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Author: Kimberly J. McCabe Publisher: Springer Nature ISBN: 3031051645 Category : Computers Languages : en Pages : 117
Book Description
This open access volume compiles student reports from the 2021 Simula Summer School in Computational Physiology. Interested readers will find herein a number of modern approaches to modeling excitable tissue. This should provide a framework for tools available to model subcellular and tissue-level physiology across scales and scientific questions. In June through August of 2021, Simula held the seventh annual Summer School in Computational Physiology in collaboration with the University of Oslo (UiO) and the University of California, San Diego (UCSD). The course focuses on modeling excitable tissues, with a special interest in cardiac physiology and neuroscience. The majority of the school consists of group research projects conducted by Masters and PhD students from around the world, and advised by scientists at Simula, UiO and UCSD. Each group then produced a report that addreses a specific problem of importance in physiology and presents a succinct summary of the findings. Reports may not necessarily represent new scientific results; rather, they can reproduce or supplement earlier computational studies or experimental findings. Reports from eight of the summer projects are included as separate chapters. The fields represented include cardiac geometry definition (Chapter 1), electrophysiology and pharmacology (Chapters 2–5), fluid mechanics in blood vessels (Chapter 6), cardiac calcium handling and mechanics (Chapter 7), and machine learning in cardiac electrophysiology (Chapter 8).
Author: Kimberly J. McCabe Publisher: Springer Nature ISBN: 3031051645 Category : Computers Languages : en Pages : 117
Book Description
This open access volume compiles student reports from the 2021 Simula Summer School in Computational Physiology. Interested readers will find herein a number of modern approaches to modeling excitable tissue. This should provide a framework for tools available to model subcellular and tissue-level physiology across scales and scientific questions. In June through August of 2021, Simula held the seventh annual Summer School in Computational Physiology in collaboration with the University of Oslo (UiO) and the University of California, San Diego (UCSD). The course focuses on modeling excitable tissues, with a special interest in cardiac physiology and neuroscience. The majority of the school consists of group research projects conducted by Masters and PhD students from around the world, and advised by scientists at Simula, UiO and UCSD. Each group then produced a report that addreses a specific problem of importance in physiology and presents a succinct summary of the findings. Reports may not necessarily represent new scientific results; rather, they can reproduce or supplement earlier computational studies or experimental findings. Reports from eight of the summer projects are included as separate chapters. The fields represented include cardiac geometry definition (Chapter 1), electrophysiology and pharmacology (Chapters 2–5), fluid mechanics in blood vessels (Chapter 6), cardiac calcium handling and mechanics (Chapter 7), and machine learning in cardiac electrophysiology (Chapter 8).
Author: Kimberly Joan McCabe Publisher: Springer Nature ISBN: 3031531450 Category : Physiology Languages : en Pages : 120
Book Description
This open access volume compiles student reports from the 2023 Simula Summer School in Computational Physiology. The reports provide an overview of some tools available to model physiology in excitable tissues across scales and scientific questions. In 2023, Simula held the ninth annual Summer School in Computational Physiology in collaboration with the University of Oslo (UiO) and the University of California, San Diego (UCSD). Each year, the course focuses on modeling excitable tissues, with a special interest in cardiac physiology and neuroscience. Group research projects conducted by graduate students from around the world result in reports addressing problems of physiological importance. Reports may not necessarily represent new scientific results; rather, they can reproduce or supplement earlier studies. Reports from seven of the summer projects are included as separate chapters. The topics represented include multiscale mechanics, electrophysiology, pharmacology, and machine learning. This is an open access book.
Author: Taishin Nomura Publisher: Springer Science & Business Media ISBN: 4431538801 Category : Technology & Engineering Languages : en Pages : 230
Book Description
The challenge for the biosciences in the twenty-first century is to integrate genome sequencing information into a better understanding of biology, physiology, and human pathology. Such attempts at integration are moving the world toward a new generation of bioscience and bioengineering, where biological, physiological, and pathological information from humans and other living animals can be quantitatively described in silico across multiple scales of time and size and through diverse hierarchies of organization — from molecules to cells and organs, to individuals. To "harness" such complexity, international communities of integrative bioscientists and bioengineers aim to establish frameworks and information infrastructures for describing biological structures and physiological functions on multiple scales of time and space. This textbook includes a public platform to describe physiological functions using mathematical equations and guides the reader to perform mathematical modeling and computer simulations, to combine existing models as well as to create new models. Accessible to biologists, physiologists, and students of the sciences, with illustrative details provided when necessary, this book seeks to achieve a systematic way of harnessing biological complexity. Sharing the databases among communities worldwide will help to find comprehensive answers to all the important questions.
Author: L. Fedina Publisher: Elsevier ISBN: 1483190226 Category : Science Languages : en Pages : 352
Book Description
Mathematical and Computational Methods in Physiology discusses the importance of quantitative description of physiological phenomena and for quantitative comparison of experimental data. An article explains the homeostasis of the body with a focus on the controlling aspects. This section evaluates the concepts of modern physiology and biocybernetics. The canal-ocular reflex and the otolith-ocular reflex in man stimulates eye rotations compensatory for head angular and linear displacements. The book enumerates some modelling and simulation to observe the visual-vestibular interaction during angular and linear body acceleration. A section on the determination of cardiovascular control is given. The text reviews the mathematical models of the biological age of the rat. A numerical simulation of water transport in epithelial junctions is explained comprehensively. A chapter analyzing the computer simulation of drug-receptor interaction is presented. The book will provide useful information to zoologists, doctors, ophthalmologists, students and researchers in the field of medicine.
Author: Stephen M Baylor Publisher: Independently Published ISBN: 9781661705145 Category : Languages : en Pages : 468
Book Description
This book presents classical and modern topics in cell physiology, with a focus on the function of nerve, muscle, and secretory cells. The laws of diffusion, electricity, and mass action are explained and applied to elucidate the mechanisms by which cells establish a resting membrane potential, achieve osmotic balance, generate action potentials, initiate secretion, and control muscle contraction. The book is experimentally-grounded but also introduces students to Python, a modern, easy-to-learn programming language with powerful scientific and graphical capabilities. Python programs are used throughout the book to illustrate important physiological principles and results. These programs, the explanatory text, and the exercises at the end of each chapter provide a unique framework for the exploration of cell physiology at a quantitative and mechanistic level.
Author: Jerry J. Batzel Publisher: Springer ISBN: 3642328822 Category : Mathematics Languages : en Pages : 270
Book Description
This volume synthesizes theoretical and practical aspects of both the mathematical and life science viewpoints needed for modeling of the cardiovascular-respiratory system specifically and physiological systems generally. Theoretical points include model design, model complexity and validation in the light of available data, as well as control theory approaches to feedback delay and Kalman filter applications to parameter identification. State of the art approaches using parameter sensitivity are discussed for enhancing model identifiability through joint analysis of model structure and data. Practical examples illustrate model development at various levels of complexity based on given physiological information. The sensitivity-based approaches for examining model identifiability are illustrated by means of specific modeling examples. The themes presented address the current problem of patient-specific model adaptation in the clinical setting, where data is typically limited.
Author: Shangbin Chen Publisher: Springer Nature ISBN: 9813340339 Category : Medical Languages : en Pages : 246
Book Description
Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics
Author: Kimberly J. McCabe Publisher: Springer Nature ISBN: 3031253744 Category : Computers Languages : en Pages : 118
Book Description
This open access volume compiles student reports from the 2022 Simula Summer School in Computational Physiology. The reports provide an overview of some tools available to model physiology in excitable tissues across scales and scientific questions. In 2022, Simula held the eighth annual Summer School in Computational Physiology in collaboration with the University of Oslo (UiO) and the University of California, San Diego (UCSD). Each year, the course focuses on modeling excitable tissues, with a special interest in cardiac physiology and neuroscience. Group research projects conducted by graduate students from around the world result in reports addressing problems of physiological importance. Reports may not necessarily represent new scientific results; rather, they can reproduce or supplement earlier studies. Reports from seven of the summer projects are included as separate chapters. The topics represented include multiscale mechanics, electrophysiology, pharmacology, and machine learning.
Author: Kimberly J. McCabe
Author: Kimberly J. McCabe
Author: Kimberly Joan McCabe
Author: Taishin Nomura
Author: L. Fedina
Author: Stephen M Baylor
Author: Jerry J. Batzel
Author: L. Fedina
Author: Shangbin Chen
Author: Kimberly J. McCabe
Author: Julius Guccione