Comprehensive Toxicology: Carcinogenesis PDF Download

Author: Charlene A. McQueen
Publisher:
ISBN: 9780080468822
Category : Toxicology
Languages : en
Pages : 657

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Author:
Publisher: Elsevier
ISBN: 0080468845
Category : Medical
Languages : en
Pages : 6448

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Book Description
An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version

Author: Charlene A. McQueen
Publisher: Pergamon
ISBN: 9780080423012
Category : Science
Languages : en
Pages : 524

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Comprehensive Toxicology - the first comprehensive reference work in toxicology, is an in-depth, state-of-the-art review of toxicology of unrivalled quality. It is designed to encompass investigation from a molecular level to the intact organism. Presented in a 13-volume printed form.

Author: G.T. Bowden
Publisher: Pergamon
ISBN: 9780080429779
Category : Medical
Languages : en
Pages : 498

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The purpose of Volume 12 is to provide a comprehensive overview of the field of chemical and radiation carcinogenesis with particular emphasis on molecular mechanisms. The actions of various chemical carcinogens as well as ultraviolet and ionizing radiation are discussed in the context of the multistage process of both experimental and human carcinogenesis. Background information concerning the target genes for the genetic and epigenetic modulation by carcinogens are covered. These target genes include proto-oncogenes, tumor suppressor genes, and effector genes. Various classes of carcinogens including tumor initiating, promoting, and progressing agents are discussed in terms of how they bring about critical alterations in the target genes. The functional role of these gene alterations are covered in the context of the various phenotypic changes associated with each stage of carcinogenesis. Finally, strategies for intervening with the multistep process of carcinogenesis through chemoprevention are discussed. Wherever possible the relevancy of more basic findings with experimental model systems to human carcinogenesis is emphasized.

Author: David B. Clayson
Publisher: CRC Press
ISBN: 9781420032727
Category : Medical
Languages : en
Pages : 212

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How do we know if a chemical is carcinogenic? How accurate and relevant to humans are the current assays? With the increasing influx of chemicals in our food and environment, these questions become more critical everyday. Written by an expert with more than fifty years experience in this field, Toxicological Carcinogenesis gives you a balanced and authoritative treatment of the issues. The book provides a summary of the present knowledge of chemicals that induce cancer. The author avoids the overuse of technical jargon and explains scientific concepts clearly and succinctly. He has included an appendix containing bibliographic references, making the text easier to read and keeping the information available as a reference. He covers: How carcinogens are detected in humans using epidemiology, bioassays, and alternative approaches Agents leading to human cancer such as exposure due to occupation, cigarette smoking, and diet and nutrition Carcinogenesis mechanisms The use of legislation to control exposures to noxious agents. Toxicological Carcinogenesis fills a gap in the current literature by providing just enough background information to give a complete general overview of the subject. It explores the emerging debates that related to the potential chemical causes of cancer. In addition to the comprehensive coverage the book provides, it explains the potential problems caused by possible misinformation about chemical carcinogenesis.

Author: Charlene A. McQueen
Publisher: Pergamon
ISBN: 9780080423012
Category : Science
Languages : en
Pages : 386

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Book Description
Comprehensive Toxicology - the first comprehensive reference work in toxicology, is an in-depth, state-of-the-art review of toxicology of unrivalled quality. It is designed to encompass investigation from a molecular level to the intact organism. Presented in a 13-volume printed form.

Author: Charlene A. McQueen
Publisher: Pergamon
ISBN: 9780080423012
Category : Science
Languages : en
Pages : 368

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Book Description
Comprehensive Toxicology - the first comprehensive reference work in toxicology, is an in-depth, state-of-the-art review of toxicology of unrivalled quality. It is designed to encompass investigation from a molecular level to the intact organism. Presented in a 13-volume printed form.

Author: Charlene A. McQueen
Publisher: Pergamon
ISBN: 9780080423012
Category : Science
Languages : en
Pages : 640

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Book Description
Comprehensive Toxicology - the first comprehensive reference work in toxicology, is an in-depth, state-of-the-art review of toxicology of unrivalled quality. It is designed to encompass investigation from a molecular level to the intact organism. Presented in a 13-volume printed form.

Author:
Publisher:
ISBN:
Category : Toxicology
Languages : en
Pages :

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Author: Ali S. Faqi
Publisher: Academic Press
ISBN: 0123878152
Category : Business & Economics
Languages : en
Pages : 904

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Book Description
A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics --