Molecular Biology of the Cell PDF Download

Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0

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Author: Gerald R. Reeck
Publisher: Springer Science & Business Media
ISBN: 1468476157
Category : Science
Languages : en
Pages : 359

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This book stems from an Advanced Study Institute on Chromo somal Proteins and Gene Expression that was held in Sitges, Spain, on September 17-26, 1984. It would be misleading to call this volume a conference proceedings, however. The ASI was not a conference, but a course with diverse activities, only one of which was a set of major presentations by the lecturers. Indeed, the concept of lecturer was intentionally obscured as we all learned from each other through shorter presentations by other participants and through seminars, poster sessions, and small group discussions. Furthermore, many participants found that exchanging ideas outside organized sessions was among the most rewarding aspects of the course. Some even claimed to have profitably probed the intricacies of nucleosome structure and transcriptional regulation while basking in the sun on the beachl Obviously, it is difficult to catch the flavor of such varied proceedings in a book. (I cannot confirm the incident on the beach, never having found time to set foot there. Such is the fate of the director of a meeting. ) The ASI was judged a success -- and enthusiastically so - by most participants. Not only did we deepen our understanding of our scientific field, we made new friends and learned about scientific and nonscientific aspects of life in other countries and about issues that transcend international boundaries in our complex world. We hope that this volume will be as successful as the course was.

Author: Proceedings of the National Academy of Sciences
Publisher: National Academies Press
ISBN: 0309084458
Category : Science
Languages : en
Pages : 442

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Over the past half-century, the central dogma, in which DNA makes RNA makes protein, has dominated thinking in biology, with continuing refinements in understanding of DNA inheritance, gene expression, and macromolecular interactions. However, we have also witnessed the elucidation of epigenetic phenomena that violate conventional notions of inheritance. Protein-only inheritance involves the transmission of phenotypes by self-perpetuating changes in protein conformation. Proteins that constitute chromatin can also transmit heritable information, for example, via posttranslational modifications of histones. Both the transmission of phenotypes via the formation of protein conformations and the inheritance of chromatin states involve self-perpetuating assemblies of proteins, and there is evidence for some common structural features and conceptual frameworks between them. To foster interactions between researchers in these two fields, the National Academy of Sciences convened an Arthur M.Sackler Colloquium entitled "Self-Perpetuating Structural States in Biology, Disease, and Genetics" in Washington, DC, on March 22-24, 2002. Participants described new phenomenology and provided insights into fundamental mechanisms of protein and chromatin inheritance. Perhaps most surprising to attendees was emerging evidence that these unconventional modes of inheritance may be common.

Author: Vincenzo E. A. Russo
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 716

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Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

Author: Ann Arvin
Publisher: Cambridge University Press
ISBN: 1139461648
Category : Medical
Languages : en
Pages : 1325

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This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Author: Gary Stein
Publisher: Elsevier
ISBN: 0323155987
Category : Science
Languages : en
Pages : 320

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Chromosomal Proteins and Their Role in the Regulation of Gene Expression examines how chromosomal proteins take part in the regulation of gene expression. This book also looks at the variety of approaches that are used in studying the structural and functional properties of chromosomal proteins, particularly as they relate to the control of transcription. This text is organized into 15 chapters and begins by analyzing the regulation of histone gene expression during the cell cycle and the role of non-histone chromosomal proteins in such regulation. The following chapters focus on the in vitro transcription of the globin gene in mouse fetal liver chromatin; the involvement of non-histone proteins in both positive and negative controls of gene activity; and the role of phosphorylated proteins as regulators of gene activity. The discussion then shifts to the phosphorylation state of non-histone proteins and its correlation with gene transcription; changes in nuclear proteins during embryonic development and cellular differentiation; and the manner by which histones are deposited onto replicating chromosomes. This book also explains the histone methylation, specific phosphorylation sites in lysine rich (H1) histone, and the separation and characterization of nuclear non-histone proteins by means of DNA columns. This book is of interest to advanced undergraduate students, as well as to graduate students and researchers in genetics, cell biology, molecular biology, biochemistry, and microbiology.

Author: Altuna Akalin
Publisher: CRC Press
ISBN: 1498781861
Category : Mathematics
Languages : en
Pages : 463

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Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.

Author: Renato Paro
Publisher: Springer Nature
ISBN: 3030686701
Category : Science
Languages : en
Pages : 215

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This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

Author: Julianne Zedalis
Publisher:
ISBN: 9781947172401
Category : Biology
Languages : en
Pages : 1923

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Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.

Author: Rajesh K. Gaur
Publisher: CRC Press
ISBN: 1420008706
Category : Science
Languages : en
Pages : 440

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New Findings Revolutionize Concepts of Gene FunctionEndogenous small RNAs have been found in various organisms, including humans, mice, flies, worms, fungi, and bacteria. Furthermore, it's been shown that microRNAs acting as cellular rheostats have the ability to modulate gene expression. In higher eukaryotes, microRNAs may regulate as much as 50 p