Author: K. Whaley Publisher: Springer Science & Business Media ISBN: 9401122148 Category : Medical Languages : en Pages : 385
Book Description
Since the first edition of Complement in Health and Disease was published in 1986, significant advances have been made. The cDNAs for all of the components and some of the receptors have been cloned and sequenced. The chromosomal localization and the structural organization of a number of these genes have now been determined. These advances are now facilitating research into the structure of the complement proteins, the nature of the complement deficiency syndromes, the regulation of complement gene expression and the role of complement in different diseases. This edition contains contributions from both basic and clinical scientists in a format which we hope will appeal to both immunologists and physicians who wish to know more about this fascinating and important host defence system. The introductory chapter by John Weiler presents a historical background to research on the complement system and describes the biochemical events occurring during activation of the system. In Chapter 2 Alastair Dodds and Tony Day discuss the phylogeny and evolution of the complement system. The techniques of protein chemistry and molecular biology have provided powerful insights into the modular structure of complement proteins and the evolution of the complement system. The structure and organisation of the complement genes is described in Chapter 3 by Ken Reid and Duncan Campbell. This chapter describes the modular structure of the complement proteins and some of the mutations which are responsible for deficiencies of individual components.
Author: Nancy M. Sullivan Publisher: Routledge ISBN: 1317513649 Category : Language Arts & Disciplines Languages : en Pages : 252
Book Description
This innovative grammar text is an ideal resource for writers, language students, and current and future classroom teachers who need an accessible "refresher" in a step-by-step guide to essential grammar. Rather than becoming mired in overly detailed linguistic definitions, Nancy Sullivan helps writers and students understand and apply grammatical concepts and develop the skills they need to enhance their own writing. Along with engaging discussions of both contemporary and traditional terminology, Sullivan's text provides clear explanations of the basics of English grammar and a highly practical, hands-on approach to mastering the use of language. Complementing the focus on constructing excellent sentences, every example and exercise set is contextually grounded in language themes. Teachers, students, and writers will appreciate the streamlined, easy-to-understand coverage of essential grammar, as well as the affordable price. This is an ideal textbook for future teachers enrolled in an upper-level grammar course yet is also suitable for any writing course across disciplines where grammatical precision is important. Instructor materials accompanying the text provide teachers with activities designed for face-to-face, hybrid, and online instruction to enliven these basic grammar lessons as well as writing activities to integrate these concepts into students' own writing.
Author: Erik J.M. Toonen Publisher: Frontiers Media SA ISBN: 2832540880 Category : Medical Languages : en Pages : 364
Book Description
The complement system is an important innate immune surveillance network that has a key role in protecting our bodies against pathogens and other threats. It is a highly complex system consisting of approximately 50 soluble and cell surface-bound proteins that interact to eliminate danger signals. These signals include factors such as invading microorganisms, necrotic cells, and immune complexes. Furthermore, complement can link innate and adaptive immune responses by regulating T cell and B cell responses. The complement system is tightly regulated to avoid uncontrolled activation. Dysregulation of the complement system has been linked to numerous diseases, both rare and common. Uncontrolled or exaggerated activation can lead to life-threatening conditions such as dysregulation of coagulation, fibrinolysis, systemic inflammation and shock, and possible failure of a variety of organs such as the eyes, kidneys, skin, brain, and vascular system. In recent years, the complement system has gained increased interest, especially as a promising candidate for therapeutic intervention. Eculizumab, the first approved complement inhibitor, is highly effective for treating atypical hemolytic uremic syndrome (aHUS) and paroxysmal nocturnal hemoglobinuria (PNH). Many more drug candidates are currently evaluated in ongoing clinical trials.
Author: Martin Flajnik Publisher: Lippincott Williams & Wilkins ISBN: 1975142527 Category : Medical Languages : en Pages : 3597
Book Description
Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.
Author: Edward Bittar Publisher: Elsevier ISBN: 008053449X Category : Science Languages : en Pages : 351
Book Description
As this volume demonstrates, immunobiology is a young science which is undergoing explosive growth. Judged by results, it is already an elaborate discipline which cuts across every other area in biomedical research and even has its own vocabolary (e.g., the "veto" effect). Rather than inculcate the habit of superficial learning by having the student go through a maze of details, we have sought to gather together sixteen essays that range from T-cells to psyhoneuroimmunology. This is keeping with the growing understanding that the student is expected to read and think far more for herself/himself.Next to nothing is known about innate immunity. However, recent evidence suggests that collectins might bridge the gap between innate immunity and specific clonal immune responses. Collectins are soluble effector proteins that include serum mannose-binding protein, and lung surfactants A and D. They are considered to be ante-antibodies.
Author: Nadey Hakim Publisher: Springer Science & Business Media ISBN: 1447136896 Category : Medical Languages : en Pages : 452
Book Description
It is like a fairy story! Or at least a beautiful epic, a truly significant page in the history of medicine, a staggering scene in which several actors come into play, both fundamentalists and clinical practitioners, eager to place all these new developments at the disposal of those suffering from ill health. Everyone is passionate about their work, be it providing new knowledge or perfecting new therapeutic methods. Man has always been fascinated by the possibility of replacing a damaged organ with a healthy one. Several attempts have been made over the centuries, and some miracles have been reported, such as those of Saint Damien and Saint Come as illustrated by Fra Angelico. The modern saga, however, started more modestly on the mouse. It is on the mouse that the first tissue group was discovered; yet the study of human tissue groups could only be carried out on a human. One human must be subjected to the thousands of tests that have enabled us to unravel the extraordinary complexity of the HLA system.
Author: Aaron Ivey Publisher: B&H Books ISBN: 9781535996693 Category : Religion Languages : en Pages : 256
Book Description
Bestselling authors Jamie Ivey (host of the Happy Hour podcast) and Aaron Ivey write about God's design for a happy, healthy, flourishing marriage.
Author: Klaus D. Elgert Publisher: John Wiley & Sons ISBN: 0470081570 Category : Medical Languages : en Pages : 738
Book Description
Blends biology, clinical science, genetics, and molecular biology of the immune system to provide a complete account of our knowledge of immunology New features include full-color artwork and design, over 50 new figures, and text that has been completely revised to reflect the very latest references Incorporates a variety of pedagogical aids to assist students in the learning process, including chapter outlines, objectives, and summaries, as well as a self-evaluation section
Author: K. Whaley
Author: Nancy M. Sullivan
Author: National Library of Medicine (U.S.)
Author: Erik J.M. Toonen
Author: James W. Ney
Author: Martin Flajnik
Author: Edward Bittar
Author: Nadey Hakim
Author: Aaron Ivey
Author: Klaus D. Elgert