Regulation of Tissue Oxygenation, Second Edition PDF Download

Author: Roland N. Pittman
Publisher: Biota Publishing
ISBN: 1615047212
Category : Medical
Languages : en
Pages : 117

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Book Description
This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

Author: Marilyn J. Cipolla
Publisher: Biota Publishing
ISBN: 1615047239
Category : Medical
Languages : en
Pages : 82

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Book Description
This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Author: Michitoshi Inoue
Publisher: Springer Science & Business Media
ISBN: 4431683674
Category : Medical
Languages : en
Pages : 330

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Book Description
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

Author: Yuping Wang
Publisher: Biota Publishing
ISBN: 1615047514
Category : Medical
Languages : en
Pages : 126

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Book Description
The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.

Author: Robert E. Mehler
Publisher: John Wiley & Sons
ISBN: 1118951107
Category : Medical
Languages : en
Pages : 96

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Book Description
This book includes 10 lectures in a light, entertaining style, witheach "lecture" building on the previous one - making it easy forthe reader to comprehend the vastly complicated functions of thecirculatory system. The length of the text has intentionally been kept short; it isneither exhaustively complete nor over-simplified. It is enrichedby details about basic biologic mechanisms and clever ways naturehas solved a problem or achieved a result.

Author: Marie-Stéphanie Delamaire
Publisher: Open Book Publishers
ISBN: 1800641494
Category : Law
Languages : en
Pages : 334

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Book Description
The nineteenth century witnessed a series of revolutions in the production and circulation of images. From lithographs and engraved reproductions of paintings to daguerreotypes, stereoscopic views, and mass-produced sculptures, works of visual art became available in a wider range of media than ever before. But the circulation and reproduction of artworks also raised new questions about the legal rights of painters, sculptors, engravers, photographers, architects, collectors, publishers, and subjects of representation (such as sitters in paintings or photographs). Copyright and patent laws tussled with informal cultural norms and business strategies as individuals and groups attempted to exert some degree of control over these visual creations. With contributions by art historians, legal scholars, historians of publishing, and specialists of painting, photography, sculpture, and graphic arts, this rich collection of essays explores the relationship between intellectual property laws and the cultural, economic, and technological factors that transformed the pictorial landscape during the nineteenth century. This book will be valuable reading for historians of art and visual culture; legal scholars who work on the history of copyright and patent law; and literary scholars and historians who work in the field of book history. It will also resonate with anyone interested in current debates about the circulation and control of images in our digital age.

Author: Bengt Saltin
Publisher: Human Kinetics
ISBN: 0880116323
Category : Blood
Languages : en
Pages : 368

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Book Description
Explores the functioning cardiovascular system from an integrative viewpoint. Includes both historical developments and recent findings on the diverse aspects of cardiovascular function. Provides a conceptual framework for understanding cardiovascular function in health, as well as analysis of altered cardiovascular control during illness or under various physical and environmental conditions. Topics are presented from a basic science perspective with relevant implactions for clinical and applied settings offered.

Author: Maxime Cannesson
Publisher: Cambridge University Press
ISBN: 1316061442
Category : Medical
Languages : en
Pages : 301

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Book Description
This unique book provides clinicians and administrators with a comprehensive understanding of perioperative hemodynamic monitoring and goal directed therapy, emphasizing practical guidance for implementation at the bedside. Successful hemodynamic monitoring and goal directed therapy require a wide range of skills. This book will enable readers to: • Detail the rationale for using perioperative hemodynamic monitoring systems and for applying goal directed therapy protocols at the bedside • Understand the physiological concepts underlying perioperative goal directed therapy for hemodynamic management • Evaluate hemodynamic monitoring systems in clinical practice • Learn about new techniques for achieving goal directed therapy • Apply goal directed therapy protocols in the perioperative environment (including emergency departments, operating rooms and intensive care units) • Demonstrate clinical utility of GDT and hemodynamic optimization using case presentations. Illustrated with diagrams and case examples, this is an important resource for anesthesiologists, emergency physicians, intensivists and pneumonologists as well as nurses and administrative officers.

Author: William Harvey
Publisher: Cosimo, Inc.
ISBN: 1596052295
Category : Medical
Languages : en
Pages : 268

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Book Description
If the pulsations of the arteries fan and refrigerate the several parts of the body as the lungs do the heart, how comes it, as is commonly said, that the arteries carry the vital blood into the different parts, abundantly charged with vital spirits, which cherish the heat of these parts, sustain them when asleep, and recruit them when exhausted? and how should it happen that, if you tie the arteries, immediately the parts not only become torpid, and frigid, and look pale, but at length cease even to be nourished?-from the IntroductionThis seminal work of medical literature, first published in 1628, spells out in clear, lucid language how the human heart pumps blood around the body via its own exclusive circulatory route. What seems like an obvious concept to us today was in fact quite revolutionary at the time: Harvey's defiance of the medical "common knowledge" of his time laid the groundwork for all modern investigations of the circulatory system, and may be the most momentous discovery of 17th-century medicine.This important volume also includes a series of letters from Harvey to his medical colleagues in which he defends his then-astonishing theories, plus Harvey's "The Anatomy of Thomas Parr," a fascinating 1635 report on the dissection of the corpse of "a poor farmer of extremely advanced age."OF INTEREST TO: readers of scientific history, medical studentsBritish naturalist, anatomist, and doctor WILLIAM HARVEY (1578-1657) was educated at Cambridge, Canterbury, and Padua, and became a Fellow of the Royal College of Physicians in 1607. He served as court physician to both King James I and King Charles I.

Author: Colin J. Schwartz
Publisher: Springer Science & Business Media
ISBN: 1461579244
Category : Nature
Languages : en
Pages : 831

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Book Description
In order to produce a superior scholarly treatise in bio medical science, three important conditions need to be met. First, the subject needs to be of recognized importance and preferably one in which a sizeable volume of new knowledge has been added recently. Second, it needs to be quite evident that the field involved re quires much more up-to-date coverage than it has received and third, the choice of the editors and in turn the authors needs to be recognized as outstanding. This major treatise fills these criteria in an admirable way. There are few who would deny the importance of knowledge concerning the circulatory system. This all pervasive system is the route by which virtually all of the cells and tissues of the body receive their nutrition and it is the major route by which metabolic waste products are carried away. Furthermore, the diseases that involve the circulatory system are, by far, the underlying causes of death and morbidity in the largest number of Americans, Western Europeans and several other populations of industrialized nations. Not only is atherosclerosis-induced-ischemic disease of the heart, brain and extremities widespread in these populations but venous occlusive disease also takes a great toll from phlebothrombosis, pulmonary embolism, etc.