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Author: K. C. Nicolaou Publisher: Wiley-VCH ISBN: 9783527348770 Category : Science Languages : en Pages : 0
Book Description
Fourth volume of a classic in the field of organic synthesis, describing retrosynthetic analysis and total synthesis of important molecules Classics in Total Synthesis IV is a compilation of highly important synthetical methods which lead to a complex molecule with valuable properties. From the complex architectures of natural products to the streamlined synthesis of functional molecules, each chapter in Classics in Total Synthesis IV unfolds a unique story. The interplay of mechanisms, reactivity, selectivity, and stereochemical aspects is thoroughly examined, echoing the pedagogical format that has become synonymous with this series. Well-designed graphics are included throughout, and the most important parts of the reaction sequences are highlighted. This volume encapsulates the culmination of new methodologies, emerging trends, and a selection of significant total syntheses undertaken from 2009 to 2022 while additionally including two earlier syntheses from 1979 and 1992 for comparison and to highlight the development of organic synthesis over the past decades. The careful balance between historical context, comments on the molecules' impact to humankind, and the design and execution aspects of each synthesis creates a narrative that is not only clear but also intellectually stimulating. Written by K.C. Nicolaou and co-workers, Classics in Total Synthesis IV includes 16 chapters covering: Coupling and rearrangement reactions Recent advances in nonenzymatic enantioselective cyclization Cycloaddition and annulation reactions C-H functionalization and transition metal-mediated C-H activation Electroorganic chemistry and visible-light photoredox catalysis HAT-initiated olefin hydrogenation, isomerization and hydrofunctionalization Joining its predecessors in weaving together the threads of scientific discovery, challenge, and intellectual pursuit and establishing strong connections with biology and medicine, Classics in Total Synthesis IV is an essential reference for all future and present organic chemists.
Author: K. C. Nicolaou Publisher: Wiley-VCH ISBN: 9783527348770 Category : Science Languages : en Pages : 0
Book Description
Fourth volume of a classic in the field of organic synthesis, describing retrosynthetic analysis and total synthesis of important molecules Classics in Total Synthesis IV is a compilation of highly important synthetical methods which lead to a complex molecule with valuable properties. From the complex architectures of natural products to the streamlined synthesis of functional molecules, each chapter in Classics in Total Synthesis IV unfolds a unique story. The interplay of mechanisms, reactivity, selectivity, and stereochemical aspects is thoroughly examined, echoing the pedagogical format that has become synonymous with this series. Well-designed graphics are included throughout, and the most important parts of the reaction sequences are highlighted. This volume encapsulates the culmination of new methodologies, emerging trends, and a selection of significant total syntheses undertaken from 2009 to 2022 while additionally including two earlier syntheses from 1979 and 1992 for comparison and to highlight the development of organic synthesis over the past decades. The careful balance between historical context, comments on the molecules' impact to humankind, and the design and execution aspects of each synthesis creates a narrative that is not only clear but also intellectually stimulating. Written by K.C. Nicolaou and co-workers, Classics in Total Synthesis IV includes 16 chapters covering: Coupling and rearrangement reactions Recent advances in nonenzymatic enantioselective cyclization Cycloaddition and annulation reactions C-H functionalization and transition metal-mediated C-H activation Electroorganic chemistry and visible-light photoredox catalysis HAT-initiated olefin hydrogenation, isomerization and hydrofunctionalization Joining its predecessors in weaving together the threads of scientific discovery, challenge, and intellectual pursuit and establishing strong connections with biology and medicine, Classics in Total Synthesis IV is an essential reference for all future and present organic chemists.
Author: K. C. Nicolaou Publisher: John Wiley & Sons ISBN: 3527292314 Category : Science Languages : en Pages : 826
Book Description
K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.
Author: K. C. Nicolaou Publisher: John Wiley & Sons ISBN: 3527329579 Category : Science Languages : en Pages : 788
Book Description
K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Adopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods. A wonderful tool for learning and teaching and a must-have for all future and present organic and biochemists.
Author: Rodney A. Fernandes Publisher: John Wiley & Sons ISBN: 1119295203 Category : Science Languages : en Pages : 283
Book Description
Presents a comprehensive account of established protecting-group-free synthetic routes to molecules of medium to high complexity This book supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and back the global need of practicing green chemistry. The only resource of its kind to focus entirely on protecting-group-free synthesis, it is edited by a leading practitioner in the field, and features enlightening contributions by top experts and researchers from across the globe. The introductory chapter includes a concise review of historical developments, and discusses the concepts, need for, and future prospects of protecting-group-free synthesis. Following this, the book presents information on protecting-group-free synthesis of complex natural products and analogues, heterocycles, drugs, and related pharmaceuticals. Later chapters discuss practicing protecting-group-free synthesis using carbohydrates and of glycosyl derivatives, glycol-polymers and glyco-conjugates. The book concludes with a chapter on latent functionality as a tactic toward formal protecting-group-free synthesis. A comprehensive account of established protecting-group-free (PGF) synthetic routes to molecules of medium to high complexity Benefits total synthesis, methodology development and drug synthesis researchers Supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and support the global need of practicing green chemistry Covers a topic that is gaining importance because it renders syntheses more economical Protecting-Group-Free Organic Synthesis: Improving Economy and Efficiency is an important book for academic researchers in synthetic organic chemistry, green chemistry, medicinal and pharmaceutical chemistry, biochemistry, and drug discovery.
Author: Stefan Berger Publisher: John Wiley & Sons ISBN: 9783527325160 Category : Science Languages : en Pages : 668
Book Description
Analytik von Naturstoffen, die jeder kennt: Die Autoren dieses Bandes beschränken sich nicht auf die nüchterne Abhandlung von Daten und Verfahren, sondern erzählen die wahrhaft inspirierenden Geschichten jedes ihrer Moleküle. Dabei ist der rein methodische Teil so ausführlich und exakt beschrieben, dass der Band hervorragend für Lehre und Studium geeignet ist. Übungsaufgaben mit Lösungen und das attraktive Layout machen das Buch zu einem Muss für jeden Organiker und Spektroskopiker und die, die es werden wollen.
Author: K. C. Nicolaou Publisher: Wiley-VCH ISBN: 9783527306848 Category : Science Languages : en Pages : 639
Book Description
Classics in Total Synthesis II is the long awaited sequel to Classics in Total Synthesis, a book that has made its mark as a superb tool for educating students and practitioners alike in the art of organic synthesis since its introduction in 1996. In this highly welcomed second volume, K.C. Nicolaou and Scott A. Snyder discuss in detail the most impressive accomplishments in natural product total synthesis during the 1990s and the first years of the 21st century. While all of the features that made the first volume of Classics so popular and unique as a teaching tool have been maintained, in this new treatise the authors seek to present the latest techniques and advance in organic synthesis as they beautifully describe the works of some of the most renowned synthetic organic chemists of our time. Key features include: Systematically develops domino reactions, cascade sequences, biomimetic strategies, and asymmetric catalysis through the chosen synthesis Discusses cutting edge synthetic technologies in terms of mechanism and scope Presents new reactions, such as olefin metathesis, in mini-review style Includes abundant references for further reading CD with useful teaching material for lecturers is included with hardback version (ISBN 3-527-30685-4) Graduate students, educators, and researchers in the fields of synthetic and medicinal chemistry will wish to have a copy of this book in their collection as an indispensable companion that both augments and supplements the original Classics in Total Synthesis. From the reviews: "... a volume, (...) which any chemist with an interest in synthetic organic chemistry will wish to acquire." –JACS (on the previous volume) "...this superb book (...) will be an essential purchase for many organic chemists." –Nature (on the previous volume) "...Classics II is undoubtedly an excellent bargain that is highly recommended to everybody interested in advanced organic chemistry. One of my co-workers confessed that Classics I was the book on his bedside table while he prepared his thesis defense. Isn't that the highest distinction for a monograph? I have every reason to believe that Classics II will equally stand the selection process by students (and probably their supervisors too)." –Angewandte Chemie, 2004 "Well, there is a new pleasant read for the advanced student and even the experienced. It is the second volume to the established Classics in Total Synthesis and it continues the series extremely well." –ChemBioChem, 2004 "...the real innovation of this volume is the inclusion of alternative pathways to the same target molecule by other researchers. This enables the reader to appreciate that there are also other solutions to certain structural problems than those of the original synthesis. ... Let us hope that K. C. Nicolaou and his associates will present us with these future achievements in the same clear, informative and innovative format they have with the previous two volumes." –Applied Organometallic Chemistry
Author: Vittorio Caprio Publisher: John Wiley & Sons ISBN: 1405190914 Category : Science Languages : en Pages : 409
Book Description
Asymmetric synthesis has become a major aspect of modern organic chemistry. The stereochemical properties of an organic compound are often essential to its bioactivity, and the need for stereochemically pure pharmaceutical products is a key example of the importance of stereochemical control in organic synthesis. However, achieving high levels of stereoselectivity in the synthesis of complex natural products represents a considerable intellectual and practical challenge for chemists. Written from a synthetic organic chemistry perspective, this text provides a practical overview of the field, illustrating a wide range of transformations that can be achieved. The book captures the latest advances in asymmetric catalysis with emphasis placed on non-enzymatic methods. Topics covered include: Reduction of alkenes, ketones and imines Nucleophilic addition to carbonyl compounds Catalytic carbon-carbon bond forming reactions Catalytic reactions involving metal carbenoids Conjugate addition reactions Catalysis in Asymmetric Synthesis bridges the gap between undergraduate and advanced level textbooks and provides a convenient point of entry to the primary literature for the experienced synthetic organic chemist.
Author: George S. Zweifel Publisher: John Wiley & Sons ISBN: 1119086760 Category : Science Languages : en Pages : 416
Book Description
This book bridges the gap between sophomore and advanced / graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment. • Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation • Uses a concise and easy-to-read style, with many illustrated examples • Updates material, examples, and references from the first edition • Adds coverage of organocatalysts and organometallic reagents
Author: Florencio Zaragoza Dörwald Publisher: John Wiley & Sons ISBN: 3527604987 Category : Science Languages : en Pages : 389
Book Description
Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure-reactivity relationship of organic compounds. This textbook highlights the competing processes and limitations of the most important reactions used in organic synthesis. By allowing chemists to quickly recognize potential problems this book will help to improve their efficiency and success-rate. A must for every graduate student but also for every chemist in industry and academia. Contents: 1 Organic Synthesis: General Remarks 2 Stereoelectronic Effects and Reactivity 3 The Stability of Organic Compounds 4 Aliphatic Nucleophilic Substitutions: Problematic Electrophiles 5 The Alkylation of Carbanions 6 The Alkylation of Heteroatoms 7 The Acylation of Heteroatoms 8 Palladium-Catalyzed C-C Bond Formation 9 Cyclizations 10 Monofunctionalization of Symmetric Difunctional Substrates
Author: Kakuzo Okakura Publisher: ReadHowYouWant.com ISBN: 1425000533 Category : Cooking Languages : en Pages : 110
Book Description
The Book of Tea is a brief but classic essay on tea drinking, its history, restorative powers, and rich connection to Japanese culture. Okakura felt that "Teaism" was at the very center of Japanese life and helped shape everything from art, aesthetics, and an appreciation for the ephemeral to architecture, design, gardens, and painting. In tea could be found one source of what Okakura felt was Japan's and, by extension, Asia's unique power to influence the world. Containing both a history of tea in Japan and lucid, wide-ranging comments on the schools of tea, Zen, Taoism, flower arranging, and the tea ceremony and its tea-masters, this book is deservedly a timeless classic and will be of interest to anyone interested in the Japanese arts and ways. Book jacket.
Author: K. C. Nicolaou
Author: K. C. Nicolaou
Author: K. C. Nicolaou
Author: K. C. Nicolaou
Author: Rodney A. Fernandes
Author: Stefan Berger
Author: K. C. Nicolaou
Author: Vittorio Caprio
Author: George S. Zweifel
Author: Florencio Zaragoza Dörwald
Author: Kakuzo Okakura