Computational Toxicology for Drug Safety and a Sustainable Environment PDF Download

Author: Tahmeena Khan, Saman Raza
Publisher: Bentham Science Publishers
ISBN: 9815196995
Category : Science
Languages : en
Pages : 233

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Book Description
Computational Toxicology for Drug Safety and a Sustainable Environment is a primer on computational techniques in environmental toxicology for scholars. The book presents 9 in-depth chapters authored by expert academicians and scientists aimed to give readers an understanding of how computational models, software and algorithms are being used to predict toxicological profiles of chemical compounds. The book also aims to help academics view toxicological assessment from the lens of sustainability by providing an overview of the recent developments in environmentally-friendly practices. The chapters review the strengths and weaknesses of the existing methodologies, and cover new developments in computational tools to explain how researchers aim to get accurate results. Each chapter features a simple introduction and list of references to benefit a broad range of academic readers. List of topics: 1. Applications of computational toxicology in pharmaceuticals, environmental and industrial practices 2. Verification, validation and sensitivity studies of computational models used in toxicology assessment 3. Computational toxicological approaches for drug profiling and development of online clinical repositories 4. How to neutralize chemicals that kill environment and humans: an application of computational toxicology 5. Adverse environmental impact of pharmaceutical waste and its computational assessment 6. Computational aspects of organochlorine compounds: DFT study and molecular docking calculations 7. In-silico studies of anisole and glyoxylic acid derivatives 8. Computational toxicology studies of chemical compounds released from firecrackers 9. Computational nanotoxicology and its applications Readership Graduate and postgraduate students, academics and researchers in pharmacology, computational biology, toxicology and environmental science programs.

Author: Mousumi Sen
Publisher: John Wiley & Sons
ISBN: 1394212747
Category : Science
Languages : en
Pages : 564

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Book Description
This groundbreaking book offers an in-depth description of sustainable green catalytic processes that have emerged as the means to empower the existing protocols with greener, sustainable, and environmentally benign versions that hold enormous potential in industry and society. Growing worldwide concerns about environmental pollution and global warming have directed the attention of scientists towards approaches for developing sustainable protocols, and the need for employing greener and more sustainable catalytic approaches that are environmentally greener and more eco-friendly than current ones. Green and sustainable catalysts are the one class of catalysts that possess higher selectivity and activity, efficient recovery from the reaction medium, recyclability, cost-effectiveness and are prepared using environmentally benign preparation techniques. The most potent instrument in organic synthesis, and the cornerstone of green chemistry, is catalysis which has broadened the possibilities for organic transformations in the direction of a sustainable future. The catalyst has been playing a vital role, from the improvement of reaction conditions to enhanced selectivity towards the intended product and a decrease in the creation of byproducts. The purpose of this book is to highlight the developments made towards designing new catalysts (homogeneous, heterogeneous, organocatalyst, nanocatalyst, photocatalyst, nanophotocatalyst, biocatalyst, nanobiocatalyst, metal catalyst etc,.) and present the advancements in the field of chemical synthesis using greener catalytic routes with far-reaching applications. The other environmentally friendly method is the enzymatic synthesis of organic molecules, which substitutes safe reagents for those that imitate the biosynthetic route to synthesize the desired organic molecules. With its ability to produce transformations that occasionally enable the reduction of steps in a synthetic route, biophotocatalysis has long been recognized as a green technology and key to creating environmentally friendly and sustainable chemistry. The employment of sustainable green processes on the most crucial reaction steps of the synthetic protocol satisfies contemporary needs for environmentally friendly operations during the creation of valuable chemicals. Readers will find the book: details new catalysts development designs (homo and heterogeneous); presents the advancement of organic synthesis using greener catalytic routes with far-reaching applications; elaborates on preparation techniques for green and sustainable catalysts that possess higher activity, efficient recovery, and cost-effectiveness; discusses how to epitomize a green approach towards the preparation of organic moieties via enzymatic synthesis; analyzes nano-catalysis with green-based reagents and solvents that allow producers to follow the fundamental pillars of the green economy; elucidates green chemistry’s principles and metrics of the chemical’s life cycle and design through disposal. Audience The core audiences for this book include scientists and engineers working in green chemistry, materials science, photocatalysts, biotechnology, nanotechnology, waste minimization, and sustainability. This book is an excellent resource for graduate students, R&D experts, and researchers in academic and industrial fields of chemical synthesis.

Author: Klaus Kümmerer
Publisher: Springer Science & Business Media
ISBN: 3642051995
Category : Technology & Engineering
Languages : en
Pages : 312

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Book Description
Within recent years pharmaceuticals have come into focus as contaminants of the environment (see for example Kümmerer, K. editor: Pharmaceuticals in the Environment). At the same time the issue of sustainable chemistry gained momentum. Bringing both together would result in sustainable pharmacy. Sustainable pharmacy is a totally new issue and approach. It addresses environmental, economical and social aspects of pharmacy. In the present stage the focus will be on environmental issues along the whole lifecycle of a pharmaceutical entity. That is dealing with resources and energy input but also with waste issues for example during the synthesis and production of an active pharmaceutical ingredient. Furthermore, it would also look on the compounds themselves and will aim to improve the degradability of the compounds after their use in the environment to reduce the environmental risk caused by pharmaceuticals in the environment. Another issue is the people using pharmaceuticals such as pharmacists, medical doctors and patients. How can they contribute to more efficient use of pharmaceuticals with less environmental burden and less risk for drinking water. The book "Sustainable Pharmacy" will address all these issues and will be the first one dealing with this important topic.

Author: Alexandra Maertens
Publisher: Royal Society of Chemistry
ISBN: 1839164409
Category : Science
Languages : en
Pages : 225

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Book Description
Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

Author: Mohd Abdul Ahad
Publisher: Springer Nature
ISBN: 3030510700
Category : Technology & Engineering
Languages : en
Pages : 176

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Book Description
This book provides insights into recent trends and innovation of technologies aiming to provide sustainable and energy efficient computing. The authors discuss approaches to provide solutions to real life societal issues and problems using sustainable and energy efficient computing approaches. The book gathers research and state of the art reviews on solutions for societal benefits by using sustainable approaches of computing. The book also intends to provide use-cases for certain real life societal problems. The book can be used by researchers of similar areas, technologists, environmentalists, educationists, research scholars and UG/PG Students as well.

Author: Emily A. Peterson
Publisher: Royal Society of Chemistry
ISBN: 1849739617
Category : Medical
Languages : en
Pages : 338

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Book Description
The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate. Edited by experts who have pioneered green chemistry efforts within their own institutions, this book provides a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches for greatest return on investment. The Editors have taken a comprehensive approach to the topic covering the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Currently employed as well as emerging techniques for performing greener drug discovery chemistry are addressed as well as cutting-edge topics like biologics discovery. Moreover, important surrounding issues such as intellectual property are included. This book will serve as a practical guide for both academic and industrial chemists who work across the breadth of the drug discovery discipline. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309109922
Category : Nature
Languages : en
Pages : 217

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Book Description
Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Author: Shrikaant Kulkarni
Publisher: Springer Nature
ISBN: 9819725968
Category :
Languages : en
Pages : 376

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Book Description

Author: Matthew Hull
Publisher: William Andrew
ISBN: 0128135891
Category : Medical
Languages : en
Pages : 582

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Book Description
Nanotechnology Environmental Health and Safety tackles – in depth and in breadth – the complex and evolving issues pertaining to nanotechnology's environmental health and safety (EHS). The chapters are authored by leaders in their respective fields, providing thorough analysis of their research areas. The diverse spectrum of topics include nanotechnology EHS issues, financial implications, foreseeable risks including exposure, dosage and hazards, and the implications of occupational hygiene precautions and consumer protections. The book includes real-world case studies, wherever practical, to illustrate specific issues and scenarios encountered by stakeholders positioned on the front-lines of nanotechnology-enabled industries. These case studies will appeal to, and resonate with, laboratory scientists, business leaders, regulators, service providers, and postgraduate researchers. - Reviews toxicological studies and industrial initiatives, supported by numerous case studies - Covers new generation of nanoparticles and significantly expands on existing material from second edition - Only edited volume to collect research on the regulatory and risk implications of a wide array of industrial, environmental and consumer nanomaterials

Author:
Publisher: John Wiley & Sons
ISBN: 3527688439
Category : Science
Languages : en
Pages : 564

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Book Description
The shift towards being as environmentally-friendly as possible has resulted in the need for this important reference on the topic of designing safer chemicals. Edited by the leading international experts in the field, this volume covers such topics as toxicity, reducing hazards and biochemical pesticides. An essential resource for anyone wishing to gain an understanding of the world of green chemistry, as well as for chemists, environmental agencies and chemical engineers.