Author: William E Schiesser
Publisher: World Scientific Publishing Company
ISBN: 9813207477
Category : Technology & Engineering
Languages : en
Pages : 172
Book Description
The mathematical model presented in this book, based on partial differential equations (PDEs) describing attractant-repellent chemotaxis, is offered for a quantitative analysis of neurodegenerative disease (ND), e.g., Alzheimer's disease (AD). The model is a representation of basic phenomena (mechanisms) for diffusive transport and biochemical kinetics that provides the spatiotemporal distribution of components which could explain the evolution of ND, and is offered with the intended purpose of providing a small step toward the understanding, and possible treatment of ND.The format and emphasis of the presentation is based on the following elements:In other words, a methodology for numerical PDE modeling is presented that is flexible, open ended and readily implemented on modest computers. If the reader is interested in an alternate model, it might possibly be implemented by: (1) modifying and/or extending the current model (for example, by adding terms to the PDEs or adding additional PDEs), or (2) using the reported routines as a prototype for the model of interest.These suggestions illustrate an important feature of computer-based modeling, that is, the readily available procedure of numerically experimenting with a model. The current model is offered as only a first step toward the resolution of this urgent medical problem.
Computational Chemotaxis Models For Neurodegenerative Disease
Author: William E Schiesser
Publisher: World Scientific Publishing Company
ISBN: 9813207477
Category : Technology & Engineering
Languages : en
Pages : 172
Book Description
The mathematical model presented in this book, based on partial differential equations (PDEs) describing attractant-repellent chemotaxis, is offered for a quantitative analysis of neurodegenerative disease (ND), e.g., Alzheimer's disease (AD). The model is a representation of basic phenomena (mechanisms) for diffusive transport and biochemical kinetics that provides the spatiotemporal distribution of components which could explain the evolution of ND, and is offered with the intended purpose of providing a small step toward the understanding, and possible treatment of ND.The format and emphasis of the presentation is based on the following elements:In other words, a methodology for numerical PDE modeling is presented that is flexible, open ended and readily implemented on modest computers. If the reader is interested in an alternate model, it might possibly be implemented by: (1) modifying and/or extending the current model (for example, by adding terms to the PDEs or adding additional PDEs), or (2) using the reported routines as a prototype for the model of interest.These suggestions illustrate an important feature of computer-based modeling, that is, the readily available procedure of numerically experimenting with a model. The current model is offered as only a first step toward the resolution of this urgent medical problem.
Publisher: World Scientific Publishing Company
ISBN: 9813207477
Category : Technology & Engineering
Languages : en
Pages : 172
Book Description
The mathematical model presented in this book, based on partial differential equations (PDEs) describing attractant-repellent chemotaxis, is offered for a quantitative analysis of neurodegenerative disease (ND), e.g., Alzheimer's disease (AD). The model is a representation of basic phenomena (mechanisms) for diffusive transport and biochemical kinetics that provides the spatiotemporal distribution of components which could explain the evolution of ND, and is offered with the intended purpose of providing a small step toward the understanding, and possible treatment of ND.The format and emphasis of the presentation is based on the following elements:In other words, a methodology for numerical PDE modeling is presented that is flexible, open ended and readily implemented on modest computers. If the reader is interested in an alternate model, it might possibly be implemented by: (1) modifying and/or extending the current model (for example, by adding terms to the PDEs or adding additional PDEs), or (2) using the reported routines as a prototype for the model of interest.These suggestions illustrate an important feature of computer-based modeling, that is, the readily available procedure of numerically experimenting with a model. The current model is offered as only a first step toward the resolution of this urgent medical problem.
Computational Chemotaxis Models for Neurodegenerative Disease
Author: W. E. Schiesser
Publisher:
ISBN: 9789813207462
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN: 9789813207462
Category :
Languages : en
Pages :
Book Description
Handbook of Computational Neurodegeneration
Author: Panagiotis Vlamos
Publisher: Springer Nature
ISBN: 3319759221
Category : Medical
Languages : en
Pages : 1031
Book Description
The Handbook of Computational Neurodegeneration provides a comprehensive overview of the field and thus bridges the gap between standard textbooks of research on neurodegeneration and dispersed publications for specialists that have a narrowed focus on computational methods to study this complicated process. The handbook reviews the central issues and methodological approaches related to the field for which the reader pursues a thorough overview. It also conveys more advanced knowledge, thus serving both as an introductory text and as a starting point for an in-depth study of a specific area, as well as a quick reference source for the expert by reflecting the state of the art and future prospects. The book includes topics that are usually missing in standard textbooks and that are only marginally represented in the specific literature. The broad scope of this handbook is reflected by five major parts that facilitate an integration of computational concepts, methods and applications in the study of neurodegeneration. Each part is intended to stand on its own, giving an overview of the topic and the most important problems and approaches, which are supported by examples, practical applications, and proposed methodologies. The basic concepts and knowledge, standard procedures and methods are presented, as well as recent advances and new perspectives.
Publisher: Springer Nature
ISBN: 3319759221
Category : Medical
Languages : en
Pages : 1031
Book Description
The Handbook of Computational Neurodegeneration provides a comprehensive overview of the field and thus bridges the gap between standard textbooks of research on neurodegeneration and dispersed publications for specialists that have a narrowed focus on computational methods to study this complicated process. The handbook reviews the central issues and methodological approaches related to the field for which the reader pursues a thorough overview. It also conveys more advanced knowledge, thus serving both as an introductory text and as a starting point for an in-depth study of a specific area, as well as a quick reference source for the expert by reflecting the state of the art and future prospects. The book includes topics that are usually missing in standard textbooks and that are only marginally represented in the specific literature. The broad scope of this handbook is reflected by five major parts that facilitate an integration of computational concepts, methods and applications in the study of neurodegeneration. Each part is intended to stand on its own, giving an overview of the topic and the most important problems and approaches, which are supported by examples, practical applications, and proposed methodologies. The basic concepts and knowledge, standard procedures and methods are presented, as well as recent advances and new perspectives.
Computational Analysis of the Human Eye with Applications
Author: Sumeet Dua
Publisher: World Scientific
ISBN: 9814340294
Category : Technology & Engineering
Languages : en
Pages : 467
Book Description
Advances in semi-automated high-throughput image data collection routines, coupled with a decline in storage costs and an increase in high-performance computing solutions have led to an exponential surge in data collected by biomedical scientists and medical practitioners. Interpreting this raw data is a challenging task, and nowhere is this more evident than in the field of opthalmology. The sheer speed at which data on cataracts, diabetic retinopathy, glaucoma and other eye disorders are collected, makes it impossible for the human observer to directly monitor subtle, yet critical details. This book is a novel and well-timed endeavor to present, in an amalgamated format, computational image modeling methods as applied to various extrinsic scientific problems in ophthalmology. It is self-contained and presents a highly comprehensive array of image modeling algorithms and methodologies relevant to ophthalmologic problems. The book is the first of its kind, bringing eye imaging and multi-dimensional hyperspectral imaging and data fusion of the human eye, into focus. The editors are at the top of their fields and bring a strong multidisciplinary synergy to this visionary volume. Their "inverted-pyramid" approach in presenting the content, and focus on core applications, will appeal to students and practitioners in the field.
Publisher: World Scientific
ISBN: 9814340294
Category : Technology & Engineering
Languages : en
Pages : 467
Book Description
Advances in semi-automated high-throughput image data collection routines, coupled with a decline in storage costs and an increase in high-performance computing solutions have led to an exponential surge in data collected by biomedical scientists and medical practitioners. Interpreting this raw data is a challenging task, and nowhere is this more evident than in the field of opthalmology. The sheer speed at which data on cataracts, diabetic retinopathy, glaucoma and other eye disorders are collected, makes it impossible for the human observer to directly monitor subtle, yet critical details. This book is a novel and well-timed endeavor to present, in an amalgamated format, computational image modeling methods as applied to various extrinsic scientific problems in ophthalmology. It is self-contained and presents a highly comprehensive array of image modeling algorithms and methodologies relevant to ophthalmologic problems. The book is the first of its kind, bringing eye imaging and multi-dimensional hyperspectral imaging and data fusion of the human eye, into focus. The editors are at the top of their fields and bring a strong multidisciplinary synergy to this visionary volume. Their "inverted-pyramid" approach in presenting the content, and focus on core applications, will appeal to students and practitioners in the field.
Journal of the Royal Society, Interface
Classical and Computational Solid Mechanics
Author: Yuen-Cheng Fung
Publisher: World Scientific Publishing Company
ISBN: 9789814713641
Category : Technology & Engineering
Languages : en
Pages : 838
Book Description
The second edition provides an update of the recent developments in classical and computational solid mechanics. The structure of the book is also updated to include five new areas: Fundamental Principles of Thermodynamics and Coupled Thermoelastic Constitutive Equations at Large Deformations, Functional Thermodynamics and Thermoviscoelasticity, Thermodynamics with Internal State Variables and Thermo-Elasto-Viscoplasticity, Electro-Thermo-Viscoelasticity/Viscoplasticity, and Meshless Method. These new topics are added as self-contained sections or chapters. Many books in the market do not cover these topics. This invaluable book has been written for engineers and engineering scientists in a style that is readable, precise, concise, and practical. It gives the first priority to the formulation of problems, presenting the classical results as the gold standard, and the numerical approach as a tool for obtaining solutions.
Publisher: World Scientific Publishing Company
ISBN: 9789814713641
Category : Technology & Engineering
Languages : en
Pages : 838
Book Description
The second edition provides an update of the recent developments in classical and computational solid mechanics. The structure of the book is also updated to include five new areas: Fundamental Principles of Thermodynamics and Coupled Thermoelastic Constitutive Equations at Large Deformations, Functional Thermodynamics and Thermoviscoelasticity, Thermodynamics with Internal State Variables and Thermo-Elasto-Viscoplasticity, Electro-Thermo-Viscoelasticity/Viscoplasticity, and Meshless Method. These new topics are added as self-contained sections or chapters. Many books in the market do not cover these topics. This invaluable book has been written for engineers and engineering scientists in a style that is readable, precise, concise, and practical. It gives the first priority to the formulation of problems, presenting the classical results as the gold standard, and the numerical approach as a tool for obtaining solutions.
A Compendium of Partial Differential Equation Models
Author: William E. Schiesser
Publisher: Cambridge University Press
ISBN: 0521519861
Category : Computers
Languages : en
Pages : 491
Book Description
Presents numerical methods and computer code in Matlab for the solution of ODEs and PDEs with detailed line-by-line discussion.
Publisher: Cambridge University Press
ISBN: 0521519861
Category : Computers
Languages : en
Pages : 491
Book Description
Presents numerical methods and computer code in Matlab for the solution of ODEs and PDEs with detailed line-by-line discussion.
Inborn Errors of Development
Author: Charles J. Epstein
Publisher: Oxford University Press, USA
ISBN: 019514502X
Category : Medical
Languages : en
Pages : 1110
Book Description
In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.
Publisher: Oxford University Press, USA
ISBN: 019514502X
Category : Medical
Languages : en
Pages : 1110
Book Description
In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.
Mathematical Modeling Approach To Infectious Diseases, A: Cross Diffusion Pde Models For Epidemiology
Author: Schiesser William E
Publisher: World Scientific
ISBN: 9813238801
Category : Technology & Engineering
Languages : en
Pages : 460
Book Description
Publisher: World Scientific
ISBN: 9813238801
Category : Technology & Engineering
Languages : en
Pages : 460
Book Description
Dynamic Modeling of Transport Process Systems
Author: C. A. Silebi
Publisher: Elsevier
ISBN: 0080925820
Category : Technology & Engineering
Languages : en
Pages : 533
Book Description
This book presents a methodology for the development and computer implementation of dynamic models for transport process systems. Rather than developing the general equations of transport phenomena, it develops the equations required specifically for each new example application. These equations are generally of two types: ordinary differential equations (ODEs) and partial differential equations (PDEs) for which time is an independent variable. The computer-based methodology presented is general purpose and can be applied to most applications requiring the numerical integration of initial-value ODEs/PDEs. A set of approximately two hundred applications of ODEs and PDEs developed by the authors are listed in Appendix 8.
Publisher: Elsevier
ISBN: 0080925820
Category : Technology & Engineering
Languages : en
Pages : 533
Book Description
This book presents a methodology for the development and computer implementation of dynamic models for transport process systems. Rather than developing the general equations of transport phenomena, it develops the equations required specifically for each new example application. These equations are generally of two types: ordinary differential equations (ODEs) and partial differential equations (PDEs) for which time is an independent variable. The computer-based methodology presented is general purpose and can be applied to most applications requiring the numerical integration of initial-value ODEs/PDEs. A set of approximately two hundred applications of ODEs and PDEs developed by the authors are listed in Appendix 8.