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Author: Paul Meehl Publisher: Echo Point Books & Media ISBN: 9781626542303 Category : Medical Languages : en Pages : 164
Book Description
"Clinical versus Statistical Prediction" is Paul Meehl's famous examination of benefits and disutilities related to the different ways of combining information to make predictions. It is a clarifying analysis as relevant today as when it first appeared. A major methodological problem for clinical psychology concerns the relation between clinical and actuarial methods of arriving at diagnoses and predicting behavior. Without prejudging the question as to whether these methods are fundamentally different, we can at least set forth the obvious distinctions between them in practical applications. The problem is to predict how a person is going to behave: What is the most accurate way to go about this task? "Clinical versus Statistical Prediction" offers a penetrating and thorough look at the pros and cons of human judgment versus actuarial integration of information as applied to the prediction problem. Widely considered the leading text on the subject, Paul Meehl's landmark analysis is reprinted here in its entirety, including his updated preface written forty-two years after the first publication of the book. This classic work is a must-have for students and practitioners interested in better understanding human behavior, for anyone wanting to make the most accurate decisions from all sorts of data, and for those interested in the ethics and intricacies of prediction. As Meehl puts it, " "When one is dealing with human lives and life opportunities, it is immoral to adopt a mode of decision-making which has been demonstrated repeatedly to be either inferior in success rate or, when equal, costlier to the client or the taxpayer.""
Author: Paul Meehl Publisher: Echo Point Books & Media ISBN: 9781626542303 Category : Medical Languages : en Pages : 164
Book Description
"Clinical versus Statistical Prediction" is Paul Meehl's famous examination of benefits and disutilities related to the different ways of combining information to make predictions. It is a clarifying analysis as relevant today as when it first appeared. A major methodological problem for clinical psychology concerns the relation between clinical and actuarial methods of arriving at diagnoses and predicting behavior. Without prejudging the question as to whether these methods are fundamentally different, we can at least set forth the obvious distinctions between them in practical applications. The problem is to predict how a person is going to behave: What is the most accurate way to go about this task? "Clinical versus Statistical Prediction" offers a penetrating and thorough look at the pros and cons of human judgment versus actuarial integration of information as applied to the prediction problem. Widely considered the leading text on the subject, Paul Meehl's landmark analysis is reprinted here in its entirety, including his updated preface written forty-two years after the first publication of the book. This classic work is a must-have for students and practitioners interested in better understanding human behavior, for anyone wanting to make the most accurate decisions from all sorts of data, and for those interested in the ethics and intricacies of prediction. As Meehl puts it, " "When one is dealing with human lives and life opportunities, it is immoral to adopt a mode of decision-making which has been demonstrated repeatedly to be either inferior in success rate or, when equal, costlier to the client or the taxpayer.""
Author: Ewout W. Steyerberg Publisher: Springer ISBN: 3030163997 Category : Medical Languages : en Pages : 558
Book Description
The second edition of this volume provides insight and practical illustrations on how modern statistical concepts and regression methods can be applied in medical prediction problems, including diagnostic and prognostic outcomes. Many advances have been made in statistical approaches towards outcome prediction, but a sensible strategy is needed for model development, validation, and updating, such that prediction models can better support medical practice. There is an increasing need for personalized evidence-based medicine that uses an individualized approach to medical decision-making. In this Big Data era, there is expanded access to large volumes of routinely collected data and an increased number of applications for prediction models, such as targeted early detection of disease and individualized approaches to diagnostic testing and treatment. Clinical Prediction Models presents a practical checklist that needs to be considered for development of a valid prediction model. Steps include preliminary considerations such as dealing with missing values; coding of predictors; selection of main effects and interactions for a multivariable model; estimation of model parameters with shrinkage methods and incorporation of external data; evaluation of performance and usefulness; internal validation; and presentation formatting. The text also addresses common issues that make prediction models suboptimal, such as small sample sizes, exaggerated claims, and poor generalizability. The text is primarily intended for clinical epidemiologists and biostatisticians. Including many case studies and publicly available R code and data sets, the book is also appropriate as a textbook for a graduate course on predictive modeling in diagnosis and prognosis. While practical in nature, the book also provides a philosophical perspective on data analysis in medicine that goes beyond predictive modeling. Updates to this new and expanded edition include: • A discussion of Big Data and its implications for the design of prediction models • Machine learning issues • More simulations with missing ‘y’ values • Extended discussion on between-cohort heterogeneity • Description of ShinyApp • Updated LASSO illustration • New case studies
Author: Margaret Sullivan Pepe Publisher: OUP Oxford ISBN: 019158861X Category : Medical Languages : en Pages : 319
Book Description
This book describes statistical techniques for the design and evaluation of research studies on medical diagnostic tests, screening tests, biomarkers and new technologies for classification and prediction in medicine.
Author: Paul E. Meehl Publisher: Jason Aronson ISBN: 9781568218311 Category : Psychology Languages : en Pages : 149
Book Description
This volume explores clinical issues, such as: can we rely on clinical expertise in making decisions about people's lives; when should statistical data be used; and what kind of treatment is best for a particular patient?
Author: Hans van Houwelingen Publisher: CRC Press ISBN: 1439835438 Category : Mathematics Languages : en Pages : 250
Book Description
There is a huge amount of literature on statistical models for the prediction of survival after diagnosis of a wide range of diseases like cancer, cardiovascular disease, and chronic kidney disease. Current practice is to use prediction models based on the Cox proportional hazards model and to present those as static models for remaining lifetime a
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309171148 Category : Medical Languages : en Pages : 221
Book Description
Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Author: Thomas A. Gerds Publisher: CRC Press ISBN: 0429764235 Category : Mathematics Languages : en Pages : 249
Book Description
Medical Risk Prediction Models: With Ties to Machine Learning is a hands-on book for clinicians, epidemiologists, and professional statisticians who need to make or evaluate a statistical prediction model based on data. The subject of the book is the patient’s individualized probability of a medical event within a given time horizon. Gerds and Kattan describe the mathematical details of making and evaluating a statistical prediction model in a highly pedagogical manner while avoiding mathematical notation. Read this book when you are in doubt about whether a Cox regression model predicts better than a random survival forest. Features: All you need to know to correctly make an online risk calculator from scratch Discrimination, calibration, and predictive performance with censored data and competing risks R-code and illustrative examples Interpretation of prediction performance via benchmarks Comparison and combination of rival modeling strategies via cross-validation Thomas A. Gerds is a professor at the Biostatistics Unit at the University of Copenhagen and is affiliated with the Danish Heart Foundation. He is the author of several R-packages on CRAN and has taught statistics courses to non-statisticians for many years. Michael W. Kattan is a highly cited author and Chair of the Department of Quantitative Health Sciences at Cleveland Clinic. He is a Fellow of the American Statistical Association and has received two awards from the Society for Medical Decision Making: the Eugene L. Saenger Award for Distinguished Service, and the John M. Eisenberg Award for Practical Application of Medical Decision-Making Research.
Author: Pieter Kubben Publisher: Springer ISBN: 3319997130 Category : Medical Languages : en Pages : 219
Book Description
This open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book’s promise is “no math, no code”and will explain the topics in a style that is optimized for a healthcare audience.
Author: Paul Meehl
Author: Paul Meehl
Author: Ewout W. Steyerberg
Author: Paul E. Meehl
Author: Margaret Sullivan Pepe
Author: Paul E. Meehl
Author: Paul E. Meehl
Author: Hans van Houwelingen
Author: Institute of Medicine
Author: Thomas A. Gerds
Author: Pieter Kubben