature
ISBN: 3031016548
Category : Technology & Engineering
Languages : en
Pages : 104

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Book Description
Fractal analysis is useful in digital image processing for the characterization of shape roughness and gray-scale texture or complexity. Breast masses present shape and gray-scale characteristics in mammograms that vary between benign masses and malignant tumors. This book demonstrates the use of fractal analysis to classify breast masses as benign masses or malignant tumors based on the irregularity exhibited in their contours and the gray-scale variability exhibited in their mammographic images. A few different approaches are described to estimate the fractal dimension (FD) of the contour of a mass, including the ruler method, box-counting method, and the power spectral analysis (PSA) method. Procedures are also described for the estimation of the FD of the gray-scale image of a mass using the blanket method and the PSA method. To facilitate comparative analysis of FD as a feature for pattern classification of breast masses, several other shape features and texture measures are described in the book. The shape features described include compactness, spiculation index, fractional concavity, and Fourier factor. The texture measures described are statistical measures derived from the gray-level cooccurrence matrix of the given image. Texture measures reveal properties about the spatial distribution of the gray levels in the given image; therefore, the performance of texture measures may be dependent on the resolution of the image. For this reason, an analysis of the effect of spatial resolution or pixel size on texture measures in the classification of breast masses is presented in the book. The results demonstrated in the book indicate that fractal analysis is more suitable for characterization of the shape than the gray-level variations of breast masses, with area under the receiver operating characteristics of up to 0.93 with a dataset of 111 mammographic images of masses. The methods and results presented in the book are useful for computer-aided diagnosis of breast cancer. Table of Contents: Computer-Aided Diagnosis of Breast Cancer / Detection and Analysis of\newline Breast Masses / Datasets of Images of Breast Masses / Methods for Fractal Analysis / Pattern Classification / Results of Classification of Breast Masses / Concluding Remarks

Author: Thanh M. Cabral
Publisher: Morgan & Claypool Publishers
ISBN: 1627050698
Category : Technology & Engineering
Languages : en
Pages : 120

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Book Description
Fractal analysis is useful in digital image processing for the characterization of shape roughness and gray-scale texture or complexity. Breast masses present shape and gray-scale characteristics in mammograms that vary between benign masses and malignant tumors. This book demonstrates the use of fractal analysis to classify breast masses as benign masses or malignant tumors based on the irregularity exhibited in their contours and the gray-scale variability exhibited in their mammographic images. A few different approaches are described to estimate the fractal dimension (FD) of the contour of a mass, including the ruler method, box-counting method, and the power spectral analysis (PSA) method. Procedures are also described for the estimation of the FD of the gray-scale image of a mass using the blanket method and the PSA method. To facilitate comparative analysis of FD as a feature for pattern classification of breast masses, several other shape features and texture measures are described in the book. The shape features described include compactness, spiculation index, fractional concavity, and Fourier factor. The texture measures described are statistical measures derived from the gray-level cooccurrence matrix of the given image. Texture measures reveal properties about the spatial distribution of the gray levels in the given image; therefore, the performance of texture measures may be dependent on the resolution of the image. For this reason, an analysis of the effect of spatial resolution or pixel size on texture measures in the classification of breast masses is presented in the book. The results demonstrated in the book indicate that fractal analysis is more suitable for characterization of the shape than the gray-level variations of breast masses, with area under the receiver operating characteristics of up to 0.93 with a dataset of 111 mammographic images of masses. The methods and results presented in the book are useful for computer-aided diagnosis of breast cancer. Table of Contents: Computer-Aided Diagnosis of Breast Cancer / Detection and Analysis of\newline Breast Masses / Datasets of Images of Breast Masses / Methods for Fractal Analysis / Pattern Classification / Results of Classification of Breast Masses / Concluding Remarks

Author: Denise Guliato
Publisher: Springer Nature
ISBN: 303179429X
Category : Technology & Engineering
Languages : en
Pages : 75

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Book Description
Malignant tumors due to breast cancer and masses due to benign disease appear in mammograms with different shape characteristics: the former usually have rough, spiculated, or microlobulated contours, whereas the latter commonly have smooth, round, oval, or macrolobulated contours. Features that characterize shape roughness and complexity can assist in distinguishing between malignant tumors and benign masses. In spite of the established importance of shape factors in the analysis of breast tumors and masses, difficulties exist in obtaining accurate and artifact-free boundaries of the related regions from mammograms. Whereas manually drawn contours could contain artifacts related to hand tremor and are subject to intra-observer and inter-observer variations, automatically detected contours could contain noise and inaccuracies due to limitations or errors in the procedures for the detection and segmentation of the related regions. Modeling procedures are desired to eliminate the artifacts in a given contour, while preserving the important and significant details present in the contour. This book presents polygonal modeling methods that reduce the influence of noise and artifacts while preserving the diagnostically relevant features, in particular the spicules and lobulations in the given contours. In order to facilitate the derivation of features that capture the characteristics of shape roughness of contours of breast masses, methods to derive a signature based on the turning angle function obtained from the polygonal model are described. Methods are also described to derive an index of spiculation, an index characterizing the presence of convex regions, an index characterizing the presence of concave regions, an index of convexity, and a measure of fractal dimension from the turning angle function. Results of testing the methods with a set of 111 contours of 65 benign masses and 46 malignant tumors are presented and discussed. It is shown that shape modeling and analysis can lead to classification accuracy in discriminating between benign masses and malignant tumors, in terms of the area under the receiver operating characteristic curve, of up to 0.94. The methods have applications in modeling and analysis of the shape of various types of regions or objects in images, computer vision, computer graphics, and analysis of biomedical images, with particular significance in computer-aided diagnosis of breast cancer. Table of Contents: Analysis of Shape / Polygonal Modeling of Contours / Shape Factors for Pattern Classification / Classification of Breast Masses

Author: Shantanu Banik
Publisher: Springer Nature
ISBN: 3031016564
Category : Technology & Engineering
Languages : en
Pages : 176

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Book Description
Architectural distortion is an important and early sign of breast cancer, but because of its subtlety, it is a common cause of false-negative findings on screening mammograms. Screening mammograms obtained prior to the detection of cancer could contain subtle signs of early stages of breast cancer, in particular, architectural distortion. This book presents image processing and pattern recognition techniques to detect architectural distortion in prior mammograms of interval-cancer cases. The methods are based upon Gabor filters, phase portrait analysis, procedures for the analysis of the angular spread of power, fractal analysis, Laws' texture energy measures derived from geometrically transformed regions of interest (ROIs), and Haralick's texture features. With Gabor filters and phase-portrait analysis, 4,224 ROIs were automatically obtained from 106 prior mammograms of 56 interval-cancer cases, including 301 true-positive ROIs related to architectural distortion, and from 52 mammograms of 13 normal cases. For each ROI, the fractal dimension, the entropy of the angular spread of power, 10 Laws' texture energy measures, and Haralick's 14 texture features were computed. The areas under the receiver operating characteristic (ROC) curves obtained using the features selected by stepwise logistic regression and the leave-one-image-out method are 0.77 with the Bayesian classifier, 0.76 with Fisher linear discriminant analysis, and 0.79 with a neural network classifier. Free-response ROC analysis indicated sensitivities of 0.80 and 0.90 at 5.7 and 8.8 false positives (FPs) per image, respectively, with the Bayesian classifier and the leave-one-image-out method. The present study has demonstrated the ability to detect early signs of breast cancer 15 months ahead of the time of clinical diagnosis, on the average, for interval-cancer cases, with a sensitivity of 0.8 at 5.7 FP/image. The presented computer-aided detection techniques, dedicated to accurate detection and localization of architectural distortion, could lead to efficient detection of early and subtle signs of breast cancer at pre-mass-formation stages. Table of Contents: Introduction / Detection of Early Signs of Breast Cancer / Detection and Analysis of Oriented Patterns / Detection of Potential Sites of Architectural Distortion / Experimental Set Up and Datasets / Feature Selection and Pattern Classification / Analysis of Oriented Patterns Related to Architectural Distortion / Detection of Architectural Distortion in Prior Mammograms / Concluding Remarks

Author: Arianna Mencattini
Publisher: Springer Nature
ISBN: 3031016645
Category : Technology & Engineering
Languages : en
Pages : 166

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Book Description
The identification and interpretation of the signs of breast cancer in mammographic images from screening programs can be very difficult due to the subtle and diversified appearance of breast disease. This book presents new image processing and pattern recognition techniques for computer-aided detection and diagnosis of breast cancer in its various forms. The main goals are: (1) the identification of bilateral asymmetry as an early sign of breast disease which is not detectable by other existing approaches; and (2) the detection and classification of masses and regions of architectural distortion, as benign lesions or malignant tumors, in a unified framework that does not require accurate extraction of the contours of the lesions. The innovative aspects of the work include the design and validation of landmarking algorithms, automatic Tabár masking procedures, and various feature descriptors for quantification of similarity and for contour independent classification of mammographic lesions. Characterization of breast tissue patterns is achieved by means of multidirectional Gabor filters. For the classification tasks, pattern recognition strategies, including Fisher linear discriminant analysis, Bayesian classifiers, support vector machines, and neural networks are applied using automatic selection of features and cross-validation techniques. Computer-aided detection of bilateral asymmetry resulted in accuracy up to 0.94, with sensitivity and specificity of 1 and 0.88, respectively. Computer-aided diagnosis of automatically detected lesions provided sensitivity of detection of malignant tumors in the range of [0.70, 0.81] at a range of falsely detected tumors of [0.82, 3.47] per image. The techniques presented in this work are effective in detecting and characterizing various mammographic signs of breast disease.

Author: K. W. Bowyer
Publisher: World Scientific
ISBN: 9789810215095
Category : Medical
Languages : en
Pages : 312

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Book Description
This book provides a detailed assessment of the state of the art in automated techniques for the analysis of digital mammogram images. Topics covered include a variety of approaches for image processing and pattern recognition aimed at assisting the physician in the task of detecting tumors from evidence in mammogram images. The chapters are written by recognized experts in the field and are revised versions of papers selected from those presented at the “First International Workshop on Mammogram Image Analysis” held in San Jose as part of the 1993 Biomedical Image Processing conference.

Author: Shantanu Banik
Publisher: Morgan & Claypool Publishers
ISBN: 1627050825
Category : Computers
Languages : en
Pages : 196

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Book Description
Architectural distortion is an important and early sign of breast cancer, but because of its subtlety, it is a common cause of false-negative findings on screening mammograms. Screening mammograms obtained prior to the detection of cancer could contain subtle signs of early stages of breast cancer, in particular, architectural distortion. This book presents image processing and pattern recognition techniques to detect architectural distortion in prior mammograms of interval-cancer cases. The methods are based upon Gabor filters, phase portrait analysis, procedures for the analysis of the angular spread of power, fractal analysis, Laws' texture energy measures derived from geometrically transformed regions of interest (ROIs), and Haralick's texture features. With Gabor filters and phase-portrait analysis, 4,224 ROIs were automatically obtained from 106 prior mammograms of 56 interval-cancer cases, including 301 true-positive ROIs related to architectural distortion, and from 52 mammograms of 13 normal cases. For each ROI, the fractal dimension, the entropy of the angular spread of power, 10 Laws' texture energy measures, and Haralick's 14 texture features were computed. The areas under the receiver operating characteristic (ROC) curves obtained using the features selected by stepwise logistic regression and the leave-one-image-out method are 0.77 with the Bayesian classifier, 0.76 with Fisher linear discriminant analysis, and 0.79 with a neural network classifier. Free-response ROC analysis indicated sensitivities of 0.80 and 0.90 at 5.7 and 8.8 false positives (FPs) per image, respectively, with the Bayesian classifier and the leave-one-image-out method. The present study has demonstrated the ability to detect early signs of breast cancer 15 months ahead of the time of clinical diagnosis, on the average, for interval-cancer cases, with a sensitivity of 0.8 at 5.7 FP/image. The presented computer-aided detection techniques, dedicated to accurate detection and localization of architectural distortion, could lead to efficient detection of early and subtle signs of breast cancer at pre-mass-formation stages.

Author: Supriya Salve
Publisher: diplom.de
ISBN: 3960676417
Category : Medical
Languages : en
Pages : 49

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Book Description
Breast cancer is the most common type of cancer in women, which also causes the most cancer deaths among them today. Mammography is the only reliable method to detect breast cancer in the early stage among all diagnostic methods available currently. Breast cancer can occur in both men and women and is defined as an abnormal growth of cells in the breast that multiply uncontrollably. The main factors which cause breast cancer are either hormonal or genetic. Masses are quite subtle, and have many shapes such as circumscribed, speculated or ill-defined. These tumors can be either benign or malignant. Computer-aided methods are powerful tools to assist the medical staff in hospitals and lead to better and more accurate diagnosis. The main objective of this research is to develop a Computer Aided Diagnosis (CAD) system for finding the tumors in the mammographic images and classifying the tumors as benign or malignant. There are five main phases involved in the proposed CAD system: image pre-processing, extraction of features from mammographic images using Gabor Wavelet and Discrete Wavelet Transform (DWT), dimensionality reduction using Principal Component Analysis (PCA) and classification using Support Vector Machine (SVM) classifier.

Author: Pradnya Kulkarni
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 312

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Book Description
"X-ray screening for breast cancer is an important public health initiative in the management of a leading cause of death for women. However, screening is expensive if mammograms are required to be manually assessed by radiologists. Moreover, manual screening is subject to perception and interpretation errors. Computer aided detection/diagnosis (CAD) systems can help radiologists as computer algorithms are good at performing image analysis consistently and repetitively. However, image features that enhance CAD classification accuracies are necessary for CAD systems to be deployed. Many CAD systems have been developed but the specificity and sensitivity is not high; in part because of challenges inherent in identifying effective features to be initially extracted from raw images. Existing feature extraction techniques can be grouped under three main approaches; statistical, spectral and structural. Statistical and spectral techniques provide global image features but often fail to distinguish between local pattern variations within an image. On the other hand, structural approach have given rise to the Bag-of-Visual-Words (BoVW) model, which captures local variations in an image, but typically do not consider spatial relationships between the visual "words". Moreover, statistical features and features based on BoVW models are computationally very expensive. Similarly, structural feature computation methods other than BoVW are also computationally expensive and strongly dependent upon algorithms that can segment an image to localize a region of interest likely to contain the tumour. Thus, classification algorithms using structural features require high resource computers. In order for a radiologist to classify the lesions on low resource computers such as Ipads, Tablets, and Mobile phones, in a remote location, it is necessary to develop computationally inexpensive classification algorithms. Therefore, the overarching aim of this research is to discover a feature extraction/image representation model which can be used to classify mammographic lesions with high accuracy, sensitivity and specificity along with low computational cost. For this purpose a novel feature extraction technique called 'Pixel N-grams' is proposed. The Pixel N-grams approach is inspired from the character N-gram concept in text categorization. Here, N number of consecutive pixel intensities are considered in a particular direction. The image is then represented with the help of histogram of occurrences of the Pixel N-grams in an image. Shape and texture of mammographic lesions play an important role in determining the malignancy of the lesion. It was hypothesized that the Pixel N-grams would be able to distinguish between various textures and shapes. Experiments carried out on benchmark texture databases and binary basic shapes database have demonstrated that the hypothesis was correct. Moreover, the Pixel N-grams were able to distinguish between various shapes irrespective of size and location of shape in an image. The efficacy of the Pixel N-gram technique was tested on mammographic database of primary digital mammograms sourced from a radiological facility in Australia (LakeImaging Pty Ltd) and secondary digital mammograms (benchmark miniMIAS database). A senior radiologist from LakeImaging provided real time de-identified high resolution mammogram images with annotated regions of interests (which were used as groundtruth), and valuable radiological diagnostic knowledge. Two types of classifications were observed on these two datasets. Normal/abnormal classification useful for automated screening and circumscribed/speculation/normal classification useful for automated diagnosis of breast cancer. The classification results on both the mammography datasets using Pixel N-grams were promising. Classification performance (Fscore, sensitivity and specificity) using Pixel N-gram technique was observed to be significantly better than the existing techniques such as intensity histogram, co-occurrence matrix based features and comparable with the BoVW features. Further, Pixel N-gram features are found to be computationally less complex than the co-occurrence matrix based features as well as BoVW features paving the way for mammogram classification on low resource computers. Although, the Pixel N-gram technique was designed for mammographic classification, it could be applied to other image classification applications such as diabetic retinopathy, histopathological image classification, lung tumour detection using CT images, brain tumour detection using MRI images, wound image classification and tooth decay classification using dentistry x-ray images. Further, texture and shape classification is also useful for classification of real world images outside the medical domain. Therefore, the pixel N-gram technique could be extended for applications such as classification of satellite imagery and other object detection tasks." -- Abstract.