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Author: Clévio Nóbrega Publisher: Springer ISBN: 3319717790 Category : Medical Languages : en Pages : 467
Book Description
This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.
Author: Clévio Nóbrega Publisher: Springer ISBN: 3319717790 Category : Medical Languages : en Pages : 467
Book Description
This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.
Author: Emil F. Coccaro Publisher: Academic Press ISBN: 0128138580 Category : Psychology Languages : en Pages : 274
Book Description
Intermittent Explosive Disorder: Etiology, Assessment, and Treatment provides a complete overview on this disorder, focusing on its etiology, how the disorder presents, and the clinical assessment and treatment methods currently available. The book presents the history of the disorder, discusses the rationale for its inclusion in the DSM, and includes diagnostic considerations, comorbidity, epidemiology, intervention, and how treatments have evolved. Each section is bolstered by clinical case material that provides real-world context and clinical lessons on how to distinguish intermittent explosive disorder from other presentations of aggression.
Author: Roberto J. Guiloff Publisher: Springer Science & Business Media ISBN: 1447137876 Category : Medical Languages : en Pages : 537
Book Description
Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A general section deals with the ethical aspects, drug development and regulatory requirements, basic trial designs and the statistics used. A diseases section tackles specific aspects of disorders, focusing on the relevant ethical issues, outcome variables and experience with large multicentre trials.
Author: Christopher Gillberg Publisher: Cambridge University Press ISBN: 9781139447416 Category : Medical Languages : en Pages : 776
Book Description
Originally published in 2006, this authoritative clinical handbook provides a detailed overview of the main disorders encountered by child and adolescent psychiatrists in clinical practice, ranging from eating, sleep and affective disorders to substance abuse, gender identity disorder and sexual abuse. The approach is evidence based and emphasis is on good clinical practice and quality control of patient care. In contrast to other books in the field, the authors' intention is not to cover exhaustively all the relevant science, but rather to present in condensed form any research findings that are significant for clinical practice. For coherence, each chapter is constructed in the same way: introduction, definition and classification, epidemiology, the clinical picture, aetiology, treatment and outcome. The disorders covered are based on the ICD- 10 and DSM-IV classifications, and appendices include documents for assessment of intervention planning and evaluation.
Author: Neal Simon Publisher: Realclear Publishing ISBN: 9781645430643 Category : Political Science Languages : en Pages : 264
Book Description
"The alternate domination of one faction over another, natural to party dissension...is itself a frightful despotism." -- George Washington George Washington's nightmare has been realized. Despite his warning about the negative effects of party loyalties, the U.S. government has become paralyzed by partisanship, allowing national challenges to go unaddressed. As an independent candidate for U.S. Senate in 2018, Neal Simon witnessed the destructive nature of modern American politics. He experienced firsthand the perverse incentives that push candidates and lawmakers to ideological extremes. He watched as party leaders resisted pragmatic solutions to our nation's problems. He saw politicians prioritize loyalty to their party bases over progress for the American people. In this comprehensive analysis of United States politics, Simon shows how degradations in party primaries, campaign finances, and election rules have caused American self-government to collapse into gridlock and divisiveness. However, the American promise is so much greater. As the first U.S. president noted in his famed address, "The basis of our political systems is the right of the people to make and to alter their constitutions of government." Capitalizing on personal insight derived from Simon's political campaign along with extensive research, Contract to Unite America provides specific, practical solutions for an improved government and a better tomorrow.
Author: Katherine D. Warburton Publisher: Cambridge University Press ISBN: 1107092191 Category : Medical Languages : en Pages : 357
Book Description
The association between violence and mental illness is well studied, yet remains highly controversial. Currently, there does appear to be a trend of increasing violence in hospital settings, including both civilly and forensically committed populations. In fact, physical aggression is the primary reason for admission to many hospitals. Given that violence is now often both a reason for admission and a barrier to discharge, there is a pressing need for violence to be re-conceptualized as a primary medical condition, not as the by-product of one. Furthermore, treatment settings need to be enhanced to address the new types of violence exhibited in inpatient environments and this modification needs to be geared toward balancing safety with treatment. This book focuses on violence from assessment, through underlying neurobiology, to treatment and other recommendations for practice. This will be of interest to forensic psychiatrists, general adult psychiatrists, psychiatric residents, psychologists, psychiatric social workers and rehabilitation therapists.
Author: Mary B. Ballou Publisher: Guilford Press ISBN: 9781572307995 Category : Psychology Languages : en Pages : 344
Book Description
This volume presents work at the interface of feminist theory and mental health. The editors a stellar array of contributors to continue the vital process of feminist theory building and critique.
Author: Anthony J. Rothschild Publisher: American Psychiatric Pub ISBN: 1585624055 Category : Medical Languages : en Pages : 426
Book Description
"The Evidence-Based Guide to Antipsychotic Medications" is a table-rich, comprehensive overview of current knowledge regarding the use of antipsychotic medications to treat a broad range of psychiatric conditions, from anxiety disorders to schizophrenia.
Author: Julie Holland Publisher: Inner Traditions / Bear & Co ISBN: 9780892818570 Category : Medical Languages : en Pages : 470
Book Description
Written by the world's leading experts on MDMA, "Ecstasy: The Complete Guide" takes the first unbiased look at the risks and the benefits of this unique drug, including the science of how it works; its promise as a treatment for depression, post-traumatic stress disorders, and other mental illnesses; and how to minimize the risks of use.
Author: John C. Markowitz Publisher: American Psychiatric Pub ISBN: 9780880488365 Category : Medical Languages : en Pages : 188
Book Description
The book compiles the results of several research studies on this subject. It discusses important developments in interpersonal psychotherapy research and its translation into clinical practice. It describes typical phases of treatments and highlights applications for patient populations, which have seen results from interpersonal psychotherapy.
Author: Clévio Nóbrega
Author: Clévio Nóbrega
Author: Emil F. Coccaro
Author: Roberto J. Guiloff
Author: Christopher Gillberg
Author: Neal Simon
Author: Katherine D. Warburton
Author: Mary B. Ballou
Author: Anthony J. Rothschild
Author: Julie Holland
Author: John C. Markowitz