Company Profiles: Funxional Therapeutics Ltd (FXT). PDF Download

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Languages : en
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Author: Majid Ezzati
Publisher: World Health Organization
ISBN: 9241580313
Category : CD-ROMs
Languages : en
Pages : 2282

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Book Description
Provides a comprehensive assessment of the scientific evidence on prevalence and the resulting health effects of a range of exposures that are know to be hazardous to human health, including childhood and maternal undernutrition, nutritional and physiological risk factors for adult health, addictive substances, sexual and reproductive health risks, and risks in the physical environments of households and communities, as well as among workers. This book is the culmination of over four years of scientific equiry and data collection, know as the comparative risk assessment (CRA) project.

Author: Graziano Pinna
Publisher:
ISBN: 9781634820769
Category :
Languages : en
Pages : 412

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Fluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.

Author: Jyotsna Pundir
Publisher: Cambridge University Press
ISBN: 1107480698
Category : Computers
Languages : en
Pages : 325

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Provides evidence-based guidelines in schematic flowcharts, representing a step-by-step method of solving clinical problems in gynaecology.

Author: Elliot Mendelsohn
Publisher: Springer Science & Business Media
ISBN: 1461572886
Category : Science
Languages : en
Pages : 351

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This is a compact mtroduction to some of the pnncipal tOpICS of mathematical logic . In the belief that beginners should be exposed to the most natural and easiest proofs, I have used free-swinging set-theoretic methods. The significance of a demand for constructive proofs can be evaluated only after a certain amount of experience with mathematical logic has been obtained. If we are to be expelled from "Cantor's paradise" (as nonconstructive set theory was called by Hilbert), at least we should know what we are missing. The major changes in this new edition are the following. (1) In Chapter 5, Effective Computability, Turing-computabIlity IS now the central notion, and diagrams (flow-charts) are used to construct Turing machines. There are also treatments of Markov algorithms, Herbrand-Godel-computability, register machines, and random access machines. Recursion theory is gone into a little more deeply, including the s-m-n theorem, the recursion theorem, and Rice's Theorem. (2) The proofs of the Incompleteness Theorems are now based upon the Diagonalization Lemma. Lob's Theorem and its connection with Godel's Second Theorem are also studied. (3) In Chapter 2, Quantification Theory, Henkin's proof of the completeness theorem has been postponed until the reader has gained more experience in proof techniques. The exposition of the proof itself has been improved by breaking it down into smaller pieces and using the notion of a scapegoat theory. There is also an entirely new section on semantic trees.

Author: Khalid Sayood
Publisher: Elsevier
ISBN: 012620862X
Category : Computers
Languages : en
Pages : 704

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"Khalid Sayood provides an extensive introduction to the theory underlying today's compression techniques with detailed instruction for their applications using several examples to explain the concepts. Encompassing the entire field of data compression Introduction to Data Compression, includes lossless and lossy compression, Huffman coding, arithmetic coding, dictionary techniques, context based compression, scalar and vector quantization. Khalid Sayood provides a working knowledge of data compression, giving the reader the tools to develop a complete and concise compression package upon completion of his book."--BOOK JACKET.

Author: Heinz von Foerster
Publisher: Springer Science & Business Media
ISBN: 0387217223
Category : Computers
Languages : en
Pages : 364

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Book Description
In these ground-breaking essays, Heinz von Foerster discusses some of the fundamental principles that govern how we know the world and how we process the information from which we derive that knowledge. The author was one of the founders of the science of cybernetics.

Author: John S. Gray
Publisher: Oxford University Press
ISBN: 0198569017
Category : Nature
Languages : en
Pages : 249

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Book Description
Marine sediments are the second largest habitat on earth and yet are poorly understood. This book gives a broad coverage of the central topics in the ecology of soft sediments.

Author: Ramona Rajapakse
Publisher: Springer Nature
ISBN: 3030817806
Category : Medical
Languages : en
Pages : 368

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Book Description
This book uses new thinking on precision medicine and the interplay of genetic factors, the microbiome, and external triggers to build on the core concepts of inflammatory bowel disease. It outlines the latest findings in targeting therapies to the individual patient with Crohn’s and colitis, management of chronic infections in the setting of immunomodulators and biologics, non-surgical therapy of dysplasia in colitis patients, and redefining and structuring the problematic pouch. In addition, this book features useful chapters dedicated to the economic aspects of IBD in an increasingly constrained healthcare system, as well as the patient experience and the role of subspecialist telemedicine care. Written by specialists and thought leaders in the field, Inflammatory Bowel Disease: Pathogenesis, Diagnosis and Management provides a concise but highly relevant account of the latest thinking and concepts in IBD.