Complexes of Ruthenium with Ligands Containing Nitrogen Donor Atoms (microfilm). PDF Download

Author: Caesar Valko Senoff
Publisher:
ISBN:
Category : Complex compounds
Languages : en
Pages : 234

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Author: Caesar V. (Caesar Valko) Senoff
Publisher: National Library of Canada
ISBN:
Category : Complex compounds
Languages : en
Pages : 234

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Author: Ronald Osborne Harris
Publisher:
ISBN:
Category : Ruthenium
Languages : en
Pages : 400

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Author: Ka-Lai Yip
Publisher:
ISBN: 9781361245415
Category :
Languages : en
Pages :

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This dissertation, "Ruthenium and osmium-nitrogen mulitple bonded complexes with chelating nitrogen and/or oxygen atom donor ligands: synthesis, structures and reactivity studies" by Ka-lai, Yip, 葉嘉麗, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4501517 Subjects: Ruthenium compounds - Synthesis Osmium compounds - Synthesis Ligands Chelates

Author: Alvin A. Holder
Publisher: John Wiley & Sons
ISBN: 3527339574
Category : Science
Languages : en
Pages : 344

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Edited by a team of highly respected researchers combining their expertise in chemistry, physics, and medicine, this book focuses on the use of rutheniumcontaining complexes in artificial photosynthesis and medicine. Following a brief introduction to the basic coordination chemistry of ruthenium complexes and their synthesis in section one, as well as their photophysical and photochemical properties, the authors discuss in detail the major concepts of artificial photosynthesis and mechanisms of hydrogen production and water oxidation with ruthenium in section two. The third section of the text covers biological properties and important medical applications of ruthenium complexes as therapeutic agents or in diagnostic imaging. Aimed at stimulating research in this active field, this is an invaluable information source for researchers in academia, health research institutes and governmental departments working in the field of organometallic chemistry, green and sustainable chemistry as well as medicine/drug discovery, while equally serving as a useful reference also for scientists in industry.

Author: Lai-Ming Ella Wong
Publisher: Open Dissertation Press
ISBN: 9781361426609
Category :
Languages : en
Pages :

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This dissertation, "Iron and Ruthenium Complexes With Nitrogen and Oxygen Donor Ligands for Anti-cancer and Anti-viral Studies" by Lai-Ming, Ella, Wong, 黃禮明, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled IRON AND RUTHENIUM COMPLEXES WITH NITROGEN AND OXYGEN DONOR LIGANDS FOR ANTI-CANCER AND ANTI-VIRAL STUDIES Submitted by Ella Lai-Ming Wong For the degree of Doctor of Philosophy at The University of Hong Kong in February 2006 Development of drug resistance in cancer chemotherapy has stimulated the search for new anti-cancer drugs. Due to the versatile oxidation states and diverse coordination chemistry, iron and ruthenium compounds are potential candidates for new anti-cancer agents and metallopharmaceuticals. In this study, iron(II) complexes containing polypyridines as auxiliary ligand and ruthenium-oxo oxalato cluster were synthesized and characterized by X-ray crystallography, and their anti-cancer and anti-viral properties were examined. The iron(II) complexes, [Fe(R-qpy)(CH CN) ](ClO ) [qpy = 3 2 4 2 2,2′ 6′,2″ 6″,2′″ 6′″,2″″-quinquepyridine, R = H (1a) and Ph (1b)] and [Fe(Py -OH)(CH CN)](ClO ) (2) [Py-OH = 5 3 4 2 5 2,6-bis[hydroxybis(2-pyridyl)methyl]pyridine] were stable in physiological buffers and exhibited significant cytotoxicities against some established human cancer cell lines. According to the MTT assay, their IC values were 0.1 - 70 50 M; they exhibited more pronounced cytotoxicities against hepatocellular carcinoma cells than against other type of cancer cells. Flow cytometry studies revealed that 1a could cause cell cycle arrest of HeLa cells at the S-phase, which involved DNA synthesis. Complex 1a was found to catalyze epoxidation, aziridination and amidation of hydrocarbons with good substrate conversions and high product yields. The iron(IV)-oxo and -imido reactive intermediates were generated in situ and their formulations were verified by mass spectroscopy. By Evan's method, the result supported the iron(IV) formulation with a low-spin d electronic configuration (S = 1). A ruthenium-oxo oxalato cluster formulated as Na [Ru ( -O) (C O ) ] (3) 7 4 3 4 2 4 6 was prepared. Structural studies and magnetic measurements revealed that the ruthenium atoms adopted the oxidation states of +III, +III, +III and +IV. Complex 3 showed anti-HIV properties on infected cells. Using the HIV-1(BaL) virus infected Hut/CCR5 cells, 3 was found to exhibit > 90% inhibition on viral replication at 5 M concentration. Similar findings were obtained with other HIV-infected cell lines including GHOST/CXCR4 and PBMCs. Complex 3 was non-cytotoxic to these cells even at 50 M concentration. Relevant to anti-HIV activity, 3 was found to inhibit HIV-1 reverse transcriptase activity in vitro with IC = 2 nM. 50 III A series of ruthenium complexes, cis-[Ru (Me -tet)Cl ]ClO [Me -tet = 6 2 4 6 N, N, N′, N′-tetramethyl-3,6-dimethyl-3,6-diazaoctane-1,8-diamine], III III trans-[Ru (pyz) Cl]Cl (pyz = pyrazole), trans-[Ru (3Mepyz) Cl ]Cl 4 2 4 2 II III [3Mepyz = 3-methylpyrazole], [Ru (3Mepyz) ]Cl, [Ru (salen)(H O) ]Y 6 2 2 2 [H-salen = N, N'-bis(salicylidene)ethylenediamine, Y = Cl and PF ], 2 6 III cis-[Ru (cyclen)Cl]Cl [cyclen = 1,4,7,10-tetraazacyclododecane], 2III trans-[Ru (BiIml) Cl]Y [BiIml = biimidazole, Y = Cl and PF], and 2 2 6 II cis-[Ru (BiIml) (DMSO) ](ClO ) were examined for anti-cancer activities. 2 2 4 2 Their IC values were 4 - 100 M and their cytotoxicities could be affected by 50 the auxiliary ligands. The reduction potentials of the ruthenium compounds were +/0 in

Author: Ajay Kumar Mishra
Publisher: CRC Press
ISBN: 1351616498
Category : Science
Languages : en
Pages : 260

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This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level. The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity. The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.

Author: M. Andreina Moreno
Publisher:
ISBN: 9789524587112
Category :
Languages : en
Pages : 46

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Author:
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ISBN:
Category :
Languages : en
Pages :

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(Uncorrected OCR) Abstract of thesis entitled RUTHENIUM AND OSMIUM-NITROGEN MULITPLE BONDED COMPLEXES WITH CHELATING NITROGEN AND / OR OXYGEN ATOM DONOR LIGANDS: SYNTHESIS, STRUCTURES AND REACTIVITY STUDIES Submitted by Yip Ka Lai for the degree of Doctor of Philosophy at The University of Hong Kong in March 2005 The chemistry of late transition metal-nitrido complexes have been a growing interest especially for nitrido-ruthenium(VI) and -osmium(VI) metal complexes. However, the reactivity studies on those nitride complexes are sparse in the literature. As a result, the reactivities of nitridoruthenium(VI) complexes toward nucleophilic, electrophilic and oxidizing agents were studied. [Ru^CNXL^Cl] [H2L1 = 2,6-bis(2,2-diphenyl-2-hydroxyethyl)pyridine] underwent nitrogen atom transfer reaction with PPI13, PPhMe2 (dimethylphenylphosphine) and dppe [l,2-bis(diphenylphosphino)ethylene] to give [RuIII(HL1)(PPh3)Cl2], [Ru^XPPhMe^Cl] and [RuIII(L1)(dppe)Cl], respectively. In the presence of py or Hpz, the reaction of [Ru^^XL^Cl] gave [RuIII(L1)(py)2Cl] and [RuIII(L1)(Hpz)3]Cl as respective products. An unsymmetrical u-nitrido dinuclear ruthenium complex, [Ru^L^ChCu-N^u^L'XCsHioN^l], was formed upon reaction of [Ru^CNXL^Cl] with 2,6-dimethylaniline. Excess (Me30)BF4 reacted with [Ru^CNXL^Cl] to give a dinuclear u-OH complex, [Ru2(N)2(L1)2(OH)]PF6. For the analogous reaction with [n-Bu4N][MVI(NXL)] [L = L2 and L3; M = Os and Ru; H4L = l,2-dichloro-4,5-bis(2-hydroxybenzamido)benzene, H4L = l,2-bis(2-hydroxybenzamido)benzene], protonation at the auxiliary ligand occurred to give [M^CNXHL)] as product. Oxidation of [n-Bu4N][OsVI(N)(L2)] by PhI(OAc)2 produced [n-Bu4N][OsVI(N)(L202)] in 10% yield. Based on X-ray crystal analysis, the coordinated phenoxy moiety was converted to a benzoquinone moiety while the Os=N group remained intact. A synthetic route for preparing ruthenium pyridyl-amine complexes bearing chelating tertiary amine 'ligands was developed. At pH 1.0, the cyclic vo.

Author: R. J. Paske
Publisher:
ISBN:
Category :
Languages : en
Pages : 107

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