Author: Marika Hellqvist GrebergPublisher:
ISBN:
Category : Genetic Transcription
Languages : en
Pages : 114
Book Description
Cloning and Characterization of FREACs, Human Forkhead Transcription Factors
Author: Marika Hellqvist GrebergPublisher:
ISBN:
Category : Genetic Transcription
Languages : en
Pages : 114
Book Description
Cloning and Characterization of Human Forkhead Proteins
Author: Stefan PierrouPublisher:
ISBN: 9789171970527
Category :
Languages : en
Pages : 48
Book Description
Cloning and Characterization of a Forkhead Transcription Factor Gene, FoxOla From Thirteen-Lined Ground Squirrel
Author: Publisher:
ISBN:
Category :
Languages : en
Pages : 8
Book Description
This research analyzes the regulation of ischemic tolerance in hibernating thirteen-lined ground squirrels (Spermophilus tridecemlineatus). Hibernation is studied because it represents a unique state of reversible suspended animation associated with tolerance to an otherwise lethal reduction of core body temperature and metabolism. An integral aspect of hibernation is the profound decrease of cerebral perfusion without neurological damage. As such, hibernation serves as a model for studying natural tolerance to brain ischemia. Identification of regulatory mechanisms that control hibernation in ground squirrels may guide efforts to develop improved treatments for stroke and brain trauma. It was previously shown that phosphorylation of Akt (protein kinase B), an insulin-like growth factor-regulated serine/threonine kinase, was significantly reduced as was its kinase activity in hibernating thirteen-lined ground squirrels. Here we studied the forkhead (FH) in rhabdomyosarcoma (FKHR) transcription factor, which is controlled by Akt signaling and is involved in regulating cell cycle progression and cell death. A cDNA derived from brains of S. tridecemlineatus, encoding a specific FKHR transcription factor, FoxO1a, was cloned and sequenced, and the amino acid sequence of the protein was deduced. FoxO1a is composed of 653 amino acids and has a predicted molecular mass of 69.4 kilodaltons (kDa). Here, for the first time, we report the contrary expression of phosphorylation of two members in the insulin-like growth factor signaling pathway during hibernation (i.e., phosphorylated FKHR was significantly up-regulated as phosphorylation of its upstream kinase, Akt, was significantly down-regulated). Further study is required to identify the possible connection between FoxO1a and Akt activity and the possible role of such interactions in hibernation.
Cloning and Characterization of the Human Basal Transcription Factor, TFIIE
Author: Mary Elizabeth MaxonPublisher:
ISBN:
Category :
Languages : en
Pages : 354
Book Description
Cloning and Characterization of Five Human Members of the Winged- Helix Family of Transcription Factors
Author: Cloning and Characterization of Human Constitutive Photomorphogenesis1, a RING Finger Protein that Interacts with Jun Transcription Factors and Modulates Their Transcriptional Activity
Author: Simona DentiForkhead Transcription Factors
Author: Kenneth MaiesePublisher: Springer Science & Business Media
ISBN: 1441915990
Category : Medical
Languages : en
Pages : 283
Book Description
Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders. Equally important, Forkhead Transcription Factors: Vital Elements in Biology and Medicine clearly sets a precedent for the necessity to understand the diverse and complex nature of forkhead proteins since this family of transcription factors can limit as well as foster disease progression depending upon the cellular environment. The presentation and discussion of innovative studies and especially those that examine previously unexplored pathways that may influence clinical survival and longevity offer an exciting approach to address the potential of forkhead transcription factors for new therapeutic avenues in multiple disciplines.
Author: Frank Mercurio
Author: Susan Mary Varghese
Author: Michel van Duin